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Complete 2015-16 Induced Pluripotent Stem Cell Industry Report

  • April 2015
  • 175 pages
  • BioInformant Worldwide, L.L.C.
Report ID: 3321312

Summary

Table of Contents

Report Applications

This global strategic report is produced for:

Management of Stem Cell Product Companies
Management of Stem Cell Therapy Companies
Stem Cell Industry Investors
It is designed to increase your efficiency and effectiveness in:

Commercializing iPSC products, technologies, and therapies
Making intelligent investment decisions
Launching high-demand products
Selling effectively to your client base
Increasing revenue
Taking market share from your competition

Executive Summary

Stem cell research and experimentation have been in process for well over five decades, as stem cells have the unique ability to divide and replicate repeatedly In addition, their “unspecialized” nature allows them to differentiate into a wide variety of specialized cell types The possibilities arising from these characteristics have resulted in great commercial interest, with potential applications ranging from the use of stem cells in reversal and treatment of disease, to targeted cell therapy, tissue regeneration, pharmacological testing on cell-specific tissues, and more Conditions such as Huntington’s disease, Parkinson’s disease, and spinal cord injuries are examples of clinical applications in which stem cells could offer benefits in halting or even reversing damage

Traditionally, scientists have worked with both embryonic and adult stem cells for research tools, as well as for cellular therapy While the appeal of embryonic cells has been their ability to differentiate into any type of cell, there has been significant ethical, moral, and spiritual controversy surrounding their use Although some adult stem cells do have differentiation capacity, it is often limited in nature, which results in fewer options for use Thus, induced pluripotent stem cells represent a promising combination of adult and embryonic stem cell characteristics

Discovery of Induced Pluripotent Stem Cells

Groundbreaking experimentation in 2006 led to the introduction of induced pluripotent stem cells (iPSCs) These are adult cells which are isolated and then transformed into embryonic-like stem cells through the manipulation of gene expression, as well as other methods Research and experimentation using mouse cells by Shinya Yamanaka’s lab at Kyoto University in Japan was the first instance in which there was successful generation of iPSCs In 2007, a series of follow-up experiments was done at Kyoto University in which human adult cells were transformed into iPSCs Nearly simultaneously, a research group led by James Thomson at the University of Wisconsin-Madison accomplished the same feat of deriving iPSC lines from human somatic cells

Continued research and experimentation have resulted in numerous advances over the last few years For example, several independent research groups have announced that they have derived human cardiomyocytes from iPSCs These cells could be used in a laboratory context to test drugs that treat arrhythmia and other cardiac conditions, and in a clinical context they could potentially be implanted into patients with heart disorders

Similar advances will continue to be perfected for use of reprogrammed adult cells in the treatment of other diseases and disorders Original techniques for iPSC production, such as viral induced transcription processes, are being replaced with newer technologies as private industry joined with the scientific community to develop safer and more efficient methods of iPSC production As innovation around methods of iPSC production continues, clinical grade production of industrial quantities of iPSCs is now becoming possible due to sustained research and experimentation

Therapeutic Applications of Induced Pluripotent Stem Cells

While there has been continued excitement at the prospect of what such artificially re-manufactured cells could contribute to medical advances, there have also been setbacks along the way By 2010, there were a number of private companies that were ready to capitalize on the breakthrough technology that iPSCs represent One such company, Advanced Cell Technology (ACT) in Marlborough, Massachusetts, discovered several problematic issues while conducting experiments for the purpose of applying for US Food and Drug Administration approval to use iPSCs in therapeutic applications Concerns such as premature cell death, mutation into cancer cells, and low proliferation rates were some of the problems that surfaced

As a result, ACT (now named “Ocata Therapeutics”) has shifted its induced pluripotent stem cell approach to producing iPSC derived human platelets One of the benefits of a platelet-based product is that platelets do not contain nuclei, and therefore, cannot divide or carry genetic information While nothing is completely safe, iPSC derived platelets are likely to be substantially safer than other currently available iPSC therapies, in which uncontrolled proliferation may be a concern It also shifted to using embryonic stem cells for clinical trial purposes, despite the ethical concerns surrounding this cell type

Over the next few years, iPSC research advances accelerated exponentially, with perhaps the most momentous milestone being the launch of the first clinical research trial ever involving the transplant of autologous iPSCs into humans (“autologous” meaning the cells are both derived and implanted into the same patient) Previously, all clinical trials using iPSCs involved only the creation of iPSC lines from specific patient populations and subsequent evaluation of these lines for determining whether they could represent a good “model” for a disease of interest within that population

Therefore, 2013 was the first time in which clinical research involving transplant of iPSCs into humans was initiated, led by Masayo Takahashi of the RIKEN Center for Developmental Biology in Kobe, Japan Dr Takahashi and her team are investigating the safety of iPSC-derived cell sheets in patients with wet-type age-related macular degeneration While the trial was initiated in 2013 and production of iPSCs from patients began at that time, it was not until August of 2014 that the first patient, a Japanese woman, was implanted with retinal tissue generated using iPSCs derived from her own skin cells A team of three eye specialists, led by Yasuo Kurimoto of the Kobe City Medical Center General Hospital, implanted a 13 by 30mm sheet of iPSC-derived retinal pigment epithelium cells into the patient’s retina Preliminary results are indicating positive results for the participants in this iPSC clinical trial

Key Report Findings


Induced pluripotent stem cells represent one of the most promising research advances within the past decade, making this a valuable report for both executives and investors to use to optimally position themselves to sell iPSC products To profit from this lucrative and rapidly expanding market, you need to understand your key strengths relative to the competition, intelligently position your products to fill gaps in the market place, and take advantage of crucial iPSC trends

Key report findings include:

Metrics, Timelines, Tables, and Graphs for the iPSC Industry
Trend Rate Data for iPSC Grants, Clinical Trials, and Scientific Publications
Analysis of iPSC Patent Environment, including Key Patents and Patent Trends
Market Segmentation
5-Year Market Size Projections (2015-2019)
Market Size Estimations, by Market Segment
Updates on Crucial iPSC Industry and Technology Trends
Analysis of iPSC Market Leaders, by Market Segment
Geographical Assessment of iPSC Innovation
SWOT Analysis for the iPSC Sector (Strengths, Weaknesses, Opportunities, Threats)
Preferred Species for iPSC Research
Influential Language for Selling to iPSC Scientists
Breakdown of the Marketing Methods, including Exposure and Response Rates

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