Biologic Imaging Reagents: Technologies and Global Markets

Biologic Imaging Reagents: Technologies and Global Markets

INTRODUCTION

STUDY GOALS AND OBJECTIVES

BCC’s goal for this study is to determine the global market and future demand growth for biologic imaging reagents over a five-year period from 2008 to 2013. Our particular interest is to characterize and quantify the biologic imaging reagents market potential by technology, reagent type and end user market. We also evaluate future growth opportunities in emerging biologic imaging reagents such as quantum dots, nanoparticles, fluorescent proteins and supermolecules.

Imaging reagent types covered include fluorescent probes and dyes; fluorescent proteins; nanoparticles; fullerene and dendrimer supermolecules; magnetic resonance imaging; ultrasound and x-ray contrast reagents; and imaging radiopharmaceuticals.

Our key objective is to present a comprehensive discussion of where the state-of-the-art is in biologic imaging reagents and forecast the future commercial potential for the key market segments. This discussion will provide a basis for companies to make strategic choices about developing new products and markets, or employing biologic imaging reagents. The study will benefit reagent and instrument manufacturers; users of biologic imaging reagents; medical instrument companies; life sciences tools companies; diagnostic and drug manufacturers; biotechnology companies; and developers of nanotechnologies.

REASONS FOR DOING THE STUDY

Biologic imaging reagents play an important role in the medical, pharmaceutical, diagnostic, biotechnology and life sciences tools industries. Imaging and detection technologies are used extensively in medicine, biotechnology and pharmaceutical research. Traditional imaging techniques, such as x-ray, computer tomography (CT), ultrasound (US), magnetic resonance imaging (MRI) and nuclear medicine (NM), mainly analyze anatomy and morphology and cannot detect changes at the molecular level. However, new developments in biotechnology allow us to image at the cellular and molecular level, paving the way for earlier diagnosis and treatment of disease. Biologic imaging reagents play a critical role in this medical revolution.

At the same time, tremendous advances in genomics, proteomics and cellular analysis are assisted by imaging technologies including fluorescent dyes and probes, quantum dot nanoparticles, and fluorescent proteins. Growth in technologies such as biochips, DNA sequencing, and PCR relies on sensitive biologic fluorescent imaging reagents.

Advances in technologies that are used in biologic imaging reagents are also moving forward at a rapid pace. These technologies include nanotechnology, biologic targeting, microfluidics, supramolecular chemistry and protein engineering. Rapid developments across a number of technology fields promise to change the biologic imaging industry by enabling novel imaging reagents and unique market opportunities. This report analyzes these developments and their impact on the future markets for biologic imaging reagents.

Given these market and technology dynamics, it is especially timely to examine the biologic imaging reagents market.

INTENDED AUDIENCE

We have compiled a study of existing and future imaging reagent technologies that will be commercially important in the major end user segments including life science research tools, drug discovery and development, and diagnostics.

We present the various imaging reagent technologies, including fluorescent probes and dyes; nanomaterials; fluorescent proteins; supermolecules; contrast reagents, and imaging radiopharmaceuticals. We also examine the industry growth driving forces; product types; market applications; companies and industry alliances and acquisitions; future market potential and product sales forecasts for the period 2008 through 2013. We project the future use of biologic imaging reagents in the main end user segments and by technology.

This study will be of particular interest to life science research tools suppliers, pharmaceutical manufacturers, diagnostics, biotechnology, genomics, proteomics, nanotechnology and supramolecular companies. It will also be of interest to companies making products for medical imaging, microarrays, lab on a chip, polymerase chain reaction (PCR), molecular diagnostics assays, fluorescence in-situ hybridization (FISH), fluorescence activated cell sorting (FACS) as well as medical researchers and clinicians.  
 

CHAPTER ONE: INTRODUCTION

STUDY GOALS AND OBJECTIVES

REASONS FOR DOING THE STUDY

INTENDED AUDIENCE

SCOPE OF REPORT

METHODOLOGY

INFORMATION SOURCES

RELATED BCC REPORTS

ANALYST CREDENTIALS

BCC RESEARCH ONLINE SERVICES

DISCLAIMER

CHAPTER TWO: SUMMARY

SUMMARY TABLE GLOBAL VALUE OF BIOLOGIC IMAGING REAGENTS, BY TYPE, THROUGH 2013 ($ MILLIONS)

SUMMARY FIGURE GLOBAL VALUE OF BIOLOGIC IMAGING REAGENTS, BY TYPE, 2006-2013 ($ MILLIONS)

SUMMARY (CONTINUED)

CHAPTER THREE: OVERVIEW

INTRODUCTION

BIOLOGIC IMAGING TECHNOLOGIES COVERED IN THIS REPORT

TABLE 1 SCOPE OF THIS REPORT

MARKET POTENTIAL OF BIOLOGIC REAGENTS PRODUCTS

TABLE 2 GLOBAL VALUE OF BIOLOGIC IMAGING REAGENTS, BY TECHNOLOGY, THROUGH 2013 ($ MILLIONS)

