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Alzheimer’s Disease: Update Bulletin [January 2018]

Alzheimer’s Disease: Update Bulletin [January 2018]

  • January 2018
  • ID: 5355977
  • Format: PDF
  • By Firstword Pharma

Summary

This edition presents the views and insights from three world leading key opinion leaders (KOLs) from North America and Europe on a variety of recent events in Alzheimer’s disease (AD) market, including; Novartis and Amgen, together with the Banner Alzheimer’s Institute, launching a new Phase II/III study with beta-secretase-1 inhibitor, CNP520 in an asymptomatic, high-risk population; IntelGenx initiating a Phase IIa study of Montelukast VersaFilm for patients with mild-to-moderate AD; ProMIS Neurosciences announcing results from a preclinical study of its next generation monoclonal antibody for AD, PMN310.

Business Questions:
• What are KOL’s current views on the amyloid theory of AD?
• Is research into preventative medications a feasible approach with the drug candidates that are currently available?
• What are the key barriers to research into disease prevention and modification?
• How does CNP520 compare to other BACE inhibitors?
• What do KOLs believe will be the best development strategy for Montelukast VersaFilm in AD?
• Is PMN310 sufficiently differentiated from other anti-amyloid antibodies to merit further research?
• How do experts rate the likelihood of success of these new developments?
• Do KOLs expect combination therapy to play a major role in the future treatment of AD?
• What are the barriers to combination therapy in AD?

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