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Microscopy: The Global Market

  • August 2015
  • -
  • BCC Research
  • -
  • 132 pages

Use this report to:
- Identify the segments of the microscopy market with the greatest commercial potential in the near- to mid-term (2015 to 2020).
- Learn about recent developments in microscopy technologies and applications.
- Receive information about the future size and structure of the market for various types of microscopes and microscope accessories.
- Gain insight through comprehensive company profiles of major players in the market.

Highlights
- The global market for microscopes, accessories and supplies reached $4.3 billion in 2014. This market is expected to grow at a compound annual growth rate (CAGR) of 6.5% from $4.6 billion in 2015 to $6.3 billion in 2020.
- Microscopes as a segment will grow from $4.0 billion in 2015 to nearly $5.6 billion by 2020 at a 6.7% CAGR for the period 2015-2020.
- Accessories and supplies as a segment will grow from $595.5 million in 2015 to $752.8 million by 2020, increasing at a CAGR of 4.8% from 2015 through 2020.

Introduction & Scope

INTRODUCTION

STUDY BACKGROUND
The field of microscopy has undergone an enormous evolution since the earliest optical microscopes were developed in the 1600s. The optical microscope has been refined continuously since its introduction, resulting in today’s superb scientific instruments. However, the optical microscope is ultimately limited in the minimum size and nature of the features that it can resolve by manufacturability constraints and, ultimately, the
physics of light itself. New microscopy technologies have been developed to overcome these limitations, such as electron, scanning probe and focused ion beam microscopy. The field of microscopy continues to evolve rapidly as new requirements and imaging technologies are developed. While optical microscopes once accounted for the bulk of all microscopes sold around the world today, they are in the minority today.
While microscopes today are a multi-billion-dollar industry, their true importance lies in the activities they make possible, such as life sciences research, microelectronics and advanced-materials science. Microscopy is particularly important to the expanding field of nanotechnology.

STUDY GOALS AND OBJECTIVES
This report is an updated version of an earlier BCC Research study published in 2013. The goal of this study is to provide the reader with an understanding of recent developments in microscopy technologies and applications and their impact on the future size and structure of the market for various types of microscopes and microscope accessories. Specific study objectives include identifying segments of the microscopy market with the greatest commercial potential in the near- to mid-term (2015 to 2020), identifying and, where possible, quantifying the key demand drivers, projecting future demand for different types of microscopes, and evaluating the technical and other challenges that must be overcome for the market to realize its full potential.

INTENDED AUDIENCE
The report is intended especially for manufacturers and vendors of microscopes and related accessories. Other readers who should find it particularly useful include entrepreneurs, investors, venture capitalists and other readers with a need to know where the microscopy market is headed over the next five years. The report should also be of interest to end users such as nanotechnology companies, whose technology road maps may make critical assumptions about the availability and performance of different materials characterization technologies, including microscopes. Other potential readers include members of technical and professional organizations such as ASM International and the American Society for Nondestructive Testing.

SCOPE AND FORMAT
The report addresses the global market for microscopes and microscope accessories over the period from 2014 through 2020, including:
- Optical (light) microscopes.
- Electron microscopes.
- Scanning probe microscopes.
- Other types of microscope (e.g., focused ion beam, confocal).
- Microscope accessories.
The report includes the following major elements:
- Executive summary.
- Definitions.
- Brief history of microscopy.
- Microscope technologies.
- Patent analysis.
- Major end uses and applications.
- Global market trends by type of instrument, end-user segment and geographical region.
- Technology trends, limits and challenges.
- Industry structure (e.g., firm size and financial performance, ownership, market shares).

METHODOLOGY AND INFORMATION SOURCES
The findings and conclusions of this report are based on information gathered from industry sources, including microscope manufacturers and users. Interview data were combined with information gathered through an extensive review of secondary sources, such as trade publications, trade associations, company literature and online databases, to produce the projections contained in this report. The base year for analysis and projection is 2014. With 2014 as a baseline, market projections were developed for 2015 to 2020. These projections are based on a combination of a consensus among the primary contacts combined with our
understanding of the key market drivers and their impact from a historical and an analytical perspective. The analytical methodologies used to generate the market estimates are described in detail in the section on Detailed Market Projections.

