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Global Gene Amplification Technologies Industry

  • February 2012
  • -
  • Global Industry Analysts

This report analyzes the worldwide markets for Gene Amplification Technologies in US$ Million by the following Product Segments: Polymerase Chain Reaction, and Other Gene Amplification Technologies. The report provides separate comprehensive analytics for the US, Canada, Japan, Europe, and Rest of World. Annual estimates and forecasts are provided for the period 2009 through 2017. Also, a six-year historic analysis is provided for these markets. The report profiles 90 companies including many key and niche players such as Abbott Laboratories, Becton, Dickinson and Company, bioMerieux, Bio-Rad Laboratories, Cepheid, Life Technologies Corp., QIAGEN N.V, Roche Diagnostics, Rubicon Genomics, and Takara Bio, Inc. Market data and analytics are derived from primary and secondary research. Company profiles are primarily based upon search engine sources in the public domain.

Table Of Contents

Global Gene Amplification Technologies Industry




I. INTRODUCTION, METHODOLOGY and PRODUCT DEFINITIONS
Study Reliability and Reporting Limitations I-1
Disclaimers I-2
Data Interpretation and Reporting Level I-2
Quantitative Techniques and Analytics I-3
Product Definitions and Scope of Study I-3
Definitions I-3
Polymerase Chain Reaction I-3
Other Gene Amplification Technologies I-3


II. EXECUTIVE SUMMARY

1. INDUSTRY OVERVIEW II-1
PCR Dominates Amplification Technologies II-1
Growth Prospects Live in PCR Market despite Competition II-1
Miniaturization - The Next Big Focus II-1
Critical in Diagnostic Procedures II-2
Leading Players II-2

2. TECHNOLOGY OVERVIEW II-3
Definition of Gene Amplification II-3
Target vs. Signal Amplification II-3
Available Types of Gene Amplification Technologies II-3
Polymerase Chain Reaction II-3
Reagents and Equipment required for PCR II-4
Reaction Steps II-4
Denaturation II-4
Annealing II-4
Extension II-4
Detection of Amplified Product/DNA II-5
(QandQ) PCR II-5
Reverse Transcriptase PCR (RT-PCR) II-6
Alternative Technologies to PCR II-6
OmniPlex II-6
Strand Displacement Amplification II-7
Ligase Chain Reaction II-7
LCR Involves a Cyclic Two-Step Reaction II-7
Gene Amplification Technology (GAT) II-7
Hybrid Capture II-7
Isothermal DNA Amplification Techniques II-8
Rolling circle Amplification in Diagnostics II-8
Ican Isothermal Gene Amplification Technology II-8
BioHelix HDA Technology II-8
Other Amplification Technologies II-8
Signal Amplification Technology II-8
Transcription Mediated Amplification II-9
DNA cleavage-based signal amplification II-9
Ramification Amplification Method II-9

3. END-USE MARKET ANALYSIS II-10
Medical and Diagnostics II-10
Role of Amplification Technology in the Diagnoses of
Infectious Diseases II-10
Diagnosis of Infectious Diseases by PCR II-10
Detection of Antimicrobial Resistance II-11
PCR Based Nucleic Acid Amplification for Detection of
Antimicrobial Agents II-11
Nucleic Acid Amplification Testing (NAT) II-11
Nucleic Acid Amplification Methods II-12
DNA Amplification Technology in the Diagnosis of Infectious
Diseases II-12
Forensic and Paternity Testing II-12
Food Safety II-13

4. PRODUCT INNOVATIONS/LAUNCHES II-14
DuPont Qualicon Launches New BAX® System Real-Time PCR Assay II-14
Rubicon Genomics Launches PicoPlex Single Cell WGA Kit II-14
NuGEN Unveils WT-OvationTM RNA Amplification System for Whole
-Transcriptome Gene Expression Analysis II-14
DuPont Qualicon Obtains Approval from Russian Federal Consumer
Rights Protection and Human Health Control Service for BAXâ„¢
System II-15
DuPont Qualicon Receives Approval from the General
Administration of Quality Supervision, Inspection and
Quarantine for BAX® system II-15
Seegene Enters into Partnership with Shimadzu II-16
Bio-Rad Launches New CFX96 PCR Detection System II-16

