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PharmaPoint: Acute Coronary Syndrome - Global Drug Forecast and Market Analysis to 2025

PharmaPoint: Acute Coronary Syndrome - Global Drug Forecast and Market Analysis to 2025

  • August 2016
  • 416 pages
  • ID: 2466876
In this report:
NONETHELESS, THE ANTIHYPERTENSIVES STILL HELD ##% OF THE ENTIRE MARKET AND WILL SEE A NOTABLE INCREASE IN ITALIAN SALES FROM $##.##M IN 2015 TO $##.##M IN 2025, MIRRORING A CAGR OF ##.##%, WHICH IS ATTRIBUTED TO AN INCREASE IN DISEASE PREVALENCE.
AS WITH THE GLOBAL MARKET, ACS SALES IN FRANCE ARE EXPECTED TO INCREASE THROUGHOUT THE FORECAST PERIOD, RESULTING IN $##M IN SALES BY 2025, REFLECTING A CAGR OF ##.##%, WHICH SIMILARLY TRANSLATES TO ##% OF 2025 TOTAL GLOBAL SALES.

Summary

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PharmaPoint: Acute Coronary Syndrome - Global Drug Forecast and Market Analysis to 2025

Brief

Coronary artery disease, which precipitates acute coronary syndrome, is the most common type of cardiovascular disease in the seven main markets (7MM: US, France (FR), Germany (DE), Italy (IT), Spain (ES), UK, and Japan (JP)). At present, the cardiovascular drug market is well established and boasts a multitude of branded and generic drug choices to treat the main conditions combined with ACS: thrombosis (fibrinolytics, anticoagulants, and antiplatelets), hypercholesterolemia/atherosclerosis (statins and PCSK9 inhibitors), and hypertension inhibitors and beta blockers). Due to this range of sub-indications and the new increase in disease prevalence, it is evident that ACS represents a potentially lucrative market for Big Pharma to explore.

It is estimated that sales of acute coronary syndrome therapeutics to be approximately $7.8B across the 7MM in 2015, containing the U.S., the five main European markets (5EU: France (FR), Germany (DE), Italy (IT), Spain (ES), and UK), and Japan (JP). In the 2015 base year 10.0 percent of market share were attributed to the acute phase sales ($714M) and 90.0 percent to the chronic phase ($7.0B). By 2025, the ACS market to grow at a strong Compound Annual Growth Rate of 4.60 percent, reaching sales of $12.1B by the end of the forecast period. This is primarily attributed to the chronic phase growth, which is forecast to reflect a compound annual growth rate (CAGR) of 5.00 percent, reaching $11.4B in sales by 2025 (94.0 percent of market share).

As per Michela J. McMullan, Analyst: "At present, a big proportion of patients with clinical atherosclerotic cardiovascular disease cannot reach guideline recommended levels of LDL-C with the standard of care therapies, which leads to recurrent ACS events.

Major drivers of ACS market increase over the forecast period are the -

- Launches of the first PCSK9 inhibitors, Repatha and Praluent, in the U.S. (2015), EU (2015), and Japan (JP) (2016); and positive results from their cardiovascular outcomes trials.

- Launch of first-in-class lipid-lowering adenosine triphosphate-citrate lyase inhibitor/ adenosine monophosphate-activated protein kinase activator, ETC-1002, in 2021.

- Increase in the overall prevalence of ACS.

The analysis "PharmaPoint: Acute Coronary Syndrome - Global Drug Forecast and Market Analysis to 2025" offers overview of ACS, including epidemiology, etiology, pathophysiology, symptoms, diagnosis, and treatment guidelines.

Strategic analysis report:

- Annualized ACS therapeutics market revenue, annual cost of therapy and treatment usage pattern data from 2015 and estimate for ten years to 2025.

- Key topics covered include tactical competitor assessment, market characterization, unmet needs, clinical trial mapping and implications for the ACS therapeutics market.

- Pipeline analysis: exhaustive data split across various phases, emerging novel trends under development, and exhaustive analysis of late-stage pipeline drugs.