Table Of Contents

Microscopy: The Global Market
TABLE OF CONTENTS
CHAPTER 1 INTRODUCTION 2
STUDY BACKGROUND 2
STUDY GOALS AND OBJECTIVES 2
INTENDED AUDIENCE 2
SCOPE AND FORMAT 3
METHODOLOGY AND INFORMATION SOURCES 3
ANALYST'S CREDENTIALS 3
RELATED BCC RESEARCH REPORTS 4
BCC RESEARCH WEBSITE 4
DISCLAIMER 4
CHAPTER 2 SUMMARY 6
SUMMARY TABLE GLOBAL MARKET FOR MICROSCOPES, ACCESSORIES AND
SUPPLIES, THROUGH 2020 ($ MILLIONS) 6
SUMMARY FIGURE GLOBAL MARKET FOR MICROSCOPES, ACCESSORIES AND
SUPPLIES, 2014-2020 ($ MILLIONS) 6
CHAPTER 3 MICROSCOPY OVERVIEW 9
GENERAL DESCRIPTION 9
DEFINITIONS 9
Charged Particle 9
Compound Microscope 9
Confocal Microscope 9
Depth of Field 9
Dispersion 9
Eyepiece 10
Inverted Microscope 10
Immersion Media 10
Lens 10
FIGURE 1 MAGNIFYING LENS PRINCIPLES 10
Magnification 11
Nanoscale 11
Near-Field 11
Numerical Aperture (NA) 11
Objective 11
Phase Shift 12
FIGURE 2 LIGHT WAVE PHASES 12
Polarization 13
FIGURE 3 POLARIZATION 13
Reflected Light Microscopes 13
Reflecting Microscopes 13
Refraction 14
FIGURE 4 REFRACTION 14
Resolution 15
Scanning Probe 15
Superconducting Quantum Interference Device (SQUID) 15
Stereoscopic 15
Tunneling Current 16
Wavelength 16
FIGURE 5 LIGHT WAVE 16
FIGURE 6 WAVELENGTHS USED IN OPTICAL MICROSCOPY (NM) 16
BRIEF HISTORY OF MICROSCOPY 17
TYPES OF MICROSCOPES 19
OPTICAL MICROSCOPES 19
Description and Applications 19
TABLE 1 TYPES AND MAIN APPLICATIONS OF OPTICAL MICROSCOPES 19
Upright (Compound) Microscopes 20
Binocular Stereomicroscopes 20
Polarizing Microscopes 20
Metallographic Microscopes 21
Reflecting Microscopes 21
FIGURE 7 REFLECTING MICROSCOPE 21
Phase Contrast Microscopes 22
FIGURE 8 BASIC PRINCIPLE OF A PHASE CONTRAST MICROSCOPE 23
Fluorescence Microscope 23
FIGURE 9 FLUORESCENCE MICROSCOPY PRINCIPLES 24
FIGURE 10 FLUORESCENCE MICROSCOPE LAYOUT 24
Confocal Microscopes 25
FIGURE 11 PRINCIPLES OF CONFOCAL MICROSCOPY 26
Scanning Near-Field Optical Microscopes (SNOMs) 28
FIGURE 12 SCANNING NEAR-FIELD OPTICAL MICROSCOPE PRINCIPLES 29
Inverted Microscopes 30
Other Types of Optical Microscopes 30
Advanced Confocal Microscopy 30
Phase-Sensitive Scatter-Field Optical Imaging 31
Stochastic Optical Reconstruction Microscopy (STORM) 31
Stimulated Emission Depletion Microscopy (STED) 31
Structured Illumination Microscopy (SIM) 32
Second Harmonic Generation (SHG) Microscopy 32
Super-Resolution Fluorescence Microscopy 32
Coherent Anti-Stokes Raman Scattering (CARS) Microscopy 32
Simultaneous Light Scattering Microscopy (LSM) 33
4Pi Microscopy 33
Microsphere Nanoscope 33
Metamaterial-Lens Microscopes 33
Single Plane Illumination Microscope 34
Patent Analysis 34
Technologies 34
TABLE 2 OPTICAL MICROSCOPY U.S. PATENTS AS OF JUNE 15, 2015 (NUMBER OF
PATENTS BY TYPE OF TECHNOLOGY) 35
FIGURE 13 OPTICAL MICROSCOPY U.S. PATENTS BY TYPE OF TECHNOLOGY, AS OF
JUNE 15, 2015 (PERCENT OF TOTAL PATENTS) 35
Trends Over Time 36
FIGURE 14 OPTICAL MICROSCOPY U.S. PATENTS ISSUED ANNUALLY BY TYPE OF
TECHNOLOGY, 2005-2015 (NUMBER OF PATENTS) 36
TABLE 3 OPTICAL MICROSCOPY U.S. PATENTS ISSUED ANNUALLY BY TYPE OF
TECHNOLOGY, 2005-2015 (NUMBER OF PATENTS) 37
Patent Holders 37
FIGURE 15 MAJOR OPTICAL MICROSCOPY U.S. PATENT HOLDERS, 2015 (%) 37
TABLE 4 MAJOR OPTICAL MICROSCOPY U.S. PATENT HOLDERS, 2015 (NUMBER/%) 38
FIGURE 16 MAJOR OPTICAL MICROSCOPY U.S. PATENT HOLDERS BY TECHNOLOGY
TYPE, 2015 (PERCENTAGES OF TOTAL PATENTS) 38
TABLE 5 OPTICAL MICROSCOPY U.S. PATENT HOLDERS BY TECHNOLOGY TYPE,
2015 (NUMBER OF PATENTS) 39
Manufacturers 39
TABLE 6 OPTICAL MICROSCOPE MANUFACTURERS, 2015 40
CHARGED PARTICLE MICROSCOPES 41
Description and Applications 41
TABLE 7 TYPES AND PRIMARY APPLICATIONS OF CHARGED PARTICLE
MICROSCOPES 41
Transmission Electron Microscopes 42
FIGURE 17 TRANSMISSION ELECTRON MICROSCOPE 43
Scanning Electron Microscopes (SEMs) 44
