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Stem Cells -- 6 Dimensional Assessment (Technical Insights)

  • June 2014
  • 69 pages
  • Frost & Sullivan
Report ID: 2212032

Summary

Table of Contents

The clinical translation of regenerative cells

The scope of this research service comprises research within the area of adult and embryonic stem cells, and developments in the nascent area of induced pluripotent stem cells. While it will be next to impossible to capture all the developments in this area, this research service profiles some global developments in the area of stem cells. Popular technologies, path-breaking research, and excellent initiatives in the area of biomarker discovery and its applications from different parts of the world--including the United States, Canada, Germany, UK, Belgium, and Australia--have been covered.

Executive Summary
Distinguished from other cells by virtue of being unspecialized cells capable of renewing themselves through cell division, stem cells have demonstrated to have the potential to develop into many different cell types in the body during early life and growth. Indeed, under certain physiologic conditions they can be induced to become tissue or organ-specific cells with particular functions, thus serving as an internal repair system, dividing to replenish other cells. Stem cell therapeutics emerges as a new alternative to address most concern healthcare issues, especially for diseases that are currently inadequately treated or for which no therapeutic options exist. Remarkable, stem cells have the potential to cure diseases by stimulating the regeneration of healthy tissue in areas of damage. This fact represents an important advantage over pharmaceuticals, which typically treat the symptoms of a disorder. Beyond therapeutics, stem cells are becoming an extremely important tool for drug toxicity assays so that drug-safety issues can be detected in petri dishes before they get translated to patients. In fact, most commercialization strategies are focused on producing research tools for developing these cell lines. In order to provide valuable decision making tools, this research service aims to cover the principal aspects associated with the current situation of stem cells technologies, and its main trends and opportunities through a 6 dimensional analysis, around the Year of Impact:

1.IP Intensity
2.Funding
3.Market Potential
4.Megatrend Impact
5.Global Adoption Potential
6.Industry / Application Impact

Background
-Stem cells can continually self-regenerate and, under specific conditions, can differentiate into every cell type., thus offering unparalleled source of regenerative medicine technologies.
-In terms of pluripotency, embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) posses the greatest technological potential for applications in regenerative medicine, disease modeling, and developmental biology studies.
-Stem cell therapies are expected to be applicable to numerous diseases and conditions, even those currently considered non-curable, including a variety of genetic diseases, neurodegenerative disorders, different types of cancer, myelodysplasia, cardiovascular and autoimmune conditions, diabetes, renal failure, spinal repair, tissue regeneration or replacement, and complete organ reconstruction, among many others.
-As the population ages, the need for regenerative technologies, comprising stem cell technologies, increases dramatically. Similarly, the need for novel solutions to until today non-curable diseases is crucial.
-A number of stem cell-based technologies are being used today as bone marrow cells (BMCs) and some autologous stem cell therapies for treating hematological cancers, such as leukemia and other similar conditions.
-However, these only represent the edge of the iceberg constituting just a small fraction of the opportunities in stem cell technologies.
-The most promising field is related to iPSCs. Nevertheless, important research activity is still needed. Scientists are using genetics, genomics, proteomics, bioinformatics, cell culture, and engineering technologies to develop both a better understanding of the cell reprogramming.
-On the basis of some of the research findings, several companies are being established worldwide. In this report strengths, challenges, and opportunities in stem cell based medicine from both research and industry perspective are being addressed.

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