- Analysis of the current and future market competition in the overall ACS therapeutics market. Insightful review of the main industry drivers, restraints and challenges. Each trend is independently researched to provide qualitative analysis of its implications.

Corporations mentioned in this industry report: Amgen, AstraZeneca, Bristol-Myers Squibb, Cerenis Therapeutics, CSL Limited, Daiichi Sankyo, Eli Lilly, Esperion Therapeutics, GlaxoSmithKline, Janssen Pharmaceuticals,, The Medicines Company, Merck, Pfizer, Sanofi

Key Findings

Key questions & answers

- The additional generation antiplatelets, Brilinta and Effient will see a serious increase in patient shares for the treatment ACS against the previous cornerstone, clopidogrel. However, there are considerably high unmet needs within the indication. What are the principal unmet needs in this sector? Will the drugs under development fulfil the unmet needs of the ACS market?

- The PCSK9 inhibitors recently launched into the CV market, and these are predicted to have a notable impact in the ACS space once their CV outcomes data is shown. The most notable candidate in the current late-stage ACS pipeline is ETC-1002, which is vying to target the needed statin intolerant ACS population. Will these newly marketed and late-stage drugs make a meaningful impact on the ACS market? Which of these drugs will have the more significant peak sales at the more important Compound annual growth rate, and why?

- We have seen a notable increase in the ACS population in terms of diagnosed prevalent ACS cases , as well as ACS hospitalisations (incidence and recurrent events). How will epidemiological changes impact the growth of the future market?

Main highlights

- The principal driver of the serious expansion of the ACS market will be the increase in use and physician confidence in the PCSK9 inhibitor class, which will hold four main players by the end of this forecast. Novel lipid lowering therapy, ETC-1002, will also be a main contributor, vying to steal majority of patient shares for the statin intolerant ACS population by the end of this forecast.

- The main overall barrier for the ACS market will be the generic erosion of the top antiplatelet therapies, Brilinta and Effient by the end of this forecast. Both drugs will pick up meaningful momentum in sales prior to patent expiry.

- The dynamics of the ACS market will shift greatly towards solving the atherosclerotic burden associated in ACS from the historical strategy of developing antithrombotic therapies.

- The main market opportunities lie in addressing unmet needs through the development of optimal agents for secondary prevention by controlling lipid levels and repairing the damaged myocardium post myocardial infarction to prevent comorbidities including heart failure.

Overview

- Overview of ACS, including epidemiology, etiology, pathophysiology, symptoms, diagnosis, and treatment guidelines.

- Annualized ACS therapeutics market revenue, annual cost of therapy and treatment usage pattern data from 2015 and estimate for ten years to 2025.

- Key topics covered include tactical competitor assessment, market characterization, unmet needs, clinical trial mapping and implications for the ACS therapeutics market.

- Pipeline analysis: exhaustive data split across distinct phases, emerging novel trends under development, and in-depth analysis of late-stage pipeline drugs.

- Analysis of the current and future market competition in the overall ACS therapeutics market. Insightful review of the top industry drivers, restraints and challenges. Each trend is independently researched to provide qualitative analysis of its implications.

Great reasons to purchase

The market research will enable you to -

- Develop and design your in-licensing and out-licensing strategies through a review of pipeline products and technologies, and by identifying the companies with the most strong pipeline. Additionally a list of acquisition targets included in the pipeline product company list.

- Develop strategic management by understanding the trends shaping and driving the overall ACS therapeutics market.

- Drive revenues by understanding the main trends, innovative products and technologies, market segments, and firms likely to impact the overall ACS therapeutics market in future.

- Specified effective sales and marketing strategies by understanding the challenging landscape and by analysing the performance of different competitors.

- Identify emerging players with potentially strong product portfolios and create effective counter-strategies to gain a ambitious advantage.

- Track drug sales in the overall ACS therapeutics market from 2015-2025.

- Organize your sales and marketing efforts by identifying the market categories and segments that present maximum opportunities for consolidations, investments and tactical partnerships.

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