FIGURE 18 SCANNING ELECTRON MICROSCOPE 45
FIGURE 19 SCANNING ELECTRON MICROSCOPE - SAMPLE INTERACTION 46
Environmental Scanning Electron Microscopes (ESEMs) 46
Field Emission Scanning Electron Microscopes (FESEMs) 47
Field Ion Microscopes (FIMs) 48
Other Types of Electron Microscopes 48
Electron Probe Microanalyzers (EPMAs) 48
Scanning Transmission Electron Microscopes (STEMs) 48
High-Voltage Electron Microscopes 48
Focused Ion Beam (FIB) Microscopes 49
Reflection Electron Microscopes (REMs) 50
Low-Energy Electron Microscopy (LEEM) 50
Photoelectron Emission Microscopes (PEEMs) 51
Patent Analysis 51
Technologies 51
FIGURE 20 CHARGED PARTICLE MICROSCOPY U.S. PATENTS BY TYPE OF
TECHNOLOGY, THROUGH JUNE 15, 2015 (PERCENT OF U.S. PATENTS ISSUED) 51
TABLE 8 CHARGED PARTICLE MICROSCOPY U.S. PATENTS, THROUGH JUNE 15,
2015 (NUMBER/%) 52
FIGURE 21 CHARGED PARTICLE MICROSCOPY U.S. PATENTS ISSUED ANNUALLY BY
TYPE OF TECHNOLOGY, 2005-2015 (NUMBER OF PATENTS) 53
TABLE 9 CHARGED PARTICLE MICROSCOPY U.S. PATENTS ISSUED ANNUALLY BY
TYPE OF TECHNOLOGY, THROUGH JUNE 15, 2015 (NUMBER OF PATENTS) 53
Patent Holders 54
FIGURE 22 CHARGED PARTICLE MICROSCOPE U.S. PATENT HOLDERS, THROUGH
JUNE 15, 2015 (% OF TOTAL PATENTS ISSUED) 54
TABLE 10 CHARGED PARTICLE MICROSCOPY U.S. PATENT HOLDERS, THROUGH
JUNE 15, 2015 (NUMBER OF PATENTS ISSUED) 54
FIGURE 23 MAJOR CHARGED PARTICLE MICROSCOPY U.S. PATENT HOLDERS BY
TECHNOLOGY TYPE, 2015 (PERCENT OF TOTAL PATENTS) 55
TABLE 11 MAJOR CHARGED PARTICLE MICROSCOPY U.S. PATENT HOLDERS, BY
TECHNOLOGY TYPE, 2015 (NUMBER OF PATENTS) 55
Manufacturers 56
TABLE 12 CHARGED PARTICLE MICROSCOPE MANUFACTURERS, 2015 56
SCANNING-PROBE MICROSCOPES 57
Description and Applications 57
FIGURE 24 SCANNING PROBE MICROSCOPE 57
TABLE 13 TYPES AND PRIMARY APPLICATIONS OF SCANNING PROBE MICROSCOPES 58
Scanning Tunneling Microscopes (STMs) 58
Atomic Force Microscopes (AFMs) 59
FIGURE 25 ATOMIC FORCE MICROSCOPE PROBE 59
Other Types of Scanning Probe Microscopes 61
Magnetic Force Microscopes (MFMs) 61
Electric Force Microscopes (EFMs) 61
Scanning Thermal Microscopy (SThM) 62
Patent Analysis 62
Technologies 63
FIGURE 26 SCANNING PROBE MICROSCOPY U.S. PATENTS BY TYPE OF
TECHNOLOGY, AS OF JUNE 15, 2015 (PERCENT OF TOTAL PATENTS) 63
TABLE 14 SCANNING PROBE MICROSCOPY U.S. PATENTS, AS OF JUNE 15, 2015
(NUMBER/%) 63
Trends Over Time 63
FIGURE 27 SCANNING PROBE MICROSCOPY U.S. PATENTS ISSUED ANNUALLY BY
TYPE OF TECHNOLOGY, 2005-2015 (NUMBER OF PATENTS ISSUED ANNUALLY) 64
TABLE 15 SCANNING PROBE MICROSCOPY U.S. PATENTS ISSUED ANNUALLY BY
TYPE OF TECHNOLOGY, 2005-2015 (NUMBER OF PATENTS) 64
Patent Holders 64
FIGURE 28 SCANNING PROBE MICROSCOPE U.S. PATENT HOLDERS, THROUGH
JUNE 15, 2015 (PERCENT OF TOTAL U.S. PATENTS ISSUED) 65
TABLE 16 SCANNING PROBE MICROSCOPY U.S. PATENT HOLDERS, THROUGH JUNE
15, 2015 (NUMBER/%) 65
FIGURE 29 MAJOR SPM U.S. PATENT HOLDERS BY TECHNOLOGY TYPE, THROUGH
JUNE 15, 2015 (PERCENT OF TOTAL PATENTS) 65
TABLE 17 SCANNING PROBE MICROSCOPY U.S. PATENT HOLDERS BY TECHNOLOGY
TYPE, THROUGH JUNE 15, 2015 (NUMBER OF PATENTS) 66
Manufacturers 67
TABLE 18 SCANNING PROBE MICROSCOPE MANUFACTURERS, 2015 67
ACCESSORIES AND SUPPLIES 68
Description and Applications 68
TABLE 19 MICROSCOPE ACCESSORIES AND THEIR MAIN FUNCTIONS 68
Photomicroscopy Equipment 68
Illumination Systems 69
Microscope Stages and Accessories 69
Eyepieces 70
Objectives 70
Scanning Probes 70
Consumables 71
Patent Analysis 71
Accessory Types 71
FIGURE 30 MICROSCOPE ACCESSORY U.S. PATENTS BY ACCESSORY TYPE, AS OF
JUNE 15, 2015 (PERCENT OF TOTAL PATENTS ISSUED) 72
TABLE 20 MICROSCOPE ACCESSORY U.S. PATENTS, AS OF JUNE 15, 2015
(NUMBER/%) 72
Patent Holders 72
FIGURE 31 MICROSCOPE ACCESSORY U.S. PATENT HOLDERS, THROUGH JUNE 15,
2015 (PERCENT OF PATENTS ISSUED) 73
