Microelectronic Medical Implants: Products, Technologies and Opportunities

Microelectronic Medical Implants: Products, Technologies and Opportunities

The first microelectronic medical implant (MMI) was introduced over 45 years ago and remains to be the best-known pacemaker. Assisting people with weak or failing hearts in living longer, fuller lives has continued to be a major focus of medical implant R&D. The pacemaker has been followed by a variety of other implantable cardiac devices, including defibrillators, loop recorders, heart assists, and even heart replacements.

Neurostimulators, implantable devices that employ the same principles as pacemakers for the purposes of neural stimulation, have also been introduced. Neurostimulators were used initially for pain relief, but are now being used for other neurological indications ranging from the treatment of urge incontinence to preventing epileptic seizures.

Other therapeutic implantable devices have followed, including bone growth stimulators, drug infusion pumps, and ear implants that provide a semblance of hearing for the deaf. Eye implants that can restore limited vision to people with certain types of blindness are under development and may become a commercial reality around the end of this decade. 
 

INTRODUCTION

MICROELECTRONIC MEDICAL IMPLANTS

STUDY BACKGROUND

STUDY GOALS AND OBJECTIVES

INTENDED AUDIENCE

SCOPE OF THE STUDY

METHODOLOGY AND INFORMATION SOURCES

ANALYST CREDENTIALS

OTHER RELEVANT BCC REPORTS

BCC ONLINE SERVICES

DISCLAIMER

EXECUTIVE SUMMARY

Summary Table:

GLOBAL MARKET FOR MICROELECTRONIC MEDICAL IMPLANTS BY APPLICATION, THROUGH 2012 ($ BILLIONS)

Summary Figure:

GLOBAL MARKET FOR MICROELECTRONIC MEDICAL IMPLANTS BY APPLICATION, 2006-2012 ($ BILLIONS)

OVERVIEW OF MICROELECTRONIC IMPLANTS

GENERAL DESCRIPTION

DEFINITION

HISTORY OF MICROELECTRONIC IMPLANTS

Early Origins

Early Pacemakers

Advances in Pacemaker Technology

First Implantable Defibrillator

Neurostimulators

First Implantable Drug Pump

Cardiac Assist/Replacement Devices

Ear Implants

Eye Implants

TECHNOLOGIES

MINIATURIZATION

MATERIALS

SENSORS

POWER SUPPLIES

RF TECHNOLOGY

APPLICATIONS

CARDIOVASCULAR DISEASE

Table 1 HOSPITALIZATIONS, PHYSICIAN OFFICE VISITS, AND DEATHS DUE TO HEART DISEASE IN THE U.S., 2001-2002*

Brachycardia

Hypertrophic Cardiomyopathy

Tachyarrhythmia

Syncope

Heart Failure

NEUROLOGICAL DISEASES/CONDITIONS

Chronic Pain

Spinal Cord Injuries

Parkinson's Disease

Epilepsy

Depression

Muscle Spasticity

Urge Incontinence

Other Conditions

Alzheimer's Disease

BONE DAMAGE

DIABETES

CANCER

Figure 1 TRENDS IN U.S. CANCER DEATHS, 1998-

IMPAIRED HEARING

BLINDNESS

PRODUCT TYPES

CARDIAC IMPLANT

Pacemakers

Description

Applications

Technology

Manufacturers

Table 2 HEART PACEMAKER MANUFACTURERS

Patent Analysis

Figure 2 PACEMAKER PATENT HOLDERS (% OF TOTAL PACEMAKER PATENTS)

Implantable Cardioverter Defibrillators

Description

Applications

Technology

Manufacturers

Table 3 IMPLANTABLE DEFIBRILLATOR MANUFACTURERS

Patent Analysis

Figure 3 ICD PATENT HOLDERS (%)

Cardiac Resynchronization Therapy Device

Description

Applications

Technology

Manufacturers

Table 4 CARDIAC RESYNCHRONIZATION DEVICE MANUFACTURERS

Patent Analysis

Figure 4 CARDIAC RESYNCHRONIZATION DEVICE PATENT HOLDERS (% OF TOTAL PATENTS ISSUED THROUGH MARCH 1. 2007)

