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Pharmaceutical Spray Drying Market, 2014-2024

  • June 2014
  • 146 pages
  • Roots Analysis Private Ltd.
Report ID: 2185204

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INTRODUCTION

The concept of ‘spray drying’ started in late 19th century in the food and chemical industry. Within pharmaceutical industry, spray drying found its use initially for the production of APIs. The technology has not been used as widely for commercial drug formulations yet. We have come across only limited examples of marketed drugs for which spray drying is used for developing the commercial batches. The future growth in the market will primarily be driven by aseptic spray drying, which allows production of biologics and vaccines. The process, being suitable for heat-sensitive products, is likely to find acceptance for drying of biologics. This will help eliminate the requirement for cold chains and refrigeration, saving not just the cost of maintaining such processes, but also prevent the costs associated with drug batches which lose integrity due to cold chain challenges.

Both freeze drying and spray drying methods are based on the concept of solvent evaporation. However, unlike freeze drying that only allows solvent evaporation, a major advantage of spray drying is that it helps manipulate the particle size of powdered drugs. It is an efficient, economical and a relatively more stable method of drying. The single step process of drying also helps improve the compression properties of drugs, allowing drug developers to reduce the number of pills or tablet size. This can help improve patient compliance or be used for life cycle management for drugs nearing patent expiry.

Big pharmaceutical companies, such as GSK and Janssen, have established in-house facilities for commercial production of their spray dried drugs. There is widespread optimism that the pharmaceutical spray drying market is likely to witness double digit growth in the future. Given that currently majority of the market is driven by lyophilization, it is highly likely that the growth in spray drying market is going to come from the pipeline of drugs rather than existing marketed drugs themselves. CMOs, specifically, are expected to play a leading role in the industry’s evolution; many have already invested in developing capabilities to meet the demand of clients.

SCOPE OF THE REPORT

The “Pharmaceutical Spray Drying Market, 2014-2024” report provides an extensive study on the emergence of spray drying in the pharmaceutical sector. The focus of this report is primarily to understand the likely future evolution of spray drying for manufacturing of Active Pharmaceutical Ingredients (APIs), inhalables, injectables, biologics and other affiliated products. When compared to conventional drying techniques, spray drying offers multiple advantages such as improved particle size distribution, improved solubility and bioavailability, enhanced taste and relatively more stable end products.

The report covers various aspects such as applications of spray drying, manufacturing / product landscape, CMOs active in spray drying, key growth drivers and the upcoming opportunities for various industry stakeholders. In fact, one of the key objectives of this report is to understand how popular is spray drying expected to become in the pharma industry over the course of next ten years. Based upon our research and discussions with industry stakeholders, we believe the technology will continue to strengthen its position in the pharma industry and gain a growing share of the market in the coming years. For the purposes of our analysis, we have looked at various scenarios that could unfold in the future; these scenarios represent different tracks of industry evolution and help us understand the potential of spray drying based upon wider developments across the industry.

The base year for the report is 2013. The report provides short-mid term and long term market forecasts for the period 2013 - 2018 and 2018 - 2024, respectively. The research, analysis and insights presented in this report include the growth of the overall pharma drying market distributed by spray drying, lyophilization and other drying technologies. The figures mentioned in this report are in USD, unless otherwise specified.

EXAMPLE HIGHLIGHTS

1. Spray drying has been used extensively for APIs in the pharmaceutical industry; however, there are only a few examples of spray dried commercial drugs. These include Intelence, Kalydeco, Incivek, and Zortress.
2. Specific to the pharmaceutical industry, there are around 50 models of spray dryers which are currently available worldwide. These models offer variation in the scale of operation (laboratory / pilot / industrial), evaporation rate, inlet air temperature and other technical parameters. The market is highly consolidated, with Niro and Buchi being the most preferred equipment providers.
3. CMOs have successfully identified the potential of this market, making requisite investments in the field to add spray drying to their portfolio or expand their capacities. We have identified around 40 contract manufacturers which are currently offering spray drying services for drugs and biologics.
4. Aseptic spray drying is likely to be one of the key focus areas in this sector. Not many companies are currently developing aseptic spray dryers or providing commercial aseptic spray drying services. The situation, though, is likely to change in the near-term.
5. Big pharma companies, such as, GSK, Janssen, Novartis have already invested in establishing in-house spray drying facilities. However, the existing installed capacity is likely to fall short of the growing demand in the future.
6. The overall pharma spray drying industry could grow beyond USD 1 billion in a few years’ time; this will be driven to a certain extent by the overall growth of the biopharmaceuticals’ market. Emergence of new technologies / applications is likely to provide the necessary impetus to fuel further growth.

RESEARCH METHODOLOGY

Most of the data presented in this report has been gathered via secondary and primary research. For all our projects, we conduct interviews with experts in the area (academia, industry, medical practice and other associations) to solicit their opinions on emerging trends in the market. This is primarily useful for us to draw out our own opinion on how the market will evolve across different regions and technology segments. Where possible, the available data has been checked for accuracy from multiple sources of information.

The secondary sources of information include
- Annual reports
- Investor presentations
- SEC filings
- Industry databases
- News releases from company websites
- Government policy documents
- Industry analysts’ views
While the focus has been on forecasting the market over the coming ten years, the report also provides our independent view on various technological and non-commercial trends emerging in the industry. This opinion is solely based on our knowledge, research and understanding of the relevant market gathered from various secondary and primary sources of information.

CHAPTER OUTLINES

Chapter 2 provides an executive summary of the insights captured in our research. The summary offers a high level view on where the pharmaceutical spray drying market is headed in the mid-long term.

Chapter 3 provides a general introduction to the spray drying. We have discussed, in detail the concepts behind spray drying and its applications and advantages.

Chapter 4 provides an overview of the spray drying market. The chapter offers details on the important parameters involved in spray drying (e.g., inlet air temperature, nozzle type, atomization gas used etc.). It also details the in house spray drying capabilities of top pharmaceutical companies.

Chapter 5 presents profiles of spray dryer manufacturers for pharmaceutical companies. Amongst other insights, the chapter discusses the technical details, financial information and relevant recent partnerships for respective companies.

Chapter 6 includes an analysis of the contract manufacture ring organizations (CMOs) active in the spray drying market. We have done a high level capacity, capability and regional analysis for CMOs. We have also profiled the top leading CMOs in this area providing details on their current product portfolio, recent collaborations and other relevant information.

Chapter 7 provides details of the applications of spray drying. Each application is supported by examples. The applications include the microencapsulation of the drug, taste masking, enhancing bioavailability and solubility.

Chapter 8 presents a scenario based approach to identify the future evolution of the pharma spray drying market. The forecast over the next ten year time period highlight the market’s overall potential and is based upon detailed insights gathered from discussions with industry stakeholders.
Chapter 9 is a case study on vaccines with a focus on the use of drying technology, including spray drying. We have studied the influenza vaccine to understand advantages of spray drying the vaccines.

Chapter 10 provides our analysis of the strengths, weaknesses, opportunities and threats in the spray drying market, capturing the key elements likely to influence future growth.

Chapter 11 is a compilation of interview transcripts; these discussions have helped us understand the key market dynamics, competitive landscape and the likely future trends in the industry.

Chapter 12 summarizes the overall report. In this chapter, we provide a recap of the key takeaways and our independent opinion based on the research and analysis described in previous chapters.

Chapters 13 and 14 are appendices, which provide the list of companies and tabulated data for all the figures presented in the report.

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