TABLE 21 MICROSCOPE ACCESSORY U.S. PATENT HOLDERS AND APPLICANTS,
THROUGH JUNE 15, 2015 (%) 73
Manufacturers 73
TABLE 22 MICROSCOPE ACCESSORY MANUFACTURERS, 2015 74
END USERS 74
TABLE 23 MICROSCOPE END-USER INDUSTRIES 74
SEMICONDUCTORS 75
Optical Microscopes 75
Charged Particle Microscopes 76
Scanning Probe Microscopes 76
PHOTOVOLTAICS (PV) 77
LIFE SCIENCES 77
TABLE 24 GLOBAL LIFE SCIENCES SALES, 2014 ($ BILLIONS) 77
Optical Microscopes 78
Charged Particle Microscopes 78
MATERIALS SCIENCE 79
FIGURE 32 MATERIALS SCIENCE INSTRUMENTS MAJOR MARKET SEGMENTS, 2014
(PERCENT OF TOTAL SALES) 79
Optical Microscopes 80
Charged Particle Microscopes 81
Scanning Probe Microscopes 81
NANOTECHNOLOGY 82
Charged Particle Microscopes 82
Scanning Probe Microscopes 82
OTHER END USERS 83
Education 83
Optical Microscopes 83
Other Types of Microscopes 83
Environmental Science 83
Optical Microscopes 83
Charged Particle Microscopes 84
Forensics 84
Optical Microscopes 84
Charged Particle Microscopes 84
Food Processing 85
Optical Microscopes 85
Charged Particle Microscopes 85
CHAPTER 4 GLOBAL MARKET FOR MICROSCOPES AND ACCESSORIES 87
OVERALL MARKET SIZE AND SEGMENTATION 87
FIGURE 33 GLOBAL SALES OF MICROSCOPES AND ACCESSORIES/SUPPLIES,
2014-2020 ($ MILLIONS) 87
DETAILED MARKET ANALYSIS AND PROJECTIONS 87
MARKET BY PRODUCT TYPE 87
TABLE 25 PROJECTED GLOBAL MICROSCOPE SALES BY PRODUCT TYPE, THROUGH
2020 ($ MILLIONS) 88
FIGURE 34 MICROSCOPY MAJOR MARKET SEGMENTS, 2014 VERSUS 2020 (%) 88
Optical Microscopes 89
Optical Microscope Market Size and Segmentation 89
FIGURE 35 OPTICAL MICROSCOPE MARKET SEGMENTATION, 2014 (% OF TOTAL
OPTICAL MICROSCOPE SALES) 90
TABLE 26 OPTICAL MICROSCOPE SALES, 2014 ($ MILLIONS/%) 90
Market Drivers 90
Spending on Educational Equipment 91
FIGURE 36 U.S. EDUCATIONAL EXPENDITURES, 2002-2020 ($ BILLIONS) 91
TABLE 27 U.S. EDUCATIONAL EXPENDITURES, THROUGH 2020 ($ BILLIONS) 92
Trends in Infrared Spectroscopy 92
TABLE 28 GLOBAL MOLECULAR SPECTROMETRY SALES, THROUGH 2020 ($
BILLIONS) 92
Life Sciences RandD and Healthcare Spending 93
FIGURE 37 LIFE SCIENCES R andD SPENDING, 2014-2020 ($ BILLIONS) 93
TABLE 29 LIFE SCIENCES R andD SPENDING, THROUGH 2020 ($ BILLIONS) 93
Materials Science Instrument Spending 94
FIGURE 38 MATERIALS CHARACTERIZATION INSTRUMENT SALES, 2014-2020 ($
BILLIONS) 94
TABLE 30 GLOBAL SPENDING ON MATERIALS CHARACTERIZATION INSTRUMENTS,
THROUGH 2020 ($ BILLIONS) 94
Technology Shift Away From Compound Optical Microscopy 94
Future Market for Optical Microscopes 95
TABLE 31 PROJECTED SALES OF OPTICAL MICROSCOPES, THROUGH 2020 ($
MILLIONS) 95
TABLE 32 PROJECTED GROWTH RATE OF MARKET FOR STEREOSCOPIC
MICROSCOPES, THROUGH 2020 (PERCENT CAGR) 96
TABLE 33 PROJECTED GROWTH RATE OF MARKET FOR SCANNING NEAR-FIELD
OPTICAL MICROSCOPES, THROUGH 2020 (PERCENT CAGR) 96
FIGURE 39 OPTICAL MICROSCOPE MARKET SEGMENTATION, 2020 (%) 97
Charged Particle Microscopes 97
Charged Particle Microscope Market Size and Segmentation 97
FIGURE 40 CHARGED PARTICLE MICROSCOPE MARKET SEGMENTS, 2014 (%) 98
TABLE 34 CHARGED PARTICLE MICROSCOPE SALES, 2014 ($ MILLIONS/%) 98
Market Drivers 98
Semiconductor Industry Investment Trends 99
FIGURE 41 MARKETS FOR SCANNING ELECTRON MICROSCOPES, 2014 (PERCENT
OF TOTAL SEM SALES) 99
FIGURE 42 PROJECTED GROWTH IN SEMICONDUCTOR CAPITAL EQUIPMENT
SPENDING, 2014-2020 ($ BILLIONS) 100
TABLE 35 SEMICONDUCTOR INDUSTRY CAPITAL EQUIPMENT SPENDING
PROJECTIONS, THROUGH 2020 ($ BILLIONS) 100
Technology Shifts 100
FIGURE 43 CHARGED PARTICLE MICROSCOPE SALES GROWTH VERSUS GROWTH IN
MAJOR UNDERLYING MARKETS, 2003-2008 (CAGR%) 100
Future Market for Charged Particle Microscopes 102
TABLE 36 PROJECTED SALES OF CHARGED PARTICLE MICROSCOPES, THROUGH
2020 ($ MILLIONS) 102
TABLE 37 PROJECTED GROWTH RATE OF SEM SALES TO THE LIFE AND MATERIALS
SCIENCES, THROUGH 2020 ($ MILLIONS) 103