Implantable Loop Recorders

Description

Applications

Technology

Manufacturers

Patent Analysis

Cardiac Replacement/ Assist Devices

Description

Applications

Technology

Table 5 HEART ASSIST DEVICES

Ventricle Assisted

Pulsatile vs. Continuous Flow Pumping

Percutaneous vs. Transcutaneous Devices

Power Source

Other Technical Developments

High-Performance Materials

Greater Longevity

Miniaturization

Manufacturers

Table 6 CARDIAC REPLACEMENT/ASSIST DEVICE MANUFACTURERS

Patent Analysis

Figure 5 CARDIAC ASSISTANCE/REPLACEMENT DEVICE PATENT HOLDERS (PERCENT OF TOTAL U.S. PATENTS)

NEUROSTIMULATORS

Spinal Nerve Stimulators

Description

Applications

Technologies

Spinal Nerve Stimulators for Chronic Pain

Spinal Stimulators for Spinal Cord Injury

Freehand

Vocare

Dobelle Implantable Breathing Pacemaker

Recent Developments in Spinal Nerve Stimulators for SCI

Spinal Nerve Stimulators for Urge Incontinence

Manufacturers

Table 7 SPINAL CORD STIMULATOR MANUFACTURERS

Recent Patents

Vagal Nerve Stimulator

Description

Applications

Technology

Manufacturers

Patent Analysis

Gastric Nerve Stimulation

Description

Applications

Technology

Manufacturers

Patents

Figure 6 GASTRIC ELECTRICAL STIMULATION TECHNOLOGY PATENTS (% OF TOTAL CORTICAL STIMULATION PATENTS)

Cortical Stimulation

Description

Applications

Post-Stroke Recovery

Epilepsy Treatment

Technology

Manufacturers

Patents

Figure 7 CORTICAL STIMULATION TECHNOLOGY PATENTS (% OF TOTAL CORTICAL STIMULATION PATENTS)

Deep Brain Stimulation

Description

Applications

Technology

Manufacturers

Patent Analysis

Figure 8 DEEP BRAIN STIMULATION TECHNOLOGY PATENTS (PERCENT OF TOTAL CORTICAL STIMULATION PATENTS)

SPINAL FUSION STIMULATORS

Description

Applications

Technology

Manufacturers

Table 8 SPINAL FUSION STIMULATOR MANUFACTURERS

Patent Analysis

IMPLANTABLE DRUG DIFFUSION PUMPS

Description

Applications

Technology

Microfluidics

Manufacturers

Table 9 IMPLANTABLE DRUG PUMP MANUFACTURERS

Patent Analysis

EAR IMPLANTS

Cochlear Implants

Description

Applications

Technology

Multi-Channel Cochlear Implants

Single-Electrode Cochlear Implants

Speech Coding

Miniaturization

Hybrid Cochlear Implants

Totally Implantable Cochlear Implants

Manufacturers

Table 10 COCHLEAR IMPLANT MANUFACTURERS

Patent Analysis

Figure 9 COCHLEAR IMPLANT PATENT HOLDERS (%)

Middle Ear Implants

Description

Applications

Technologies

Piezoelectric Middle Ear Implants

Electromagnetic Middle Ear Implants

Other Differences

Manufacturers

Table 11 MIDDLE EAR IMPLANT MANUFACTURERS

Patent Analysis

Figure 10 MIDDLE-EAR IMPLANT PATENT HOLDERS (%)

OCULAR IMPLANTS

Description

Applications

Technologies

Cortical Implants

Retinal Implants

Epi-Retinal Implants

Boston Retinal Implant Project

Intraocular Retinal Prosthesis Group

Second Sight Medical Products, Inc.