5. PRODUCT INNOVATIONS/LAUNCHES IN RECENT PAST - A PERSPECTIVE
BUILDER II-17
Roche Introduces Genome Sequencer FLX System II-17
QIAGEN Launches TopTaq DNA Polymerase II-17
Applied Biosystems Introduces TaqMan Array Human MicroRNA Panel II-17
Spartan Introduces Spartan DX II-18
Applied Biosystems Launches Forensic Tools II-18
Applied Biosystems Introduces StepOne Real-Time PCR System II-18
Sigma-Aldrich Unveils GenomePlex Tissue Whole Genome
Amplification Kit II-19
QIAGEN Rolls Out Wide RNAi and SYBR® Green-based RT- PCR II-19
Applied Biosystems Launches 7500 Fast Real-Time PCR System II-19
Applied Biosystems Launches 9800 Fast PCR System II-20
7900HT Fast Real-Time PCR System from Applied Biosystems II-20
Enzo Life Sciences Introduces New Advanced Amplification
Technology II-20
Applied Biosystems Unveils AmpFSTR® Yfiler™ PCR Amplification Kit II-21
Amersham Launches GenomiPhi II-21
Rubicon Genomics Launches GenomePlex WGA II-21
Agilent Introduces Amplification Kit II-21
Linden Introduces Snapshot mRNA II-22
Rubicon Launches OmniPlexâ„¢ II-22

6. RECENT INDUSTRY ACTIVITY II-23
QIAGEN Acquires Rights to 70 Molecular Food Safety Tests from ifp II-23
Life Technologies to Acquire Geneart II-23
Thermo Fisher Scientific Takes Over Finnzymes II-23
Abbott Inks Agreement with GlaxoSmithKline for Developing
Molecular Diagnostic Test II-23
DXS Purchases License for P13K Gene from Johns Hopkins University II-24
Qiagen Acquires SABiosciences II-24
DuPont Qualicon Obtains License from DxS for Scorpions®
Technology II-24
BD Takes Over HandyLab II-25
Life Technologies Takes Over BioTrove II-25
Merck Merges with Schering-Plough II-25
QIAGEN Acquires Licenses from Idaho Technology and Roche II-25
Response Genetics Inks Non-Exclusive Agreement with Roche
Diagnostics II-26
Invitrogen Announces Merger with Applied Biosystems II-26
Hologic Acquires Third Wave Technologies II-26
BIOTECON Acquires Roche's Technology License II-26
QIAGEN Signs a Global Licensing Agreement with BioHelix II-27
BioTrove and Gene Express Receive NIH Grant for Innovative
Bio-experimentation II-27

7. CORPORATE ACTIVITY IN THE RECENT PAST - A PERSPECTIVE BUILDER II-28
SuperArray Bioscience Inks License Agreement with Applied
Biosystems II-28
Merck Capital Takes Over Minority Interest in High Throughput
Genomics II-28
NuGEN Enters into a Service Agreement with ExonHit II-28
Qiagen Enters into License Agreements with Roche and Ortho-
Clinical II-29
Agilent Takes Over Stratagene II-29
Eiken Chemical Inks Licensing Agreement with Meridian Bioscience II-29
Sigma-Aldrich Acquires JRH II-30
Sigma-Aldrich Snaps Up Proligo II-30
Beckman Acquires Agencourt II-30
Roche Diagnostics and Applera Corporation Expand PCR Licensing
Program II-30
Mount and Hamilton Receive Patent II-30
Invitrogen Bags License from Applied Biosystems II-30
OriGene to Access TrueClone II-31
Orchid BioSciences to Turn into Orchid Cellmark II-31
QIAGEN Purchases Assets of Molecular Staging II-31
Cepheid, Applied Biosystems and Celera Diagnostics Sign Patent
License Agreement II-31
Abbott Enters into Agreement with BioGenex II-32
Roche Inks Licensing Agreement with Incyte Corp II-32
Rubicon Genomics Signs Licensing Agreement with Sigma-Aldrich II-32
BioMerieux Teams-up with Cepheid II-32
Molecular Staging Collaborates with Eli Lilly II-32
Pacific Biometrics Inc. Receives Gene Amplification Patent II-32
Rubicon Introduces Service for Genome Amplification II-33
Takara Obtains Patent for New Amplification Method II-33

8. FOCUS ON SELECT GLOBAL PLAYERS II-34
Abbott Laboratories (US) II-34
Becton, Dickinson and Company (US) II-34
bioMerieux (France) II-34
Bio-Rad Laboratories (US) II-35
Cepheid (US) II-35
Life Technologies Corp. (US) II-35
QIAGEN N.V. (The Netherlands) II-36
Roche Diagnostics (Switzerland) II-36
Rubicon Genomics (US) II-37
Takara Bio, Inc. II-37