FIGURE 44 CHARGED PARTICLE MICROSCOPE MARKET SEGMENTS, 2020 (PERCENT
OF TOTAL SALES) 103
Scanning Probe Microscopes 104
Scanning Probe Microscope Market Size and Segmentation 104
FIGURE 45 SPM MARKET PRODUCT SEGMENTS, 2014 (%) 105
Market Drivers 105
Trends in Nanoscale Applications 105
Technology Shifts 106
Future Market for Scanning Probe Microscopes 106
TABLE 38 PROJECTED SALES OF SCANNING PROBE MICROSCOPES, THROUGH 2020
($ MILLIONS) 106
FIGURE 46 SCANNING PROBE MICROSCOPE MARKET SEGMENTS, 2020 (PERCENT
OF TOTAL SALES) 106
Accessories and Supplies 107
Market Size and Segmentation 107
FIGURE 47 MICROSCOPE ACCESSORIES AND SUPPLIES MARKET SEGMENTATION,
2014 (%) 108
TABLE 39 SALES OF MICROSCOPE ACCESSORIES AND CONSUMABLES, 2014 ($
MILLIONS/%) 108
Market Drivers 108
Number of Microscopes in Use Worldwide 108
FIGURE 48 TRENDS IN NUMBER OF MICROSCOPES IN USE WORLDWIDE, 2014-2020
(MILLION UNITS) 108
TABLE 40 NUMBER OF MICROSCOPES IN USE WORLDWIDE, THROUGH 2020
(MILLION UNITS) 109
Future Markets for Microscope Accessories and Supplies 110
TABLE 41 PROJECTED SALES OF MICROSCOPE ACCESSORIES AND SUPPLIES,
THROUGH 2020 ($ MILLIONS) 110
MARKETS BY END-USER SEGMENT 110
Optical Microscopes 110
FIGURE 49 OPTICAL MICROSCOPE MARKET SHARES BY END-USER SEGMENT, 2014
VERSUS 2020 (%) 110
TABLE 42 END-USER MARKETS FOR OPTICAL MICROSCOPES, THROUGH 2020 ($
MILLIONS) 112
Charged Particle Microscopes 112
FIGURE 50 CHARGED PARTICLE MICROSCOPE MARKET SHARES BY END-USER
SEGMENT, 2014 VERSUS 2020 (%) 112
TABLE 43 END-USER MARKETS FOR CHARGED PARTICLE MICROSCOPES, THROUGH
2020 ($ MILLIONS) 113
Scanning Probe Microscopes 113
All Types of Microscopes 113
FIGURE 51 MICROSCOPE MARKET SHARES BY END-USER SEGMENT, 2014 VERSUS
2020 (%) 113
TABLE 44 END-USER MARKETS FOR ALL TYPES OF MICROSCOPES, THROUGH 2020
($ MILLIONS) 115
GEOGRAPHICAL MARKETS 115
Optical Microscopes 115
FIGURE 52 OPTICAL MICROSCOPE GEOGRAPHICAL MARKET SHARES, 2014 VERSUS
2020 (%) 115
TABLE 45 GEOGRAPHICAL MARKETS FOR OPTICAL MICROSCOPES, THROUGH 2020
($ MILLIONS) 117
Charged Particle Microscopes 117
FIGURE 53 CHARGED PARTICLE MICROSCOPE GEOGRAPHICAL MARKET SHARES,
2014 VERSUS 2020 (%) 117
TABLE 46 GEOGRAPHICAL MARKETS FOR CHARGED PARTICLE MICROSCOPES,
THROUGH 2020 ($ MILLIONS) 119
Scanning Probe Microscopes 119
FIGURE 54 SCANNING PROBE MICROSCOPE GEOGRAPHICAL MARKET SHARES,
2014 VERSUS 2020 (%) 119
TABLE 47 GEOGRAPHICAL MARKETS FOR SCANNING PROBE MICROSCOPES,
THROUGH 2020 ($ MILLIONS) 120
All Types of Microscopes 120
FIGURE 55 MICROSCOPE MARKET SHARES BY END-USER SEGMENT, 2014 VERSUS
2020 (%) 121
TABLE 48 GEOGRAPHICAL MARKETS FOR ALL TYPES OF MICROSCOPES, THROUGH
2020 ($ MILLIONS) 121
CHAPTER 5 INDUSTRY STRUCTURE 124
MARKET SHARES 124
OPTICAL MICROSCOPES 124
FIGURE 56 OPTICAL MICROSCOPY MARKET SHARES, 2014 (%) 124
CHARGED PARTICLE MICROSCOPES 125
Electron Microscopes 125
FIGURE 57 ELECTRON MICROSCOPE MARKET SHARES, 2014 (%) 125
Focused Ion Beam Microscopes 125
FIGURE 58 FOCUSED ION BEAM MICROSCOPE MARKET SHARES, 2014 (%) 126
SCANNING PROBE MICROSCOPES 126
FIGURE 59 SCANNING PROBE MICROSCOPE MARKET SHARES, 2014 (%) 126
OWNERSHIP TRENDS 127
CHAPTER 6 COMPANY PROFILES 130
APPLIED MATERIALS, INC. 130
BRUKER AXS 130
BRUKER OPTICS INC. 130
BUEHLER INC. 130
CAMECA SA 131
DANISH MICRO ENGINEERING A/S 131
FEI COMPANY 131
GATAN, INC. 132
HITACHI HIGH TECHNOLOGIES CORP. 132
JASCO INTERNATIONAL CO. LTD. 132
JEOL LTD. 133
LEICA MICROSYSTEMS AG 133
MIS INC. 133
NANONICS IMAGING LTD. 134
NANOSURF AG 134
NIKON CORP. 134
NT-MDT CO. 135
OBDUCAT AB 135
OLYMPUS CORPORATION 135
PARK SYSTEMS CORP. 135
PERKIN ELMER, INC. 136
QUESTAR CORP. 136
SCHOTT NORTH AMERICA INC. 136
SCIENTA OMICRON GMBH 136
SHIMADZU CORP. 137
THERMO FISHER SCIENTIFIC INC. 137
WITEC WISSENSCHAFTLICHE INSTRUMENTE UND TECHNOLOGIE GMBH 137
ZEISS (CARL) NTS GMBH 137