Intelligent Medical Implants

Sub-Retinal Implants

Optobionics Corporation

Retina Implant GmbH

Hybrid Implants

Optic Nerve Stimulator

Patents

Figure 11 EYE IMPLANT PATENT HOLDERS (PERCENT OF TOTAL EYE IMPLANT PATENTS)

COMPONENTS AND SUPPLIES

Batteries

Lithium/Iodine Pacemaker Cells

Lithium/Silver Vanadium Oxide Defibrillator Cells

Lithium Carbon Monofluoride Cells

Lithium/Silver Vanadium Oxide/Fluorinated Carbon Cells

Lithium Ion Rechargeable Batteries

Other Technologies

Leads and Electrodes

REGULATORY/ LEGISLATIVE ISSUES

UNITED STATES

EUROPEAN UNION

JAPAN

GLOBAL MARKET FOR MICROELECTRONIC MEDICAL IMPLANTS

SUMMARY

Figure 12 TRENDS IN GLOBAL MARKET FOR MICROELECTRONIC MEDICAL IMPLANTS, 2006-2012 ($ BILLIONS)

DETAILED MARKET ESTIMATES AND PROJECTIONS, 2002-2012

Table 12 GLOBAL MARKET FORECAST FOR MICROELECTRONIC MEDICAL IMPLANTS BY TYPE OF IMPLANT, THROUGH 2012 ($ MILLIONS)

Figure 13 TRENDS IN MICROELECTRONIC MEDICAL IMPLANT APPLICATION MARKET SHARES, 2006 AND 2012 (PERCENT OF TOTAL IMPLANT SALES)

CARDIAC IMPLANTS

Table 13 GLOBAL MARKET FORECAST FOR CARDIAC IMPLANTS, THROUGH 2012 ($ MILLIONS)

Figure 14 TRENDS IN CARDIOVASCULAR IMPLANT MARKET SHARES, 2006-2012 (PERCENT OF TOTAL CARDIO IMPLANT SALES MARKET)

Pacemakers

Historical Sales of Pacemakers

Market Dynamics

Figure 15 RECENT GROWTH OF PACEMAKER SALES VS. OTHER INDICATORS, 2001-2006 (CAGR%)

Projected Sales of Pacemakers

Table 14 GLOBAL MARKET FORECAST FOR PACEMAKERS, THROUGH 2012 ($ MILLIONS)

Implanted Cardioverter Defibrillators

Historical Sales

Market Dynamics

New Indications

Low Market Penetration

Projected Sales

Table 15 GLOBAL MARKET FORECAST FOR ICD, THROUGH 2012 ($ MILLIONS)

Cardiac Resynchronization Therapy Devices

Implantable Loop Recorders

Historical Sales

Market Dynamics

Number of New Syncope Cases

Table 16 U.S. POPULATION AGED 55 AND OLDER, THROUGH

Diagnostic Use of ILR

Projected Sales

Table 17 GLOBAL MARKET FORECAST FOR ILR, THROUGH 2012 ($ MILLIONS)

Cardiac Assist/ Replacement Devices

Historical Sales

Market Dynamics

Bridge to Transplant Applications

Destination Therapy Applications

Rate of Technology Adoption

Insurance Coverage

Constraints on Number of Qualified Surgeons

Projected Sales

Table 18 GLOBAL MARKET FORECAST FOR CARDIAC ASSISTS, THROUGH 2012 ($ MILLIONS)

NEUROSTIMULATORS

Table 19 GLOBAL MARKET FORECAST FOR NEUROSTIMULATORS, THROUGH 2012 ($ MILLIONS)

Figure 16 IMPLANTED NEUROSTIMULATOR MARKET SHARES, 2006 VS. 2012 (PERCENT OF IMPLANTED NEUROSTIMULATOR MARKET)

Spinal Nerve Stimulators

Table 20 GLOBAL MARKET FORECAST FOR SPINAL NERVE STIMULATORS, THROUGH 2012 ($ MILLIONS)

Spinal Nerve Stimulators for Chronic Pain

Historical Sales

Market Dynamics

Figure 17 SPINAL NERVE STIMULATOR CHRONIC PAIN MANAGEMENT MARKET PENETRATION, 2006 (%)

Projected Sales

Table 21 GLOBAL MARKET FORECAST FOR SPINAL NERVE STIMULATORS USED FOR CHRONIC PAIN MANAGEMENT, THROUGH 2012 ($ MILLIONS)

