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Opportunity Analyzer: Huntington’s Disease - Opportunity Analysis and Forecast to 2024

Opportunity Analyzer: Huntington’s Disease - Opportunity Analysis and Forecast to 2024

  • May 2016
  • 250 pages
  • ID: 4042141
In this report:
Over the ##-year forecast period, the HD market is expected to grow at a compound annual growth rate (CAGR) of ##.##%, reaching approximately $##.## billion in 2024.
In 2024, RP## and PBT## are expected to generate sales of $##.##m and $##.##m, equating to ##.##% and ##.##% of the US HD market, respectively.
The sales of SD-## are expected to reach $##.##m in the US in 2024, representing ##.##% of the total US market by the end of the forecast period.


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Opportunity Analyzer: Huntington's Disease - Opportunity Analysis and Estimate to 2024


Huntington's Disease is a rare, autosomal-dominant, neurodegenerative disorder, characterized by impaired motor control, cognitive dysfunction, behavioral changes, and mood disorders. Approved treatments for HD across the 7MM are extremely limited, consisting of only two symptomatic treatments, tetrabenazine and tiapride, which are both approved for the treatment of HD-associated chorea. Other treatment options contributing to the HD market are off-label symptomatic drugs, various of which are widely genericized throughout the 7MM. Four late-stage pipeline drugs, two symptomatic treatments (SD-809 and pridopidine) and two thinkable DMDs (RP103 and PBT2) are anticipated to launch in the U.S. and 5EU markets during the forecast period, and will be a source of serious growth in the HD market. It is anticipated that SD-809 and pridopidine will also launch in Japan (JP) within the forecast period.

Key Findings

Key questions & answers

- The HD market has been dominated by tetrabenazine and tiapride (approved in Germany (DE), Italy (IT), and Spain (ES); off-label in France (FR) and Japan (JP)) for several years, with little approved therapeutic options available in the 7MM. New classes of drugs are anticipated to reach the industry within the forecast period. How will these change the market overall during the forecast period? Will tetrabenazine maintain market dominance in 2024?

- The current late stage HD pipeline is varied, with first-in-class drugs in development with innovative modes of action. Which of these will have the biggest impact on the sector? What strategies are developers undertaking to penetrate this chronically underserved market? Will these fulfil any unmet needs?

Main highlights

- The principal driver of growth in the HD market will be the introduction of premium-priced disease-modifying drugs and improved symptomatic therapies over the forecast period. The launch of these treatments will act as a stimulant for increase in this chronically underserved market.

- Significant barriers to growth in the HD market will be the high cost of novel treatments and plausible issues surrounding reimbursement, which will limit the use of more expensive drugs. Patients who have an acceptable level of symptomatic control with currently marketed drugs could result in limited treatment costs for HD.

- The arrival of additional therapies across the 7MM will increase treatment rates and provide alternative options for various patients.

- The biggest unmet needs in the HD market are the development of efficacious disease-modifying drugs and symptomatic treatments. Additionally, the identification of a strong HD biomarker for monitoring disease progression, as well as determining the effects of therapeutic interventions, is a meaningful unmet need in this field.


- Overview of HD, including epidemiology, etiology, pathophysiology, symptoms, diagnosis, and treatment guidelines.

- Annualized HD market revenue, annual cost of therapy and treatment usage pattern data from 2014 and estimate for ten years to 2024.

- Key topics covered include market characterization, unmet needs, R&D and clinical trials assessment, late stage clinical trial analysis and implications for the HD therapeutics market.

- Pipeline analysis: focus on the six late-stage pipeline HD drugs discussing emerging trends as well as overview of earlier phase drugs.

- Analysis of the current and future market competition in the overall HD therapeutics market. Insightful review of the top industry drivers, restraints and challenges. Each trend is independently researched to provide qualitative analysis of its implications.

Great reasons to purchase

The market research will enable you to -

- Develop and design your in-licensing and out-licensing strategies through a review of pipeline products and technologies, and by identifying the companies with the most strong pipeline. Additionally a list of acquisition targets included in the pipeline product company list.

- Develop strategic management by understanding the trends shaping and driving the overall HD therapeutics market.

- Drive revenues by understanding the main trends, innovative products and technologies, market segments, and firms likely to impact the overall HD therapeutics market in future.

- Specified effective sales and marketing strategies by understanding the challenging landscape and by analysing the performance of different competitors.

- Identify emerging players with potentially strong product portfolios and create effective counter-strategies to gain a ambitious advantage.

- Track drug sales in the overall HD therapeutics market from 2014-2024.

- Organize your sales and marketing efforts by identifying the market categories and segments that present maximum opportunities for consolidations, investments and tactical partnerships.

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