TABLE 3 GLOBAL VALUE OF BIOLOGIC IMAGING REAGENTS, BY END USER MARKET, THROUGH 2013 ($ MILLIONS)

FORCES DRIVING BIOLOGIC IMAGING REAGENTS INDUSTRY GROWTH

TABLE 4 BIOLOGIC IMAGING REAGENTS GROWTH DRIVING FORCES

FORCES DRIVING BIOLOGIC … (CONTINUED)

LIFE CYCLE STATUS OF BIOLOGIC IMAGING REAGENTS TECHNOLOGIES

TABLE 5 LIFE CYCLE STAGE OF BIOLOGIC IMAGING REAGENTS

THE BIOLOGIC IMAGING REAGENTS INDUSTRY

TABLE 6 BIOLOGIC IMAGING REAGENTS KEY COMPETITORS

THE BIOLOGIC IMAGING REAGENTS … (CONTINUED)

CHAPTER FOUR: BIOLOGIC IMAGING TECHNOLOGIES

IMAGING REAGENT TYPES

TABLE 7 KEY BIOLOGIC IMAGING REAGENT TYPES

IN-VIVO IMAGING MODALITIES

TABLE 8 IN-VIVO IMAGING MODALITIES

TABLE 9 COMPARISON OF IN-VIVO IMAGING MODALITIES

IN-VIVO IMAGING MODALITIES (CONTINUED)

MOLECULAR IMAGING

IN-VITRO IMAGING/DETECTION

TABLE 10 APPLICATIONS OF IN-VITRO BIOLOGIC IMAGING

TRENDS IN IN-VIVO IMAGING

TABLE 11 KEY TRENDS FOR IN-VIVO IMAGING

TRENDS IN IN-VIVO IMAGING (CONTINUED)

BIOLOGIC IMAGING REAGENTS TECHNOLOGIES

NANOPARTICLES

TABLE 12 NANOPARTICLES IN IMAGING APPLICATIONS

Nanoparticles (Continued)

TABLE 13 COMPARISON OF ANTIBODY CONJUGATE NANOPARTICLES

FLUORESCENT DYES AND PROBES

TABLE 14 FLUORESCENT DYES AND PROBES

Fluorescent Dyes and Probes (Continued)

TABLE 15 ADVANTAGES OF FLUORESCENCE VERSUS TRADITIONAL METHODS

TABLE 16 FLUORESCENT DYE PERFORMANCE CRITERIA

FLUORESCENT PROTEINS

TABLE 17 TYPES OF FLUORESCENT PROTEINS

Fluorescent Proteins (Continued)

Genetically Engineering Fluorescent Proteins

TABLE 18 PHOTOACTIVABLE AND PHOTOCONVERTIBLE FLUORESCENT PROTEIN TYPES

Engineered Fluorescent Cell Lines

Emerging Fluorescent Protein Applications

TABLE 19 EMERGING APPLICATIONS OF FLUORESCENT PROTEINS

Comparison of Fluorescent Proteins with Fluorescent

Dyes

TABLE 20 FLUORESCENT PROTEINS VERSUS DYES

Technology Challenges

TABLE 21 TECHNOLOGY CHALLENGES FOR FLUORESCENT PROTEINS

SUPERMOLECULES

TABLE 22 CLASSIFICATION OF IMAGING SUPERMOLECULES

SUPERMOLECULES (Continued)

FIGURE 1 MOLECULAR ENGINEERING OF DENDRIMER IMAGING SUPERMOLECULES

QUANTUM DOTS

TABLE 23 COMPARISON OF QUANTUM DOTS, FLUORESCENT DYES AND FLUORESCENT PROTEINS

FIGURE 2 QUANTUM DOT SPECTRA

FIGURE 3 FLUORESCENT DYE SPECTRA

Quantum Dots (Continued)

TABLE 24 BIOLOGIC IMAGING APPLICATIONS OF QUANTUM DOTS

RADIOPHARMACEUTICALS

CONTRAST REAGENTS

Contrast Reagents (Continued)

Contrast Reagents (Continued)

EMERGING CLASSES OF IMAGING REAGENTS

COMPONENTS OF ADVANCED IMAGING REAGENT TECHNOLOGY

FIGURE 4 THREE COMPONENTS OF ADVANCED IMAGING REAGENT TECHNOLOGY

ADVANCED IMAGING REAGENT FUNCTIONS

TABLE 25 EMERGING ADVANCED BIOLOGIC IMAGING REAGENT FUNCTIONS

Dual Modality Reagents

Multifunctional Reagents

Multifunctional Reagents (Continued)

Multiplexed Reagents

BIOLOGIC IMAGING REAGENTS MANUFACTURING COSTS

FIGURE 5 MANUFACTURING COSTS OF IMAGING REAGENT CLASSES

BIOLOGIC IMAGING REAGENTS … (CONTINUED)