9. GLOBAL MARKET PERSPECTIVE II-38
Table 1: World Recent Past, Current and Future Market Analysis
for Gene Amplification Technologies by Geographic Region - US,
Canada, Japan, Europe, and Rest of World Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2009 through 2017 (includes corresponding Graph/Chart) II-38

Table 2: World Historic Review for Gene Amplification
Technologies by Geographic Region - US, Canada, Japan, Europe,
and Rest of World Markets Independently Analyzed with Annual
Sales Figures in US$ Million for Years 2003 through
2008(includes corresponding Graph/Chart) II-39

Table 3: World 15-Year Perspective for Gene Amplification
Technologies by Geographic Region - Percentage Breakdown of
Dollar Sales for US, Canada, Japan, Europe, and Rest of World
Markets for Years 2003, 2011 and 2017 (includes corresponding
Graph/Chart) II-40

Table 4: World Recent Past, Current and Future Market Analysis
for Polymerase Chain Reaction (PCR) by Geographic Region - US,
Canada, Japan, Europe, and Rest of World Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2009 through 2017 (includes corresponding Graph/Chart) II-41

Table 5: World Historic Review for Polymerase Chain Reaction
(PCR) by Geographic Region - US, Canada, Japan, Europe, and
Rest of World Markets Independently Analyzed with Annual Sales
Figures in US$ Million for Years 2003 through 2008(includes
corresponding Graph/Chart) II-42

Table 6: World 15-Year Perspective for Polymerase Chain
Reaction (PCR) by Geographic Region - Percentage Breakdown of
Dollar Sales for US, Canada, Japan, Europe, and Rest of World
Markets for Years 2003, 2011 and 2017 (includes corresponding
Graph/Chart) II-43

Table 7: World Recent Past, Current and Future Market Analysis
for Other Gene Amplification Technologies by Geographic Region
- US, Canada, Japan, Europe, and Rest of World Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2009 through 2017 (includes corresponding
Graph/Chart) II-44

Table 8: World Historic Review for Other Gene Amplification
Technologies by Geographic Region - US, Canada, Japan, Europe,
and Rest of World Markets Independently Analyzed with Annual
Sales Figures in US$ Million for Years 2003 through
2008(includes corresponding Graph/Chart) II-45

Table 9: World 15-Year Perspective for Other Gene
Amplification Technologies by Geographic Region - Percentage
Breakdown of Dollar Sales for US, Canada, Japan, Europe, and
Rest of World Markets for Years 2003, 2011 and 2017(includes
corresponding Graph/Chart) II-46


III. MARKET

1. THE UNITED STATES III-1
A.Market Analysis III-1
Real-Time PCR Market in North America: A Primer III-1
Table 10: Leading Suppliers of Individual qPCR Reagents in
North America (2008): Percentage Dollar Share Breakdown of
Invitrogen, Applied Biosystems, Roche Applied, Bio-Rad/ MJ,
BD Clontech, Promega, Amblon, NEB, Qiagen, and Others
(includes corresponding Graph/Chart) III-1
Key Factors (Ranked in Order) in Selection of Real-Time/
qPCR Platforms Manufacturers III-2
Top 10 Research Applications of Real-Time Quantitative PCR
(qPCR) in North America III-2
B.Market Analytics III-3
Table 11: US Recent Past, Current and Future Analysis for Gene
Amplification Technologies by Segment - Polymerase Chain
Reaction (PCR) and Other Gene Amplification Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2009 through 2017 (includes corresponding
Graph/Chart) III-3

Table 12: US Historic Review for Gene Amplification
Technologies by Segment - Polymerase Chain Reaction (PCR)
and Other Gene Amplification Markets Independently Analyzed
with Annual Sales Figures in US$ Million for Years 2003
through 2008 (includes corresponding Graph/Chart) III-4

Table 13: US 15-Year Perspective for Gene Amplification
Technologies by Segment - Percentage Breakdown of Dollar
Sales for Polymerase Chain Reaction (PCR) and Other Gene
Amplification Markets for Years 2003, 2011 and 2017 (includes
corresponding Graph/Chart) III-5

2. CANADA III-6
Market Analysis III-6
Table 14: Canadian Recent Past, Current and Future Analysis
for Gene Amplification Technologies by Segment - Polymerase
Chain Reaction (PCR) and Other Gene Amplification Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2009 through 2017 (includes corresponding
Graph/Chart) III-6