Spinal Nerve Stimulators for Spinal Cord Injury

Historical Sales

Market Dynamics

Projected Sales

Table 22 GLOBAL MARKET FORECAST FOR SPINAL NERVE STIMULATORS USED FOR SPINAL CORD INJURY, THROUGH 2012 ($ MILLIONS)

Spinal Nerve Stimulators for Urge Incontinence

Historical Sales

Market Dynamics

Projected Sales

Table 23 GLOBAL MARKET FORECAST FOR SPINAL STIMULATORS FOR MANAGING URGE INCONTINENCE, THROUGH 2012 ($ MILLIONS)

Vagal Nerve Stimulators

Historical Sales

Market Dynamics

Epilepsy Cases

Figure 18 VNS EPILEPSY MARKET PENETRATION, 2006 (%)

Depression

Future Sales

Table 24 GLOBAL MARKET FORECAST FOR VNS STIMULATORS, THROUGH 2012 ($ MILLIONS)

Deep Brain Stimulators

Historical Sales

Market Dynamics

Figure 19 DEEP BRAIN STIMULATION IMPLANT MARKET PENETRATION, 2006 (%)

Projected Sales

Table 25 GLOBAL MARKET FORECAST FOR DEEP BRAIN STIMULATORS, THROUGH 2012 ($ MILLIONS)

SPINAL FUSION STIMULATORS

Historical Sales

Market Dynamics

Projected Sales

Table 26 GLOBAL MARKET FORECAST FOR IMPLANTABLE SPINAL FUSION STIMULATORS, THROUGH 2012 ($ MILLIONS)

DRUG PUMPS

Historical Sales

Market Dynamics

Figure 20 GROWTH IN SALES OF IMPLANTABLE DRUG PUMPS VS. MAJOR TARGET MARKETS, 1998-2006 (CAGR%)

Figure 20 (CONTINUED)

Projected Sales

Table 27 GLOBAL MARKET FORECAST FOR IMPLANTABLE DRUG PUMPS, THROUGH 2012 ($ MILLIONS)

HEARING IMPLANTS

Table 28 GLOBAL MARKET FORECAST FOR HEARING IMPLANTS, THROUGH 2012 ($ MILLIONS)

Cochlear Implants

Historical Sales

Market Dynamics

Figure 21 COCHLEAR IMPLANT MARKET PENETRATION, 2006 (%)

Projected Sales

Table 29 GLOBAL MARKET FORECAST FOR COCHLEAR IMPLANTS, THROUGH 2012 ($ MILLIONS)

Middle Ear Implants

Historical Sales

Market Dynamics

Projected Sales

Table 30 GLOBAL MARKET FORECAST FOR MIDDLE EAR IMPLANTS, THROUGH 2012 ($ MILLIONS)

EYE IMPLANTS

Historical Sales

Market Dynamics

Projected Sales

ACCESSORIES AND SUPPLIES

Historical Sales

Market Dynamics

Projected Sales

Table 31 GLOBAL MARKET FORECAST FOR IMPLANTABLE LEADS AND ELECTRODES, THROUGH 2012 ($ MILLIONS)

INDUSTRY STRUCTURE AND COMPETITION

MARKET SHARES

CARDIAC RHYTHM MANAGEMENT DEVICES

Pacemakers

Figure 22 CARDIAC PACEMAKER MARKET SHARES, 2006 (PERCENT OF TOTAL SEGMENT SALES)

Implantable Cardioverter Defibrillators

Figure 23 IMPLANTABLE CARDIOVERTER DEFIBRILLATOR MARKET SHARES, 2006 (PERCENT OF TOTAL SEGMENT SALES)

Implantable Loop Recorders

Heart Assist/ Replacement Devices

Figure 24 IMPLANTABLE HEART ASSIST/REPLACEMENT DEVICE MARKET SHARES, 2006 (PERCENT OF TOTAL SEGMENT SALES)

NEUROSTIMULATORS

Spinal Stimulators

Figure 25 SPINAL STIMULATOR MARKET SHARES, 2006 (PERCENT OF TOTAL SEGMENT SALES)