COMPARISON OF IMAGING REAGENT TECHNOLOGY PLATFORMS

TABLE 26 LIFE CYCLE OF BIOLOGIC IMAGING REAGENT TECHNOLOGIES

TABLE 27 TECHNOLOGY STATUS OF BIOLOGIC IMAGING REAGENT PLATFORMS

TABLE 28 TECHNOLOGY CHALLENGES FOR IN-VIVO IMAGING REAGENTS

COMPARISON OF IMAGING … (CONTINUED)

CHAPTER 5: BIOLOGIC IMAGING REAGENTS APPLICATIONS

OVERVIEW

TABLE 29 BIOLOGIC IMAGING REAGENTS APPLICATIONS

TABLE 30 SIGNIFICANCE OF BIOLOGIC IMAGING REAGENTS TO LIFE SCIENCES AND MEDICAL INDUSTRIES

TABLE 31 USE OF BIOLOGIC IMAGING REAGENTS BY MARKET SEGMENT

TABLE 31 (CONTINUED)

TABLE 32 APPLICATIONS WITHIN MARKET SEGMENTS

RESEARCH AND DEVELOPMENT

TABLE 33 R&D TOOLS

TABLE 34 EMERGING APPLICATIONS FOR BIOLOGIC IMAGING REAGENTS IN R&D TOOLS

DRUG DISCOVERY AND DEVELOPMENT

TABLE 35 DRUG DISCOVERY & DEVELOPMENT

INFLUENCE OF IMAGING TECHNOLOGY ON DRUG DEVELOPMENT

ATTRITION RATE OF LEAD COMPOUNDS

FIGURE 6 ATTRITION RATE OF DRUG CANDIDATES DURING DRUG DEVELOPMENT

FLUORESCENT PROTEIN APPLICATIONS IN DRUG DISCOVERY

IN-VIVO SMALL ANIMAL IMAGING APPLICATIONS

TABLE 36 COMPARISON OF SMALL ANIMAL IMAGING MODALITIES

TABLE 37 OUTSTANDING MARKET NEEDS FOR SMALL ANIMAL IMAGING

MICRODOSING

Biomarkers for Microdosing

TABLE 38 BIOMARKERS FOR MICRODOSING

Regulatory Requirements for Microdosing

Imaging Modalities for Microdosing

TABLE 39 MICRODOSING IMAGING MODALITIES

Status of Microdosing

DIAGNOSTICS

INTRODUCTION

TABLE 40 DIAGNOSTICS IMAGING REAGENTS APPLICATIONS

TABLE 40 (CONTINUED)

DIAGNOSTIC APPLICATIONS OF IMAGING REAGENTS

TABLE 41 DIAGNOSTIC APPLICATIONS OF SELECTED IMAGING REAGENTS

Fluorescent Dyes, Probes and Tags

Nanoparticles

Supermolecules

Imaging Radiopharmaceuticals

Contrast Reagents

MOLECULAR IMAGING

Introduction

TABLE 42 CLINICAL APPLICATIONS FOR IN VIVO MOLECULAR IMAGING

Optical Molecular Imaging Reagents Status

TABLE 43 FLUORESCENCE IMAGING REAGENTS PIPELINE STATUS

PET/SPECT Molecular Imaging Reagents Status

TABLE 44 PET/SPECT IMAGING REAGENTS PIPELINE STATUS

TABLE 44 (CONTINUED)

PET/SPECT …(Continued)

Biological Processes Associated with Molecular PET Imaging Reagents

TABLE 45 PET IMAGING REAGENT APPLICATIONS

Biological Processes … (Continued)

CASE STUDY: ALZHEIMER’S DISEASE IMAGING REAGENT OPPORTUNITIES

FIGURE 7 ALZHEIMER’S DISEASE’S PATHOLOGY PROGRESSION

MR IMAGING REAGENTS

TABLE 46 EXISTING AND EMERGING MRI IMAGING REAGENTS STATUS

TABLE 46 (CONTINUED)

ULTRASOUND IMAGING REAGENTS

NANOPARTICLES IN DIAGNOSTICS

TABLE 47 NANOPARTICLE IN-VIVO DIAGNOSTICS PIPELINE

TABLE 48 NANOSPHERE IN-VITRO DIAGNOSTICS REAGENTS PIPELINE

HYBRID DIAGNOSTIC/THERAPEUTIC APPLICATIONS

TABLE 49 HYBRID IMAGING/THERAPEUTIC APPLICATIONS

Hybrid Diagnostic/… (Continued)

CHAPTER SIX: BIOLOGIC IMAGING REAGENTS INDUSTRY STRUCTURE

MEDICAL IMAGING INSTRUMENT INDUSTRY

TABLE 50 COMPETITIVE FOCUS OF MAJOR MEDICAL IMAGING COMPANIES

INNOVATION WITHIN THE IMAGING REAGENT INDUSTRY

ROLE OF CORE IMAGING FACILITIES

ROLE OF STRATEGIC ALLIANCES

TABLE 51 RECENT IMAGING REAGENT STRATEGIC ALLIANCES

TABLE 51 (CONTINUED)

