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Drug Solubility Technology: Spray Drying, Extrusion and SCF: Processes, Products, and Prospects

  • April 2013
  • Greystone Research Associates
Report ID: 1254451

Summary

Table of Contents

As drug suppliers re-examine their business models to adjust to the rapidly evolving competitive landscape, the importance and impact of drug solubility on drug design and development is increasing in importance, extending beyond potential future drug therapeutics, and affecting current reformulation strategies as well. As large-molecule therapeutics increase in number and as a percentage of all drug discoveries, the economic scales will tip in favor of those drug developers possessing the ability to engineer water-soluble formulations of inherently hydrophobic compounds. The importance of solubilization technologies is also underscored by the capability they bestow on formulators attempting to re-formulate approved drugs approaching the end of their patent life. The survey examines established physical processes for improving and enhancing drug solubility, including spray dry dispersion, hot melt extrusion and supercritical fluid processing.

Highlights

• Analyzes and evaluates drug formulation process technology improving the properties of insoluble poorly soluble and/or poorly absorbed drug candidates
• Examines evolving market factors
• Provides detailed assessments and status of commercial technologies designed to improve drug solubility
• Profiles drug solubility technology market participants, their research activity, proprietary technology, and business strategies

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