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Opportunity Analyzer: Hodgkin’s Lymphoma (HL) - Opportunity Analysis and Forecasts to 2024

Opportunity Analyzer: Hodgkin’s Lymphoma (HL) - Opportunity Analysis and Forecasts to 2024

  • January 2016
  • 255 pages
  • ID: 3776354
In this report:
NET SALES OF ADCETRIS IN 2014 ACROSS THE US AND CANADA INCREASED ##% OVER 2013 TO $##M (SEATTLE GENETICS, 2015).
FURTHERMORE, INCYTE ANNOUNCED FIRST QUARTER NET PRODUCT REVENUE GROWTH IN 2015 FOR JAKAFI OF ##%, INCREASING TO $##M COMPARED TO $##M FOR THE SAME PERIOD IN 2014 (INCYTE, PRESS RELEASE, APRIL ##, 2015).

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Opportunity Analyzer: Hodgkin's Lymphoma - Opportunity Analysis and Estimations to 2024

Brief

Hodgkin's lymphoma, or Hodgkin's disease, is a malignancy which involves the lymph nodes and the lymphatic system. HL is a relatively rare type of cancer, accounting for 12.0 percent of all lymphomas and 0.60 percent of all additional cancer cases, but global prognosis is very good. However, treatment options for those patients who have failed first-line treatment are very few, and a serious unmet medical need remains in those patients. GlobalData estimated the HL market in the 7MM was valued at $316m in 2014. The HL market will increase approximately four-fold over the forecast period, reaching $1.40B by 2024 at a Compound annual growth rate of 16%. This growth will be driven by label extensions for Adcetris, which is poised to enter earlier lines of HL therapy, as well as the approval and uptake of premium-priced products, including the immune checkpoint inhibitors, Opdivo and Keytruda. By the end of the forecast period, GlobalData expects Adcetris to retain and extend its lead as the HL market front-runner, with Opdivo and Keytruda making up a meaningful amount of the market. GlobalData anticipates that pipeline agents will have to show an efficacy advantage over currently used and inexpensive standard of care therapies. The challenge for additional entrants in the HL market is to meet the high unmet need of relapsed or refractory HL patients, reduce the long-term toxic side effects of current treatments, and improve global survival.

Key Findings

Key questions & answers

- Over the final forty years, only one targeted therapy has been approved for the treatment of HL - Adcetris. The HL space is now filled with excitement because Adcetris label extensions and approval of the first anti-PD-1 therapies are anticipated to change the treatment landscape. What will be the impact of these newly approved drugs on HL sales?

- With the success of molecular-targeted therapies, containing immune checkpoint inhibitors, across the oncology therapy area, what R&D strategies are being leveraged by firms to remain ambitious in the HL space?

- The survival of R/R HL patients remains poor, especially for those who fail transplant therapies. Therefore, there are considerably high unmet needs within this indication. What are the principal unmet needs remaining in this space? Will the drugs under development fulfil the unmet needs of the HL market?

Main highlights

- One of the principal drivers in the expansion of the HL market will be the label extensions of Adcetris in earlier lines of HL therapy, which will include the post-transplantation consolidation setting, as well as newly diagnosed advanced stage patients. The premium-priced anti-PD1-therapies, Opdivo and Keytruda, will also launch and be used in the treatment of the R/R HL population. These drugs are poised to partially meet the remaining unmet medical need of these hard-to-treat patients.

- Another driver of market increase will be the few players in the HL space; therefore, there is ample room for additional market entrants. A main driver will also be an increase in HL incidence due to an increasing population. This will lead to an global increase of the number of drug-treatable HL patients, and market value.

- Corporations are focusing on the development of therapies targeting the R/R HL population, hoping to expedite the route to market for their pipeline products, and improving the integrated remission rate and duration of remission of these patients.

- One of the biggest unmet needs is that of the newly diagnosed advanced stage HL population. Other unmet needs contain the high proportion of patients failing transplant therapies and the toxicity of second-line treatment options.

Overview

- Overview of HL, including epidemiology, etiology, pathophysiology, symptoms, diagnosis, disease management, and current treatment options.

- Top-line HL therapeutics market revenue from 2014-2024. Average cost of therapy and main pipeline product sales in this forecast period are included.

- Key topics covered include tactical competitor assessment, market characterization, unmet needs, R&D strategies, and clinical trial design for the HL market.

- Pipeline analysis: exhaustive data split across distinct phases, emerging novel trends under development, synopses of innovative early-stage projects, and in-depth analysis of late-stage pipeline products. An interactive clinical and commercial analyzer tool is available.

- Analysis of the current and future market competition in the overall HL market. Insightful review of the top industry drivers, restraints and challenges. Each trend is independently researched to provide qualitative analysis of its implications.

Great reasons to purchase

The market research will enable you to -

- Develop and design your in-licensing and out-licensing strategies through a review of pipeline products and technologies, and by identifying the companies with the most strong pipeline.

- Develop strategic management by understanding the trends shaping and driving the overall HL market.

- Drive revenues by understanding the main trends, innovative products and technologies, market segments, and firms likely to impact the overall HL market in the outlook.

- Specified effective sales and marketing strategies by understanding the challenging landscape and by analysing the performance of different competitors.

- Identify emerging players with potentially strong product portfolios and create effective counter-strategies to gain a ambitious advantage.

- Organize your sales and marketing efforts by identifying the market categories and segments that present maximum opportunities for consolidations, investments and tactical partnerships.

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