TABLE 51 (CONTINUED)

Role of Strategic Alliances (Continued)

TABLE 52 BIOLOGIC IMAGING REAGENTS INDUSTRY ACQUISITIONS, 2005-2008

TABLE 52 (CONTINUED)

TABLE 52 (CONTINUED)

TABLE 52 (CONTINUED)

2005

2006

2006 (Continued)

2007

2008

SPECIALIZED INDUSTRY SECTORS

FLUORESCENT DYES AND PROBES

TABLE 53 FLUORESCENT DYES AND PROBES KEY COMPETITORS

QUANTUM DOTS

TABLE 54 QUANTUM DOTS KEY COMPETITORS

TABLE 54 (CONTINUED)

CONTRAST REAGENTS

TABLE 55 CONTRAST REAGENTS KEY COMPETITORS

RADIOPHARMACEUTICALS

TABLE 56 RADIOPHARMACEUTICALS BIOTECHNOLOGY COMPANIES

Radioactive Isotope Supply Industry

SMALL ANIMAL IN-VIVO IMAGING

TABLE 57 SMALL ANIMAL IN-VIVO FUNCTIONAL IMAGING COMPETITORS

CARDIAC IMAGING

TABLE 58 CARDIAC IMAGING REAGENT COMPETITIVE SPACE

FLUORESCENT PROTEINS

TABLE 59 FLUORESCENT PROTEIN PRODUCERS

ANTIBODY BIOTECHNOLOGY COMPANIES

TABLE 60 ANTIBODY BIOTECHNOLOGY COMPANIES WHO HAVE INTEREST IN IMAGING REAGENTS

CHAPTER SEVEN: BIOLOGIC IMAGING REAGENTS MARKETS

GROWTH DRIVING FORCES

TABLE 61 BIOLOGIC IMAGING REAGENTS GROWTH DRIVING FORCES

GROWTH DRIVING FORCES (CONTINUED)

RADIOPHARMACEUTICALS

TABLE 77 GLOBAL VALUE OF RADIOPHARMACEUTICALS IMAGING REAGENTS MARKET, BY INDICATION, THROUGH 2013 ($ MILLIONS)

TABLE 78 GLOBAL VALUE OF ONCOLOGY RADIOPHARMACEUTICALS IMAGING REAGENTS MARKET, BY INDICATION, THROUGH 2013 ($ MILLIONS)

TABLE 79 GLOBAL VALUE OF ONCOLOGY RADIOPHARMACEUTICALS IMAGING REAGENTS MARKET, BY PRODUCT, THROUGH 2013 ($ MILLIONS)

TABLE 80 GLOBAL VALUE OF FDG RADIOPHARMACEUTICAL REAGENTS, BY DISEASE CLASS, THROUGH 2013 ($ MILLIONS)

OPTICAL IMAGING REAGENTS

TABLE 81 GLOBAL VALUE OF OPTICAL FLUORESCENT IMAGING REAGENTS MARKET, BY APPLICATION, THROUGH 2013 ($ MILLIONS)

TABLE 82 GLOBAL VALUE OF IN-VITRO RESEARCH AND DRUG DISCOVERY AND DEVELOPMENT OPTICAL FLUORESCENT IMAGING REAGENTS MARKET, BY ASSAY, THROUGH 2013 ($ MILLIONS)

TABLE 83 GLOBAL VALUE OF GENOMICS IN-VITRO OPTICAL FLUORESCENT IMAGING REAGENTS MARKET, BY ASSAY TYPE, THROUGH 2013 ($ MILLIONS)

TABLE 84 GLOBAL VALUE OF PROTEOMICS IN-VITRO OPTICAL FLUORESCENT IMAGING REAGENTS MARKET, BY ASSAY TYPE, THROUGH 2013 ($ MILLIONS)

TABLE 85 GLOBAL VALUE OF CELLULAR ANALYSIS IN-VITRO OPTICAL FLUORESCENT IMAGING REAGENTS MARKET, BY ASSAY TYPE, THROUGH 2013 ($ MILLIONS)

TABLE 86 GLOBAL VALUE OF OPTICAL FLUORESCENT IMAGING REAGENTS, BY END USE, THROUGH 2013 ($ MILLIONS)

OPTICAL IMAGING REAGENTS (Continued)

TABLE 87 GLOBAL VALUE OF IN-VITRO DIAGNOSTIC FLUORESCENT OPTICAL IMAGING REAGENTS, BY MARKET SEGMENT, THROUGH 2013 ($ MILLIONS)

TABLE 88 GLOBAL VALUE OF OPTICAL IMAGING REAGENTS, BY TYPE, THROUGH 2013 ($ MILLIONS)