LIST OF TABLES
SUMMARY TABLE GLOBAL MARKET FOR MICROSCOPES, ACCESSORIES AND
SUPPLIES, THROUGH 2020 ($ MILLIONS) 6
TABLE 1 TYPES AND MAIN APPLICATIONS OF OPTICAL MICROSCOPES 19
TABLE 2 OPTICAL MICROSCOPY U.S. PATENTS AS OF JUNE 15, 2015 (NUMBER OF
PATENTS BY TYPE OF TECHNOLOGY) 35
TABLE 3 OPTICAL MICROSCOPY U.S. PATENTS ISSUED ANNUALLY BY TYPE OF
TECHNOLOGY, 2005-2015 (NUMBER OF PATENTS) 37
TABLE 4 MAJOR OPTICAL MICROSCOPY U.S. PATENT HOLDERS, 2015 (NUMBER/%) 38
TABLE 5 OPTICAL MICROSCOPY U.S. PATENT HOLDERS BY TECHNOLOGY TYPE, 2015
(NUMBER OF PATENTS) 39
TABLE 6 OPTICAL MICROSCOPE MANUFACTURERS, 2015 40
TABLE 7 TYPES AND PRIMARY APPLICATIONS OF CHARGED PARTICLE MICROSCOPES 41
TABLE 8 CHARGED PARTICLE MICROSCOPY U.S. PATENTS, THROUGH JUNE 15, 2015
(NUMBER/%) 52
TABLE 9 CHARGED PARTICLE MICROSCOPY U.S. PATENTS ISSUED ANNUALLY BY
TYPE OF TECHNOLOGY, THROUGH JUNE 15, 2015 (NUMBER OF PATENTS) 53
TABLE 10 CHARGED PARTICLE MICROSCOPY U.S. PATENT HOLDERS, THROUGH JUNE
15, 2015 (NUMBER OF PATENTS ISSUED) 54
TABLE 11 MAJOR CHARGED PARTICLE MICROSCOPY U.S. PATENT HOLDERS, BY
TECHNOLOGY TYPE, 2015 (NUMBER OF PATENTS) 55
TABLE 12 CHARGED PARTICLE MICROSCOPE MANUFACTURERS, 2015 56
TABLE 13 TYPES AND PRIMARY APPLICATIONS OF SCANNING PROBE MICROSCOPES 58
TABLE 14 SCANNING PROBE MICROSCOPY U.S. PATENTS, AS OF JUNE 15, 2015
(NUMBER/%) 63
TABLE 15 SCANNING PROBE MICROSCOPY U.S. PATENTS ISSUED ANNUALLY BY TYPE
OF TECHNOLOGY, 2005-2015 (NUMBER OF PATENTS) 64
TABLE 16 SCANNING PROBE MICROSCOPY U.S. PATENT HOLDERS, THROUGH JUNE
15, 2015 (NUMBER/%) 65
TABLE 17 SCANNING PROBE MICROSCOPY U.S. PATENT HOLDERS BY TECHNOLOGY
TYPE, THROUGH JUNE 15, 2015 (NUMBER OF PATENTS) 66
TABLE 18 SCANNING PROBE MICROSCOPE MANUFACTURERS, 2015 67
TABLE 19 MICROSCOPE ACCESSORIES AND THEIR MAIN FUNCTIONS 68
TABLE 20 MICROSCOPE ACCESSORY U.S. PATENTS, AS OF JUNE 15, 2015
(NUMBER/%) 72
TABLE 21 MICROSCOPE ACCESSORY U.S. PATENT HOLDERS AND APPLICANTS,
THROUGH JUNE 15, 2015 (%) 73
TABLE 22 MICROSCOPE ACCESSORY MANUFACTURERS, 2015 74
TABLE 23 MICROSCOPE END-USER INDUSTRIES 74
TABLE 24 GLOBAL LIFE SCIENCES SALES, 2014 ($ BILLIONS) 77
TABLE 25 PROJECTED GLOBAL MICROSCOPE SALES BY PRODUCT TYPE, THROUGH
2020 ($ MILLIONS) 88
TABLE 26 OPTICAL MICROSCOPE SALES, 2014 ($ MILLIONS/%) 90
TABLE 27 U.S. EDUCATIONAL EXPENDITURES, THROUGH 2020 ($ BILLIONS) 92
TABLE 28 GLOBAL MOLECULAR SPECTROMETRY SALES, THROUGH 2020 ($ BILLIONS) 92
TABLE 29 LIFE SCIENCES R andD SPENDING, THROUGH 2020 ($ BILLIONS) 93
TABLE 30 GLOBAL SPENDING ON MATERIALS CHARACTERIZATION INSTRUMENTS,
THROUGH 2020 ($ BILLIONS) 94
TABLE 31 PROJECTED SALES OF OPTICAL MICROSCOPES, THROUGH 2020 ($
MILLIONS) 95
TABLE 32 PROJECTED GROWTH RATE OF MARKET FOR STEREOSCOPIC
MICROSCOPES, THROUGH 2020 (PERCENT CAGR) 96
TABLE 33 PROJECTED GROWTH RATE OF MARKET FOR SCANNING NEAR-FIELD
OPTICAL MICROSCOPES, THROUGH 2020 (PERCENT CAGR) 96
TABLE 34 CHARGED PARTICLE MICROSCOPE SALES, 2014 ($ MILLIONS/%) 98
TABLE 35 SEMICONDUCTOR INDUSTRY CAPITAL EQUIPMENT SPENDING
PROJECTIONS, THROUGH 2020 ($ BILLIONS) 100
TABLE 36 PROJECTED SALES OF CHARGED PARTICLE MICROSCOPES, THROUGH
2020 ($ MILLIONS) 102
TABLE 37 PROJECTED GROWTH RATE OF SEM SALES TO THE LIFE AND MATERIALS
SCIENCES, THROUGH 2020 ($ MILLIONS) 103
TABLE 38 PROJECTED SALES OF SCANNING PROBE MICROSCOPES, THROUGH 2020
($ MILLIONS) 106
TABLE 39 SALES OF MICROSCOPE ACCESSORIES AND CONSUMABLES, 2014 ($
MILLIONS/%) 108
TABLE 40 NUMBER OF MICROSCOPES IN USE WORLDWIDE, THROUGH 2020
(MILLION UNITS) 109
TABLE 41 PROJECTED SALES OF MICROSCOPE ACCESSORIES AND SUPPLIES,
THROUGH 2020 ($ MILLIONS) 110
TABLE 42 END-USER MARKETS FOR OPTICAL MICROSCOPES, THROUGH 2020 ($
MILLIONS) 112
TABLE 43 END-USER MARKETS FOR CHARGED PARTICLE MICROSCOPES, THROUGH
2020 ($ MILLIONS) 113
TABLE 44 END-USER MARKETS FOR ALL TYPES OF MICROSCOPES, THROUGH 2020
($ MILLIONS) 115
TABLE 45 GEOGRAPHICAL MARKETS FOR OPTICAL MICROSCOPES, THROUGH 2020
($ MILLIONS) 117
TABLE 46 GEOGRAPHICAL MARKETS FOR CHARGED PARTICLE MICROSCOPES,
THROUGH 2020 ($ MILLIONS) 119
TABLE 47 GEOGRAPHICAL MARKETS FOR SCANNING PROBE MICROSCOPES,
THROUGH 2020 ($ MILLIONS) 120
TABLE 48 GEOGRAPHICAL MARKETS FOR ALL TYPES OF MICROSCOPES, THROUGH
2020 ($ MILLIONS) 121