SPINAL FUSION STIMULATORS

Figure 26 SPINAL FUSION STIMULATOR MARKET SHARES, 2006 (PERCENT OF TOTAL SEGMENT SALES)

IMPLANTABLE DRUG INFUSION PUMPS

Figure 27 IMPLANTABLE DRUG PUMP MARKET SHARES, 2006 (PERCENT OF TOTAL SEGMENT SALES)

EAR IMPLANTS

Cochlear Implants

Figure 28 COCHLEAR IMPLANT MARKET SHARES, 2006 (PERCENT OF TOTAL SEGMENT SALES)

VENDOR PROFILES

ABIOMED, INC.

Table 32 ABIOMED FINANCIAL PERFORMANCE, THROUGH 2006 ($ MILLIONS)

ADVANCED BIONICS CORP.

ADVANCED NEUROMODULATION SYSTEMS, INC.

Table 33 ADVANCED NEUROMODULATION SYSTEMS FINANCIAL PERFORMANCE, THROUGH 2006* ($ MILLIONS)

ALLHEAR, INC.

ARROW INTERNATIONAL

BIOMET, INC.

BIOPHAN TECHNOLOGIES, INC.

BIOTRONIK GMBH

CLEVELAND FES CENTER

COCHLEAR, LTD.

CYBERONICS, INC.

Table 34 CYBERONICS, INC. FINANCIAL PERFORMANCE, THROUGH 2006 ($ MILLIONS)

THE DOBELLE INSTITUTE

ELA MEDICAL

ENVOY MEDICAL

FINETECH MEDICAL, LTD.

GUIDANT CORP.

Table 35 GUIDANT CORP. FINANCIAL PERFORMANCE, THROUGH 2005 ($ MILLIONS)

MED-EL

MEDTRONICS

Table 36 MEDTRONIC SALES IN SELECTED BUSINESS SEGMENTS, THROUGH 2006 ($ BILLIONS)

MICROMED TECHNOLOGY, INC.

MIV THERAPEUTICS, INC.

NEOPRAXIS, PTY. LTD.

NEUROCONTROL, INC.

NEUROPACE, INC.

OTOLOGICS, LLC

SOUNDTEC, INC.

ST. JUDE MEDICAL, INC.

Table 37 ST. JUDE MEDICAL FINANCIAL PERFORMANCE, THROUGH 2006 ($ MILLIONS)

SYMPHONIX DEVICES

THORATEC CORP.

WILSON GREATBATCH TECHNOLOGIES, INC.

Table 38 WILSON GREATBATCH IMD BATTERY SALES, THROUGH 2005 ($ MILLIONS)

WORLDHEART CORP.

Table 39 WORLDHEART CORP. FINANCIAL PERFORMANCE, THROUGH 2005 ($ MILLIONS)

LIST OF TABLES

Summary Table:

GLOBAL MARKET FOR MICROELECTRONIC MEDICAL IMPLANTS BY APPLICATION, THROUGH 2012 ($ BILLIONS)

Table 1 HOSPITALIZATIONS, PHYSICIAN OFFICE VISITS, AND DEATHS DUE TO HEART DISEASE IN THE U.S., 2001-2002*

Table 2 HEART PACEMAKER MANUFACTURERS

Table 3 IMPLANTABLE DEFIBRILLATOR MANUFACTURERS

Table 4 CARDIAC RESYNCHRONIZATION DEVICE MANUFACTURERS

Table 5 HEART ASSIST DEVICES

Table 6 CARDIAC REPLACEMENT/ASSIST DEVICE MANUFACTURERS

Table 7 SPINAL CORD STIMULATOR MANUFACTURERS

Table 8 SPINAL FUSION STIMULATOR MANUFACTURERS

Table 9 IMPLANTABLE DRUG PUMP MANUFACTURERS

Table 10 COCHLEAR IMPLANT MANUFACTURERS

Table 11 MIDDLE EAR IMPLANT MANUFACTURERS

Table 12 GLOBAL MARKET FORECAST FOR MICROELECTRONIC MEDICAL IMPLANTS BY TYPE OF IMPLANT, THROUGH 2012 ($ MILLIONS)