GEOGRAPHICAL

TABLE 89 GLOBAL VALUE OF BIOLOGIC IMAGING REAGENTS, BY GEOGRAPHY, THROUGH 2013 ($ MILLIONS)

Geographical (Continued)

CHAPTER EIGHT: PATENT STATUS

IMAGING REAGENTS PATENTS BY SELECTED TECHNOLOGY

TABLE 90 NUMBER OF PATENTS BY TECHNOLOGY

FLUORESCENCE REAGENTS

TABLE 91 FLUORESCENCE REAGENTS PATENT ASSIGNEES BY COMPANY (NUMBER OF PATENTS)

FLUORESCENT PROTEINS

TABLE 92 FLUORESCENT PROTEIN PATENT ASSIGNEES BY COMPANY (NUMBER OF PATENTS)

DENDRIMERS

TABLE 93 DENDRIMER PATENT ASSIGNEES BY COMPANY (NUMBER OF PATENTS)

TABLE 94 QUANTUM DOTS PATENT ASSIGNEES BY COMPANY (NUMBER OF PATENTS)

PATENTS BY COMPANY

FIGURE 8 PATENTS BY COMPANY FOR MARKET SEGMENTS

LITIGATION STATUS

TABLE 95 IP LITIGATION STATUS

CHAPTER NINE: COMPANY PROFILES

ACUSPHERE, INC.

TABLE 96 ACUSPHERE PRODUCT PIPELINE

TABLE 97 ACUSPHERE PATENT ESTATE

TABLE 97 (CONTINUED)

ADVANCED RESEARCH TECHNOLOGIES INC.

AFFIBODY AB

AION DIAGNOSTICS

ALNIS BIOSCIENCES INC.

ALSERES PHARMACEUTICALS INC.

AMAG PHARMACEUTICALS

TABLE 98 AMAG MOLECULAR IMAGING REAGENTS PIPELINE

TABLE 99 AMAG MRI IMAGING REAGENTS MARKETING ALLIANCES

ANTICANCER INC

AVID RADIOPHARMACEUTICALS

TABLE 100 AVID DIAGNOSTIC IMAGING PIPELINE

BAYER SCHERING PHARMA AG

BBI INTERNATIONAL

BD BIOSCIENCES

BECKMAN COULTER, INC.

BIOFORCE NANOSCIENCES HOLDINGS, INC.

BIOMODA INC.

BIOPHAN TECHNOLOGIES, INC

BIOSEARCH TECHNOLOGIES, INC.

BIOSCEPTRE

BIOTAGE AB

BRACCO DIAGNOSTICS INC

CALIPER LIFE SCIENCES, INC.

CAMBRIDGE ISOTOPE LABORATORIES, INC.

CAPSULUTION NANOSCIENCES AG

CARDINAL HEALTH

CARESTREAM HEALTH, INC

CELLCYTE GENETICS

CHEMICELL GMBH

CHINA MEDICAL TECHNOLOGIES, INC.

COVIDIEN

DENDRITECH, INC.

DO-COOP TECHNOLOGIES

EBIOSCIENCE, INC.

EPIX PHARMACEUTICALS

EPIX Pharmaceuticals (Continued)

EVIDENT TECHNOLOGIES

EVROGEN

FERROPHARM GMBH

FLUOROPHARMA

TABLE 101 FLUORPHARMA PET IMAGING REAGENT PIPELINE

FLUOROTECHNICS PTY LTD.

Fluorotechnics Pty Ltd. (Continued)

GE HEALTHCARE

TABLE 102 GE HEALTHCARE IMAGING REAGENTS PIPELINE

GUERBET

IBA MOLECULAR

IMMUNICON

INDEC BIOSYSTEMS

INVITROGEN

Invitrogen (Continued)

JUBILANT ORGANOSYS LTD

TABLE 103 JUBILANT ORGANOSYS MEDICAL IMAGING REAGENT PIPELINE

Jubilant Organosys Ltd. (Continued)

KEREOS, INC.

TABLE 104 KEREOS IMAGING REAGENTS PIPELINE

TABLE 105 KEREOS STRATEGIC ALLIANCES

KPL, INC.

LANTHEUS MEDICAL IMAGING

TABLE 106 LANTHEUS DIAGNOSTIC IMAGING PIPELINE

LUNA NANOWORKS

MARINPHARM GMBH

MBL INTERNATIONAL

MOLECULAR INSIGHT PHARMACEUTICALS

MOLECULAR TARGETING TECHNOLOGIES, INC

TABLE 107 MTTI IMAGING REAGENTS PIPELINE

NANOCO TECHNOLOGIES LTD.

NANOPROBES, INC.

NANOSPECTRA BIOSCIENCES

NANOSPHERE, INC.

TABLE 108 NANOSPHERE GOLD IMAGING REAGENTS PIPELINE

OXONICA INC.

PHILIPS HEALTHCARE

PROMEGA CORPORATION

SELAH TECHNOLOGIES, LLC

SIEMENS AG

Siemens AG (Continued)

SIGNALOMICS GMBH

STARPHARMA HOLDINGS LTD

Starpharma Holdings Ltd. (Continued)

TAKARA BIO INC.

