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Global Acne Market Report by Epidemiology, Region (US, EU5, Japan & India), Pipeline Analysis, Key players and Patent landscape for 2016-2026

Global Acne Market Report by Epidemiology, Region (US, EU5, Japan & India), Pipeline Analysis, Key players and Patent landscape for 2016-2026

  • November 2017
  • 111 pages
  • ID: 5246357
  • Format: PDF
  • EffeMarket


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Acne vulgaris, also known simply as acne, is a common, chronic, inflammatory disease of the glands that produce sebum (sebaceous follicles). This disease results in the formation of inflamed elevations (papules, pustules, nodules, and cysts), comedones (blackheads and whiteheads), and scars on the skin.

Acne is one of the most common disorders treated by dermatologists and other healthcare providers. More than 90 percent of world population is affected by acne at some point in their life. Although acne is a skin disease, it can lead to prominent emotional and psychological issues.

Several studies have confirmed that acne can affect a person’s quality of life, self-esteem, and mood in an adverse manner. Acne is a chronic, inflammatory skin condition with a multifactorial pathogenesis. The source is hormonal changes during puberty and it is then further exacerbated by genetic and other factors.

Apart from the classic belief that acne results from sebaceous gland hyperplasia, abnormal follicular differentiation with increased keratinization, microbial hyper-colonization of the follicular canal, and increased inflammation primarily through activation of the adaptive immune system may also be contributors. There are various types of acne, such as acne vulgaris, acne rosacea, acne cosmetica, acne fulminans, and acne mechanica.

Among them all, acne vulgaris is the most common, with prevalence in 99 percent of the acne cases. Acne vulgaris is a common inflammatory skin disease characterized by inflammatory or non-inflammatory lesions.

The prevalence of acne vulgaris globally was 681.2 million in 2016. This was an increase of 10 percent from 612 million in 2006.

In 2010, acne ranked 8thin the list of most prevalent diseases in the world, with a global prevalence of 645 million. Approximately 80 percent of people are affected by acne between onset of puberty and 30 years of age. In the US, the cost of acne in terms of treatment and loss of productivity is over 3 billion dollars per year.

In 2011, over 19.24 percent of the population in the US was affected with acne. However, the prevalence of acne vulgaris is expected to marginally decline over the forecast period 2017-2026, due to potential increase in elderly population and newer treatment approaches. By the end of 2026, the number of people affected by acne in India is estimated to reach 23 at a compound annual growth rate (CAGR) of 0.5 percent. In 2017, the estimated prevalence of acne in India was 22 million. Finally, the acne prevalence in Japan is relatively high compared some of the major European markets.

Dermatologic problems can result in psychosocial effects that seriously affect patient’s lives. More than a cosmetic nuisance, skin disease can produce anxiety, depression, and other psychological problems that affect patient’s lives in ways comparable to arthritis or other disabling illnesses.

Even though antibiotics play a key role in acne management, the increase in acnes resistance is a matter of concern. The issue of antibiotic resistance also impacts the prescribing patterns and treatment algorithms.
The standard of care for the treatment of mild-to-moderate acne is topical therapy. There are two treatment guidelines for treatment available by the American Academy of Dermatology and European Union Group.

The currently available therapeutic options for acne include several treatment approaches such as retinoids, antibacterial washes, antibiotic pills, lasers, pulsed-light therapies, photodynamic therapy, and systemic isotretinoin. There are multiple new breakthroughs we may see in the near future, which may include molecules with novel mechanisms and more effective dosage forms. The acne vulgaris product pipeline comprises diverse set of molecules with majority of products in early-stage development.

The global acne product pipeline comprises total of 64 programs at various stages of clinical development. 41 percent of products are in the preclinical and discovery stage. There are multiple promising molecules in clinical development that may potentially change the acne treatment approach in future.

Despite the size of the acne patient population, innovation in the acne therapy has remained limited over the past 20 years. Most of the innovation in acne therapy has involved reformulation of drugs with improved vehicles or development of a combination of approved products.

Poor adherence is one of the critical and negatively impacting factors affecting acne treatment outcomes. Moreover, limited patient education and awareness about acne treatment is also a roadblock to successful treatment.

