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US Market for Peripheral Vascular Stents and Stent Grafts - MedCore

US Market for Peripheral Vascular Stents and Stent Grafts - MedCore

  • December 2015
  • 75 pages
  • ID: 3911676
  • Format: PDF
  • By iData Research, Inc.

Summary

Table of Contents

Stents are commonly used as complementary devices during conventional percutaneous transluminal angioplasty (PTA) balloon catheterization in peripheral vascular procedures. The placement of a stent mitigates some complications such as negative remodeling and elastic recoil effects. However, post-surgery complications such as restenosis occur in up to a half of patients who have undergone PTA. Abdominal aortic aneurysm (AAA) is the thirteenth-leading cause of death in the U.S. and a leading cause of death for American men over the age of 65. The most common location for aortic aneurysms is in the abdominal aorta. The rest occur in the thoracic area. As a result, most AAAs are located below the level of the renal arteries, and approximately 20 to 30% extend into one or both of the iliac arteries. Restenosis is a re-narrowing of the treated blood vessel and leads to decreased blood flow. It is commonly attributed to intimal hyperplasia at the site of the stenting procedure. For this reason, technological innovations, such as covered stents, which physically block cellular intrusion from neointimal hyperplasia (NIHA), have already become commercialized. Restenosis rates for PTA balloon catheters range from 10% to 12% in the iliac to 40% in the superficial femoral-popliteal arteries. Additionally, there is clinical evidence supporting the use of drug-eluting stents to combat these complications; however, incomplete endothelialization of the stent struts is leading to a reassessment of their efficacy. Abdominal aortic aneurysm (AAA) is the thirteenth-leading cause of death in the U.S. and a leading cause of death for American men over the age of 65. The most common location for aortic aneurysms is in the abdominal aorta. The rest occur in the thoracic area. As a result, most AAAs are located below the level of the renal arteries, and approximately 20 to 30% extend into one or both of the iliac arteries. Once an AAA develops, it begins to enlarge, increasing the likelihood of rupture. Left untreated, approximately one-third of AAAs will eventually rupture. When this occurs, internal bleeding causes most patients to die out of hospital or before surgery. Only 10% to 25% of patients who experience an AAA rupture survive to hospital discharge.

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