THERMO FISHER SCIENTIFIC

TK SIGNAL

VISEN MEDICAL INC.

WILEX AG

TABLE 109 WILEX PRODUCT PIPELINE

LIST OF TABLES

SUMMARY TABLE GLOBAL VALUE OF BIOLOGIC IMAGING

REAGENTS, BY TYPE, THROUGH 2013 ($ MILLIONS)

TABLE 1 SCOPE OF THIS REPORT

TABLE 2 GLOBAL VALUE OF BIOLOGIC IMAGING REAGENTS, BY

TECHNOLOGY, THROUGH 2013 ($ MILLIONS)

TABLE 3 GLOBAL VALUE OF BIOLOGIC IMAGING REAGENTS, BY

END USER MARKET, THROUGH 2013 ($ MILLIONS)

TABLE 4 BIOLOGIC IMAGING REAGENTS GROWTH DRIVING FORCES

TABLE 5 LIFE CYCLE STAGE OF BIOLOGIC IMAGING REAGENTS

TABLE 6 BIOLOGIC IMAGING REAGENTS KEY COMPETITORS

TABLE 7 KEY BIOLOGIC IMAGING REAGENT TYPES

TABLE 8 IN-VIVO IMAGING MODALITIES

TABLE 9 COMPARISON OF IN-VIVO IMAGING MODALITIES

TABLE 10 APPLICATIONS OF IN-VITRO BIOLOGIC IMAGING

TABLE 11 KEY TRENDS FOR IN-VIVO IMAGING

TABLE 12 NANOPARTICLES IN IMAGING APPLICATIONS

TABLE 13 COMPARISON OF ANTIBODY CONJUGATE

NANOPARTICLES

TABLE 14 FLUORESCENT DYES AND PROBES

TABLE 15 ADVANTAGES OF FLUORESCENCE VERSUS TRADITIONAL

METHODS

TABLE 16 FLUORESCENT DYE PERFORMANCE CRITERIA

TABLE 17 TYPES OF FLUORESCENT PROTEINS

TABLE 18 PHOTOACTIVABLE AND PHOTOCONVERTIBLE

FLUORESCENT PROTEIN TYPES

TABLE 19 EMERGING APPLICATIONS OF FLUORESCENT PROTEINS

TABLE 20 FLUORESCENT PROTEINS VERSUS DYES

TABLE 21 TECHNOLOGY CHALLENGES FOR FLUORESCENT

PROTEINS

TABLE 22 CLASSIFICATION OF IMAGING SUPERMOLECULES

TABLE 23 COMPARISON OF QUANTUM DOTS, FLUORESCENT DYES

AND FLUORESCENT PROTEINS

TABLE 24 BIOLOGIC IMAGING APPLICATIONS OF QUANTUM DOTS

TABLE 25 EMERGING ADVANCED BIOLOGIC IMAGING REAGENT

FUNCTIONS

TABLE 26 LIFE CYCLE OF BIOLOGIC IMAGING REAGENT

TECHNOLOGIES

TABLE 27 TECHNOLOGY STATUS OF BIOLOGIC IMAGING REAGENT

PLATFORMS

TABLE 28 TECHNOLOGY CHALLENGES FOR IN-VIVO IMAGING

REAGENTS

TABLE 29 BIOLOGIC IMAGING REAGENTS APPLICATIONS

TABLE 30 SIGNIFICANCE OF BIOLOGIC IMAGING REAGENTS TO LIFE

SCIENCES AND MEDICAL INDUSTRIES

TABLE 31 USE OF BIOLOGIC IMAGING REAGENTS BY MARKET

SEGMENT

TABLE 32 APPLICATIONS WITHIN MARKET SEGMENTS

TABLE 33 R&D TOOLS

TABLE 34 EMERGING APPLICATIONS FOR BIOLOGIC IMAGING

REAGENTS IN R&D TOOLS

TABLE 35 DRUG DISCOVERY & DEVELOPMENT

TABLE 36 COMPARISON OF SMALL ANIMAL IMAGING MODALITIES

TABLE 37 OUTSTANDING MARKET NEEDS FOR SMALL ANIMAL

IMAGING

TABLE 38 BIOMARKERS FOR MICRODOSING

TABLE 39 MICRODOSING IMAGING MODALITIES

TABLE 40 DIAGNOSTICS IMAGING REAGENTS APPLICATIONS

TABLE 41 DIAGNOSTIC APPLICATIONS OF SELECTED

IMAGING REAGENTS

TABLE 42 CLINICAL APPLICATIONS FOR IN VIVO MOLECULAR

IMAGING

TABLE 43 FLUORESCENCE IMAGING REAGENTS PIPELINE STATUS

TABLE 44 PET/SPECT IMAGING REAGENTS PIPELINE STATUS

TABLE 45 PET IMAGING REAGENT APPLICATIONS