Table 15: Canadian Historic Review for Gene Amplification
Technologies by Segment - Polymerase Chain Reaction (PCR)
and Other Gene Amplification Markets Independently Analyzed
with Annual Sales Figures in US$ Million for Years 2003
through 2008 (includes corresponding Graph/Chart) III-7

Table 16: Canadian 15-Year Perspective for Gene
Amplification Technologies by Segment - Percentage Breakdown
of Dollar Sales for Polymerase Chain Reaction (PCR) and
Other Gene Amplification Markets for Years 2003, 2011 and 2017
(includes corresponding Graph/Chart) III-8

3. JAPAN III-9
Market Analysis III-9
Table 17: Japanese Recent Past, Current and Future nalysis for
Gene Amplification Technologies by Segment - Polymerase
Chain Reaction (PCR) and Other Gene Amplification Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2009 through 2017 (includes corresponding
Graph/Chart) III-9

Table 18: Japanese Historic Review for Gene Amplification
Technologies by Segment - Polymerase Chain Reaction (PCR)
and Other Gene Amplification Markets Independently Analyzed
with Annual Sales Figures in US$ Million for Years 2003
through 2008 (includes corresponding Graph/Chart) III-10

Table 19: Japanese 15-Year Perspective for Gene
Amplification Technologies by Segment - Percentage Breakdown
of Dollar Sales for Polymerase Chain Reaction (PCR) and
Other Gene Amplification Markets for Years 2003, 2011 and 2017
(includes corresponding Graph/Chart) III-11

4. EUROPE III-12
Market Analysis III-12
Table 20: European Recent Past, Current and Future Analysis
for Gene Amplification Technologies by Geographic Region -
France, Germany, UK, Italy, and Rest of Europe Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2009 through 2017 (includes corresponding
Graph/Chart) III-12

Table 21: European Historic Review for Gene Amplification
Technologies by Geographic Region - France, Germany, UK,
Italy, and Rest of Europe Markets Independently Analyzed
with Annual Sales Figures in US$ Million for Years 2003
through 2008 (includes corresponding Graph/Chart) III-13

Table 22: European 15-Year Perspective for Gene
Amplification Technologies by Geographic Region - Percentage
Breakdown of Dollar Sales for France, Germany, UK, Italy, and
Rest of Europe Markets for Years 2003, 2011 and 2017 (includes
corresponding Graph/Chart) (includes corresponding
Graph/Chart) III-14

Table 23: European Recent Past, Current and Future Analysis
for Gene Amplification Technologies by Segment - Polymerase
Chain Reaction (PCR) and Other Gene Amplification Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2009 through 2017 (includes corresponding
Graph/Chart) III-15

Table 24: European Historic Review for Gene Amplification
Technologies by Segment - Polymerase Chain Reaction (PCR)
and Other Gene Amplification Markets Independently Analyzed
with Annual Sales Figures in US$ Million for Years 2003
through 2008 (includes corresponding Graph/Chart) III-16

Table 25: European 15-Year Perspective for Gene
Amplification Technologies by Segment - Percentage Breakdown
of Dollar Sales for Polymerase Chain Reaction (PCR) and
Other Gene Amplification Markets for Years 2003, 2011 and 2017
(includes corresponding Graph/Chart) III-17

4a. FRANCE III-18
Market Analysis III-18
Table 26: French Recent Past, Current and Future Analysis for
Gene Amplification Technologies by Segment - Polymerase
Chain Reaction (PCR) and Other Gene Amplification Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2009 through 2017 (includes corresponding
Graph/Chart) III-18

Table 27: French Historic Review for Gene Amplification
Technologies by Segment - Polymerase Chain Reaction (PCR)
and Other Gene Amplification Markets Independently Analyzed
with Annual Sales Figures in US$ Million for Years 2003
through 2008 (includes corresponding Graph/Chart) III-19

Table 28: French 15-Year Perspective for Gene Amplification
Technologies by Segment - Percentage Breakdown of Dollar
Sales for Polymerase Chain Reaction (PCR) and Other Gene
Amplification Markets for Years 2003, 2011 and 2017 (includes
corresponding Graph/Chart) III-20

4b. GERMANY III-21
Market Analysis III-21
Table 29: German Recent Past, Current and Future Analysis for
Gene Amplification Technologies by Segment - Polymerase
Chain Reaction (PCR) and Other Gene Amplification Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2009 through 2017 (includes corresponding
Graph/Chart) III-21

Table 30: German Historic Review for Gene Amplification
Technologies by Segment - Polymerase Chain Reaction (PCR)
and Other Gene Amplification Markets Independently Analyzed
with Annual Sales Figures in US$ Million for Years 2003
through 2008(includes corresponding Graph/Chart) III-22