LIST OF FIGURES
SUMMARY FIGURE GLOBAL MARKET FOR MICROSCOPES, ACCESSORIES AND
SUPPLIES, 2014-2020 ($ MILLIONS) 6
FIGURE 1 MAGNIFYING LENS PRINCIPLES 10
FIGURE 2 LIGHT WAVE PHASES 12
FIGURE 3 POLARIZATION 13
FIGURE 4 REFRACTION 14
FIGURE 5 LIGHT WAVE 16
FIGURE 6 WAVELENGTHS USED IN OPTICAL MICROSCOPY (NM) 16
FIGURE 7 REFLECTING MICROSCOPE 21
FIGURE 8 BASIC PRINCIPLE OF A PHASE CONTRAST MICROSCOPE 23
FIGURE 9 FLUORESCENCE MICROSCOPY PRINCIPLES 24
FIGURE 10 FLUORESCENCE MICROSCOPE LAYOUT 24
FIGURE 11 PRINCIPLES OF CONFOCAL MICROSCOPY 26
FIGURE 12 SCANNING NEAR-FIELD OPTICAL MICROSCOPE PRINCIPLES 29
FIGURE 13 OPTICAL MICROSCOPY U.S. PATENTS BY TYPE OF TECHNOLOGY, AS OF
JUNE 15, 2015 (PERCENT OF TOTAL PATENTS) 35
FIGURE 14 OPTICAL MICROSCOPY U.S. PATENTS ISSUED ANNUALLY BY TYPE OF
TECHNOLOGY, 2005-2015 (NUMBER OF PATENTS) 36
FIGURE 15 MAJOR OPTICAL MICROSCOPY U.S. PATENT HOLDERS, 2015 (%) 37
FIGURE 16 MAJOR OPTICAL MICROSCOPY U.S. PATENT HOLDERS BY TECHNOLOGY
TYPE, 2015 (PERCENTAGES OF TOTAL PATENTS) 38
FIGURE 17 TRANSMISSION ELECTRON MICROSCOPE 43
FIGURE 18 SCANNING ELECTRON MICROSCOPE 45
FIGURE 19 SCANNING ELECTRON MICROSCOPE - SAMPLE INTERACTION 46
FIGURE 20 CHARGED PARTICLE MICROSCOPY U.S. PATENTS BY TYPE OF
TECHNOLOGY, THROUGH JUNE 15, 2015 (PERCENT OF U.S. PATENTS ISSUED) 51
FIGURE 21 CHARGED PARTICLE MICROSCOPY U.S. PATENTS ISSUED ANNUALLY BY
TYPE OF TECHNOLOGY, 2005-2015 (NUMBER OF PATENTS) 53
FIGURE 22 CHARGED PARTICLE MICROSCOPE U.S. PATENT HOLDERS, THROUGH
JUNE 15, 2015 (% OF TOTAL PATENTS ISSUED) 54
FIGURE 23 MAJOR CHARGED PARTICLE MICROSCOPY U.S. PATENT HOLDERS BY
TECHNOLOGY TYPE, 2015 (PERCENT OF TOTAL PATENTS) 55
FIGURE 24 SCANNING PROBE MICROSCOPE 57
FIGURE 25 ATOMIC FORCE MICROSCOPE PROBE 59
FIGURE 26 SCANNING PROBE MICROSCOPY U.S. PATENTS BY TYPE OF TECHNOLOGY,
AS OF JUNE 15, 2015 (PERCENT OF TOTAL PATENTS) 63
FIGURE 27 SCANNING PROBE MICROSCOPY U.S. PATENTS ISSUED ANNUALLY BY
TYPE OF TECHNOLOGY, 2005-2015 (NUMBER OF PATENTS ISSUED ANNUALLY) 64
FIGURE 28 SCANNING PROBE MICROSCOPE U.S. PATENT HOLDERS, THROUGH JUNE
15, 2015 (PERCENT OF TOTAL U.S. PATENTS ISSUED) 65
FIGURE 29 MAJOR SPM U.S. PATENT HOLDERS BY TECHNOLOGY TYPE, THROUGH
JUNE 15, 2015 (PERCENT OF TOTAL PATENTS) 65
FIGURE 30 MICROSCOPE ACCESSORY U.S. PATENTS BY ACCESSORY TYPE, AS OF
JUNE 15, 2015 (PERCENT OF TOTAL PATENTS ISSUED) 72