TABLE 46 EXISTING AND EMERGING MRI IMAGING REAGENTS

STATUS

TABLE 47 NANOPARTICLE IN-VIVO DIAGNOSTICS PIPELINE

TABLE 48 NANOSPHERE IN-VITRO DIAGNOSTICS REAGENTS

PIPELINE

TABLE 49 HYBRID IMAGING/THERAPEUTIC APPLICATIONS

TABLE 50 COMPETITIVE FOCUS OF MAJOR MEDICAL IMAGING

COMPANIES

TABLE 51 RECENT IMAGING REAGENT STRATEGIC ALLIANCES

TABLE 52 BIOLOGIC IMAGING REAGENTS INDUSTRY ACQUISITIONS,

2005-2008

TABLE 53 FLUORESCENT DYES AND PROBES KEY COMPETITORS

TABLE 54 QUANTUM DOTS KEY COMPETITORS

TABLE 55 CONTRAST REAGENTS KEY COMPETITORS

TABLE 56 RADIOPHARMACEUTICALS BIOTECHNOLOGY COMPANIES.... 113

TABLE 57 SMALL ANIMAL IN-VIVO FUNCTIONAL IMAGING

COMPETITORS

TABLE 58 CARDIAC IMAGING REAGENT COMPETITIVE SPACE

TABLE 59 FLUORESCENT PROTEIN PRODUCERS

TABLE 60 ANTIBODY BIOTECHNOLOGY COMPANIES WHO HAVE

INTEREST IN IMAGING REAGENTS

TABLE 61 BIOLOGIC IMAGING REAGENTS GROWTH DRIVING

FORCES

TABLE 62 GLOBAL VALUE OF INSTRUMENTS AND ASSAYS

UTILIZING BIOLOGIC IMAGING REAGENTS, THROUGH 2013

($ MILLIONS)

TABLE 63 GLOBAL VALUE OF BIOLOGIC IMAGING REAGENTS, BY

TECHNOLOGY, THROUGH 2013 ($ MILLIONS)

TABLE 64 GLOBAL VALUE OF BIOLOGIC IMAGING REAGENTS

MARKET, BY END USE, THROUGH 2013 ($ MILLIONS)

TABLE 65 GLOBAL VALUE OF BIOLOGIC REAGENTS MARKET, BY

FUNCTION, THROUGH 2013 ($ MILLIONS)

TABLE 66 GLOBAL VALUE OF BIOLOGIC IMAGING REAGENTS, BY

END USER MARKET, THROUGH 2013 ($ MILLIONS)

TABLE 67 GLOBAL VALUE OF BIOLOGIC REAGENTS MARKET, BY

MODALITY, THROUGH 2013 ($ MILLIONS)

TABLE 68 GLOBAL VALUE OF FLUORESCENT PROTEIN REAGENTS,

BY TYPE, THROUGH 2013 ($ MILLIONS)

TABLE 69 GLOBAL VALUE OF IMAGING NANOPARTICLES BY

TECHNOLOGY THROUGH 2013 ($ MILLIONS)

TABLE 70 GLOBAL VALUE OF CONTRAST AGENTS MARKET, BY

MODALITY, THROUGH 2013 ($ MILLIONS)

TABLE 71 GLOBAL VALUE OF MRI REAGENTS MARKET, BY TYPE,

THROUGH 2013 ($ MILLIONS)

TABLE 72 GLOBAL VALUE OF MRI GD CHELATE REAGENTS, BY

PRODUCT, THROUGH 2013 ($ MILLIONS)

TABLE 73 GLOBAL VALUE OF MRI NON-GD CHELATE REAGENTS, BY

PRODUCT, THROUGH 2013 ($ MILLIONS)

TABLE 74 GLOBAL SALES OF MRI CONTRAST REAGENTS, BY

PROCEDURE, THROUGH 2013 ($ MILLIONS)

TABLE 75 GLOBAL VALUE OF ULTRASOUND REAGENTS MARKET, BY

TYPE, THROUGH 2013 ($ MILLIONS)

TABLE 76 GLOBAL VALUE OF X-RAY/CT REAGENTS MARKET, BY

TYPE, THROUGH 2013 ($ MILLIONS)

TABLE 77 GLOBAL VALUE OF RADIOPHARMACEUTICALS IMAGING

REAGENTS MARKET, BY INDICATION, THROUGH 2013

($ MILLIONS)

TABLE 78 GLOBAL VALUE OF ONCOLOGY

RADIOPHARMACEUTICALS IMAGING REAGENTS MARKET, BY

INDICATION, THROUGH 2013 ($ MILLIONS)

TABLE 79 GLOBAL VALUE OF ONCOLOGY

RADIOPHARMACEUTICALS IMAGING REAGENTS MARKET, BY

PRODUCT, THROUGH 2013 ($ MILLIONS)