Table 13 GLOBAL MARKET FORECAST FOR CARDIAC IMPLANTS, THROUGH 2012 ($ MILLIONS)

Table 14 GLOBAL MARKET FORECAST FOR PACEMAKERS, THROUGH 2012 ($ MILLIONS)

Table 15 GLOBAL MARKET FORECAST FOR ICD, THROUGH 2012 ($ MILLIONS)

Table 16 U.S. POPULATION AGED 55 AND OLDER, THROUGH

Table 17 GLOBAL MARKET FORECAST FOR ILR, THROUGH 2012 ($ MILLIONS)

Table 18 GLOBAL MARKET FORECAST FOR CARDIAC ASSISTS, THROUGH 2012 ($ MILLIONS)

Table 19 GLOBAL MARKET FORECAST FOR NEUROSTIMULATORS, THROUGH 2012 ($ MILLIONS)

Table 20 GLOBAL MARKET FORECAST FOR SPINAL NERVE STIMULATORS, THROUGH 2012 ($ MILLIONS)

Table 21 GLOBAL MARKET FORECAST FOR SPINAL NERVE STIMULATORS USED FOR CHRONIC PAIN MANAGEMENT, THROUGH 2012 ($ MILLIONS)

Table 22 GLOBAL MARKET FORECAST FOR SPINAL NERVE STIMULATORS USED FOR SPINAL CORD INJURY, THROUGH 2012 ($ MILLIONS)

Table 23 GLOBAL MARKET FORECAST FOR SPINAL STIMULATORS FOR MANAGING URGE INCONTINENCE, THROUGH 2012 ($ MILLIONS)

Table 24 GLOBAL MARKET FORECAST FOR VNS STIMULATORS, THROUGH 2012 ($ MILLIONS)

Table 25 GLOBAL MARKET FORECAST FOR DEEP BRAIN STIMULATORS, THROUGH 2012 ($ MILLIONS)

Table 26 GLOBAL MARKET FORECAST FOR IMPLANTABLE SPINAL FUSION STIMULATORS, THROUGH 2012 ($ MILLIONS)

Table 27 GLOBAL MARKET FORECAST FOR IMPLANTABLE DRUG PUMPS, THROUGH 2012 ($ MILLIONS)

Table 28 GLOBAL MARKET FORECAST FOR HEARING IMPLANTS, THROUGH 2012 ($ MILLIONS)

Table 29 GLOBAL MARKET FORECAST FOR COCHLEAR IMPLANTS, THROUGH 2012 ($ MILLIONS)

Table 30 GLOBAL MARKET FORECAST FOR MIDDLE EAR IMPLANTS, THROUGH 2012 ($ MILLIONS)

Table 31 GLOBAL MARKET FORECAST FOR IMPLANTABLE LEADS AND ELECTRODES, THROUGH 2012 ($ MILLIONS)

Table 32 ABIOMED FINANCIAL PERFORMANCE, THROUGH 2006 ($ MILLIONS)

Table 33 ADVANCED NEUROMODULATION SYSTEMS FINANCIAL PERFORMANCE, THROUGH 2006* ($ MILLIONS)

Table 34 CYBERONICS, INC. FINANCIAL PERFORMANCE, THROUGH 2006 ($ MILLIONS)

Table 35 GUIDANT CORP. FINANCIAL PERFORMANCE, THROUGH 2005 ($ MILLIONS)

Table 36 MEDTRONIC SALES IN SELECTED BUSINESS SEGMENTS, THROUGH 2006 ($ BILLIONS)

Table 37 ST. JUDE MEDICAL FINANCIAL PERFORMANCE, THROUGH 2006 ($ MILLIONS)

Table 38 WILSON GREATBATCH IMD BATTERY SALES, THROUGH 2005 ($ MILLIONS)

Table 39 WORLDHEART CORP. FINANCIAL PERFORMANCE, THROUGH 2005 ($ MILLIONS)

LIST OF FIGURES

Summary Figure:

GLOBAL MARKET FOR MICROELECTRONIC MEDICAL IMPLANTS BY APPLICATION, 2006-2012 ($ BILLIONS)