Topical formulations are perhaps among the most challenging products to develop in terms of delivery of a drug to a target site. In addition, foams, micro lipid carriers (such as liposomes), microsphers, colloidal delivery systems, porous materials, and combination therapy options are also explored by the companies to come up with new drug delivery solutions to enhance the efficacy of the treatment.

The acne therapy market is moving from mono therapy towards combination therapy options. The most likely reason is higher efficacy of combinations that consider the multifactorial pathogenesis of acne, reduced resistance levels, and the ease of single product use versus two separate mono therapies.

This report provides in-depth market analysis of the global dermatology market, OTC dermatology product market and acne market. It also provides country-wise analysis of the above-mentioned market, the countries covered are the US, France, Germany, Spain, Italy, UK, Japan and India. The market size for dermatology therapeutics is expected to grow considerably, from USD 19.8billion in 2016 to USD 41.2billion in 2026, at a CAGR of 8 percent.

The global OTC dermatology products market was worth USD114billion in 2016. Acne treatments take a considerable share of dermatology OTC product market.

Also, increasingly various prescription acne treatments are becoming qualified as OTC products due to their history of long-term safety and efficacy. Products such as Benzoyl peroxide, Salicylic acid, and their combinations are largely moving into the OTC space. Accutane has been top selling product in the acne prescription market with sales of USD 1.2 billion in 2016.

The top assignee is Nestle, with 133 patents, followed by Allergan with 70 patents. Most of Nestlé’s patents belong to its subsidiary, Galderma, which is a Switzerland-based pharmaceutical subsidiary specializing in research and development (R&D) and marketing of dermatological solutions.

The patent with the maximum impact factor (maximum number of citations) is focused on oleaginous pharmaceutical and cosmetic foam for the treatment of acne this patent was cited by 91 patents. Among the top assignees provided by Market research, Nestle (Galderma), Allergan, Dow Chemical (DowDuPont), GlaxoSmithKline, and Sun Pharma appear as top assignees in the intellectual property (patent) search as well. The inventors with the maximum number of fillings are Donella, John E, and Mallard Claire.

Donella. John E is the most active inventor for Allergan and Mallard Claire has been the most active inventor for Nestle.

Companies profiled in this report include Novan Inc, Vyome Biosciences, Foamix Pharmaceuticals, BioPharmX Corporation and Paratek Pharmaceuticals.

Key Questions Answered
1. Detailed disease overview of acne.
2. Global epidemiology of acne; 2006-2026.
3. Epidemiology of acne by regions (US, EU5, Japan and India): 2011-2026.
4. Current treatment landscape of acne with list of approved products in each therapy including retinoids, antibiotics, benzoyl peroxide, hormonal therapy, light or photo therapy and others.
5. Treatment guidelines by America Academy of Dermatology and European Union Group.
6. Pipeline Analysis of acne by stage of development and molecule type.
7. Detailed analysis of promising drugs in clinical development such as topical Minocycline, Olumacostat Glasaretil, SB2014, Sarecycline HCL, VB1953.
8. Current unmet needs in acne market.
9. Opportunities in acne market like development of novel drug delivery systems etc.
10. Global dermatology market; 2016-2026.
11. Global dermatology market by regions (US, EU5, Japan, India): 2011-2026.
12. Global dermatology OTC products market; 2016-2026.
13. Global dermatology OTC product market regions (US, EU5, Japan, and India): 2011-2026.
14. Top selling acne market products; 2016.
15. Acne market by regions (US, EU5, Japan, India): 2011-2026.
16. Overall IP trends in acne market; 2012-2017.
17. Earliest priority country filing trend in acne market; 2012-2017.
18. Acne patent trend by focus area, dosage forms, route of administration and composition; 2012-2017.
19. Acne patent trend by key patent holder; 2012-2017.
20. Key patent holder in Indian acne market; 2012-2017.
21. Top inventors in acne market; 2012-2017.
22. Company analysis of Novan Inc, Vyome Biosciences, Foamix Pharmaceuticals, BioPharmX Corporation and Paratek Pharmaceuticals with their pipeline drugs.

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