TABLE 80 GLOBAL VALUE OF FDG RADIOPHARMACEUTICAL

REAGENTS, BY DISEASE CLASS, THROUGH 2013 ($ MILLIONS)

TABLE 81 GLOBAL VALUE OF OPTICAL FLUORESCENT IMAGING

REAGENTS MARKET, BY APPLICATION, THROUGH 2013

($ MILLIONS)

TABLE 82 GLOBAL VALUE OF IN-VITRO RESEARCH AND DRUG

DISCOVERY AND DEVELOPMENT OPTICAL FLUORESCENT

IMAGING REAGENTS MARKET, BY ASSAY, THROUGH 2013

($ MILLIONS)

TABLE 83 GLOBAL VALUE OF GENOMICS IN-VITRO OPTICAL

FLUORESCENT IMAGING REAGENTS MARKET, BY ASSAY TYPE,

THROUGH 2013 ($ MILLIONS)

TABLE 84 GLOBAL VALUE OF PROTEOMICS IN-VITRO OPTICAL

FLUORESCENT IMAGING REAGENTS MARKET, BY ASSAY TYPE,

THROUGH 2013 ($ MILLIONS)

TABLE 85 GLOBAL VALUE OF CELLULAR ANALYSIS IN-VITRO

OPTICAL FLUORESCENT IMAGING REAGENTS MARKET, BY

ASSAY TYPE, THROUGH 2013 ($ MILLIONS)

TABLE 86 GLOBAL VALUE OF OPTICAL FLUORESCENT IMAGING

REAGENTS, BY END USE, THROUGH 2013 ($ MILLIONS)

TABLE 87 GLOBAL VALUE OF IN-VITRO DIAGNOSTIC FLUORESCENT

OPTICAL IMAGING REAGENTS, BY MARKET SEGMENT, THROUGH

2013 ($ MILLIONS)

TABLE 88 GLOBAL VALUE OF OPTICAL IMAGING REAGENTS, BY

TYPE, THROUGH 2013 ($ MILLIONS)

TABLE 89 GLOBAL VALUE OF BIOLOGIC IMAGING REAGENTS, BY

GEOGRAPHY, THROUGH 2013 ($ MILLIONS)

TABLE 90 NUMBER OF PATENTS BY TECHNOLOGY

TABLE 91 FLUORESCENCE REAGENTS PATENT ASSIGNEES BY

COMPANY (NUMBER OF PATENTS)

TABLE 92 FLUORESCENT PROTEIN PATENT ASSIGNEES BY

COMPANY (NUMBER OF PATENTS)

TABLE 93 DENDRIMER PATENT ASSIGNEES BY COMPANY (NUMBER

OF PATENTS)

TABLE 94 QUANTUM DOTS PATENT ASSIGNEES BY COMPANY

(NUMBER OF PATENTS)

TABLE 95 IP LITIGATION STATUS

TABLE 96 ACUSPHERE PRODUCT PIPELINE

TABLE 97 ACUSPHERE PATENT ESTATE

TABLE 98 AMAG MOLECULAR IMAGING REAGENTS PIPELINE

TABLE 99 AMAG MRI IMAGING REAGENTS MARKETING ALLIANCES

TABLE 100 AVID DIAGNOSTIC IMAGING PIPELINE

TABLE 101 FLUORPHARMA PET IMAGING REAGENT PIPELINE

TABLE 102 GE HEALTHCARE IMAGING REAGENTS PIPELINE

TABLE 103 JUBILANT ORGANOSYS MEDICAL IMAGING REAGENT

PIPELINE

TABLE 104 KEREOS IMAGING REAGENTS PIPELINE

TABLE 105 KEREOS STRATEGIC ALLIANCES

TABLE 106 LANTHEUS DIAGNOSTIC IMAGING PIPELINE

TABLE 107 MTTI IMAGING REAGENTS PIPELINE

TABLE 108 NANOSPHERE GOLD IMAGING REAGENTS PIPELINE

TABLE 109 WILEX PRODUCT PIPELINE

LIST OF FIGURES

SUMMARY FIGURE GLOBAL VALUE OF BIOLOGIC IMAGING

REAGENTS, BY TYPE, 2006-2013 ($ MILLIONS)

FIGURE 1 MOLECULAR ENGINEERING OF DENDRIMER IMAGING

SUPERMOLECULES

FIGURE 2 QUANTUM DOT SPECTRA

FIGURE 3 FLUORESCENT DYE SPECTRA

FIGURE 4 THREE COMPONENTS OF ADVANCED IMAGING REAGENT

TECHNOLOGY

FIGURE 5 MANUFACTURING COSTS OF IMAGING REAGENT

CLASSES

FIGURE 6 ATTRITION RATE OF DRUG CANDIDATES DURING DRUG

DEVELOPMENT

FIGURE 7 ALZHEIMER’S DISEASE’S PATHOLOGY PROGRESSION

FIGURE 8 PATENTS BY COMPANY FOR MARKET SEGMENTS