Figure 1 TRENDS IN U.S. CANCER DEATHS, 1998-2006

Figure 2 PACEMAKER PATENT HOLDERS (% OF TOTAL PACEMAKER PATENTS)

Figure 3 ICD PATENT HOLDERS (%)

Figure 4 CARDIAC RESYNCHRONIZATION DEVICE PATENT HOLDERS (% OF TOTAL PATENTS ISSUED THROUGH MARCH 1. 2007)

Figure 5 CARDIAC ASSISTANCE/REPLACEMENT DEVICE PATENT HOLDERS (PERCENT OF TOTAL U.S. PATENTS)

Figure 6 GASTRIC ELECTRICAL STIMULATION TECHNOLOGY PATENTS (% OF TOTAL CORTICAL STIMULATION PATENTS)

Figure 7 CORTICAL STIMULATION TECHNOLOGY PATENTS (% OF TOTAL CORTICAL STIMULATION PATENTS)

Figure 8 DEEP BRAIN STIMULATION TECHNOLOGY PATENTS (PERCENT OF TOTAL CORTICAL STIMULATION PATENTS)

Figure 9 COCHLEAR IMPLANT PATENT HOLDERS (%)

Figure 10 MIDDLE-EAR IMPLANT PATENT HOLDERS (%)

Figure 11 EYE IMPLANT PATENT HOLDERS (PERCENT OF TOTAL EYE IMPLANT PATENTS)

Figure 12 TRENDS IN GLOBAL MARKET FOR MICROELECTRONIC MEDICAL IMPLANTS, 2006-2012 ($ BILLIONS)

Figure 13 TRENDS IN MICROELECTRONIC MEDICAL IMPLANT APPLICATION MARKET SHARES, 2006 AND 2012 (PERCENT OF TOTAL IMPLANT SALES)

Figure 14 TRENDS IN CARDIOVASCULAR IMPLANT MARKET SHARES, 2006-2012 (PERCENT OF TOTAL CARDIO IMPLANT SALES MARKET)

Figure 15 RECENT GROWTH OF PACEMAKER SALES VS. OTHER INDICATORS, 2001-2006 (CAGR%)

Figure 16 IMPLANTED NEUROSTIMULATOR MARKET SHARES, 2006 VS. 2012 (PERCENT OF IMPLANTED NEUROSTIMULATOR MARKET)

Figure 17 SPINAL NERVE STIMULATOR CHRONIC PAIN MANAGEMENT MARKET PENETRATION, 2006 (%)

Figure 18 VNS EPILEPSY MARKET PENETRATION, 2006 (%)

Figure 19 DEEP BRAIN STIMULATION IMPLANT MARKET PENETRATION, 2006 (%)

Figure 20 GROWTH IN SALES OF IMPLANTABLE DRUG PUMPS VS. MAJOR TARGET MARKETS, 1998-2006 (CAGR%)

Figure 21 COCHLEAR IMPLANT MARKET PENETRATION, 2006 (%)

Figure 22 CARDIAC PACEMAKER MARKET SHARES, 2006 (PERCENT OF TOTAL SEGMENT SALES)

Figure 23 IMPLANTABLE CARDIOVERTER DEFIBRILLATOR MARKET SHARES, 2006 (PERCENT OF TOTAL SEGMENT SALES)

Figure 24 IMPLANTABLE HEART ASSIST/REPLACEMENT DEVICE MARKET SHARES, 2006 (PERCENT OF TOTAL SEGMENT SALES)

Figure 25 SPINAL STIMULATOR MARKET SHARES, 2006 (PERCENT OF TOTAL SEGMENT SALES)

Figure 26 SPINAL FUSION STIMULATOR MARKET SHARES, 2006 (PERCENT OF TOTAL SEGMENT SALES)

Figure 27 IMPLANTABLE DRUG PUMP MARKET SHARES, 2006 (PERCENT OF TOTAL SEGMENT SALES)

Figure 28 COCHLEAR IMPLANT MARKET SHARES, 2006 (PERCENT OF TOTAL SEGMENT SALES)