FIGURE 31 MICROSCOPE ACCESSORY U.S. PATENT HOLDERS, THROUGH JUNE 15,
2015 (PERCENT OF PATENTS ISSUED) 73
FIGURE 32 MATERIALS SCIENCE INSTRUMENTS MAJOR MARKET SEGMENTS, 2014
(PERCENT OF TOTAL SALES) 79
FIGURE 33 GLOBAL SALES OF MICROSCOPES AND ACCESSORIES/SUPPLIES,
2014-2020 ($ MILLIONS) 87
FIGURE 34 MICROSCOPY MAJOR MARKET SEGMENTS, 2014 VERSUS 2020 (%) 88
FIGURE 35 OPTICAL MICROSCOPE MARKET SEGMENTATION, 2014 (% OF TOTAL
OPTICAL MICROSCOPE SALES) 90
FIGURE 36 U.S. EDUCATIONAL EXPENDITURES, 2002-2020 ($ BILLIONS) 91
FIGURE 37 LIFE SCIENCES R andD SPENDING, 2014-2020 ($ BILLIONS) 93
FIGURE 38 MATERIALS CHARACTERIZATION INSTRUMENT SALES, 2014-2020 ($
BILLIONS) 94
FIGURE 39 OPTICAL MICROSCOPE MARKET SEGMENTATION, 2020 (%) 97
FIGURE 40 CHARGED PARTICLE MICROSCOPE MARKET SEGMENTS, 2014 (%) 98
FIGURE 41 MARKETS FOR SCANNING ELECTRON MICROSCOPES, 2014 (PERCENT OF
TOTAL SEM SALES) 99
FIGURE 42 PROJECTED GROWTH IN SEMICONDUCTOR CAPITAL EQUIPMENT
SPENDING, 2014-2020 ($ BILLIONS) 100
FIGURE 43 CHARGED PARTICLE MICROSCOPE SALES GROWTH VERSUS GROWTH IN
MAJOR UNDERLYING MARKETS, 2003-2008 (CAGR%) 100
FIGURE 44 CHARGED PARTICLE MICROSCOPE MARKET SEGMENTS, 2020 (PERCENT
OF TOTAL SALES) 103
FIGURE 45 SPM MARKET PRODUCT SEGMENTS, 2014 (%) 105
FIGURE 46 SCANNING PROBE MICROSCOPE MARKET SEGMENTS, 2020 (PERCENT OF
TOTAL SALES) 106
FIGURE 47 MICROSCOPE ACCESSORIES AND SUPPLIES MARKET SEGMENTATION,
2014 (%) 108
FIGURE 48 TRENDS IN NUMBER OF MICROSCOPES IN USE WORLDWIDE, 2014-2020
(MILLION UNITS) 108
FIGURE 49 OPTICAL MICROSCOPE MARKET SHARES BY END-USER SEGMENT, 2014
VERSUS 2020 (%) 110
FIGURE 50 CHARGED PARTICLE MICROSCOPE MARKET SHARES BY END-USER
SEGMENT, 2014 VERSUS 2020 (%) 112
FIGURE 51 MICROSCOPE MARKET SHARES BY END-USER SEGMENT, 2014 VERSUS
2020 (%) 113
FIGURE 52 OPTICAL MICROSCOPE GEOGRAPHICAL MARKET SHARES, 2014 VERSUS
2020 (%) 115
FIGURE 53 CHARGED PARTICLE MICROSCOPE GEOGRAPHICAL MARKET SHARES,
2014 VERSUS 2020 (%) 117
FIGURE 54 SCANNING PROBE MICROSCOPE GEOGRAPHICAL MARKET SHARES, 2014
VERSUS 2020 (%) 119
FIGURE 55 MICROSCOPE MARKET SHARES BY END-USER SEGMENT, 2014 VERSUS
2020 (%) 121
FIGURE 56 OPTICAL MICROSCOPY MARKET SHARES, 2014 (%) 124
FIGURE 57 ELECTRON MICROSCOPE MARKET SHARES, 2014 (%) 125
FIGURE 58 FOCUSED ION BEAM MICROSCOPE MARKET SHARES, 2014 (%) 126
FIGURE 59 SCANNING PROBE MICROSCOPE MARKET SHARES, 2014 (%) 126

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