Table 31: German 15-Year Perspective for Gene Amplification
Technologies by Segment - Percentage Breakdown of Dollar
Sales for Polymerase Chain Reaction (PCR) and Other Gene
Amplification Markets for Years 2003, 2011 and 2017 (includes
corresponding Graph/Chart) III-23

4c. ITALY III-24
Market Analysis III-24
Table 32: Italian Recent Past, Current and Future Analysis for
Gene Amplification Technologies by Segment - Polymerase
Chain Reaction (PCR) and Other Gene Amplification Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2009 through 2017 (includes corresponding
Graph/Chart) III-24

Table 33: Italian Historic Review for Gene Amplification
Technologies by Segment - Polymerase Chain Reaction (PCR)
and Other Gene Amplification Markets Independently Analyzed
with Annual Sales Figures in US$ Million for Years 2003
through 2008(includes corresponding Graph/Chart) III-25

Table 34: Italian 15-Year Perspective for Gene Amplification
Technologies by Segment - Percentage Breakdown of Dollar
Sales for Polymerase Chain Reaction (PCR) and Other Gene
Amplification Markets for Years 2003, 2011 and 2017 (includes
corresponding Graph/Chart) III-26

4d. THE UNITED KINGDOM III-27
Market Analysis III-27
Table 35: UK Recent Past, Current and Future Analysis for Gene
Amplification Technologies by Segment - Polymerase Chain
Reaction (PCR) and Other Gene Amplification Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2009 through 2017 (includes corresponding
Graph/Chart) III-27

Table 36: UK Historic Review for Gene Amplification
Technologies by Segment - Polymerase Chain Reaction (PCR)
and Other Gene Amplification Markets Independently Analyzed
with Annual Sales Figures in US$ Million for Years 2003
through 2008 (includes corresponding Graph/Chart) III-28

Table 37: UK 15-Year Perspective for Gene Amplification
Technologies by Segment - Percentage Breakdown of Dollar
Sales for Polymerase Chain Reaction (PCR) and Other Gene
Amplification Markets for Years 2003, 2011 and 2017 (includes
corresponding Graph/Chart) III-29

4e. REST OF EUROPE III-30
Market Analysis III-30
Table 38: Rest of Europe Market for Gene Amplification
Technologies - Recent Past, Current and Future Market Analysis
by Segment for Polymerase Chain Reaction (PCR) and Other
Gene Amplification Markets Independently Analyzed with
Annual Sales Figures in US$ Million for Years 2009 through
2017 (includes corresponding Graph/Chart) III-30

Table 39: Rest of Europe Historic Review for Gene
Amplification Technologies by Segment - Polymerase Chain
Reaction (PCR) and Other Gene Amplification Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2003 through 2008 (includes corresponding
Graph/Chart) III-31

Table 40: Rest of Europe 15-Year Perspective for Gene
Amplification Technologies by Segment - Percentage Breakdown
of Dollar Sales for Polymerase Chain Reaction (PCR) and
Other Gene Amplification Markets for Years 2003, 2011 and 2017 III-32

5. REST OF WORLD III-33
Market Analysis III-33
Table 41: Rest of World Market for Gene Amplification
Technologies - Recent Past, Current and Future Market Analysis
by Segment for Polymerase Chain Reaction (PCR) and Other
Gene Amplification Markets Independently Analyzed with
Annual Sales Figures in US$ Million for Years 2009 through
2017 (includes corresponding Graph/Chart) III-33

Table 42: Rest of World Historic Review for Gene
Amplification Technologies by Segment - Polymerase Chain
Reaction (PCR) and Other Gene Amplification Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2003 through 2008 (includes corresponding
Graph/Chart) III-34

Table 43: Rest of World 15-Year Perspective for Gene
Amplification Technologies by Segment - Percentage Breakdown
of Dollar Sales for Polymerase Chain Reaction (PCR) and
Other Gene Amplification Markets for Years 2003, 2011 and 2017
(includes corresponding Graph/Chart) III-35


IV. COMPETITIVE LANDSCAPE


Total Companies Profiled: 90 (including Divisions/Subsidiaries - 104)

------------------------------------------
Region/Country Players
------------------------------------------
The United States 60
Canada 4
Japan 4
Europe 34
France 4
Germany 5
The United Kingdom 15
Italy 1
Spain 2
Rest of Europe 7
Asia-Pacific (Excluding Japan) 2
------------------------------------------


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