1. Market Research
  2. > Healthcare
  3. > Health Services Market Trends
Drug Analysis: Atrasentan

Drug Analysis: Atrasentan

  • February 2018
  • 17 pages
  • ID: 5367927
  • Format: PDF
  • By Datamonitor Healthcare

Summary

Table of Contents

Drug Overview
Atrasentan (AbbVie) is a selective antagonist for the endothelin type A (ETA) receptor, also known as the endothelin 1 (ET-1) receptor. ET-1 is a peptide that can act at either the ETA or endothelin B (ETB) receptor.

The ETA receptor likely mediates several pathological effects of ET-1, including vasoconstriction, fibrosis, cell proliferation, and podocyte damage. The ETB receptor has some opposing actions, but is mainly involved in the regulation of fluid transport. The inhibition of ETA receptors decreases the binding affinity of ET-1 to the ETA receptor without affecting receptor density.

Atrasentan is currently in Phase III development in the US, Japan, and EU for the treatment of diabetic nephropathy (ClinicalTrials.gov identifier: NCT01858532).
The drug has a reasonably good chance of showing a benefit in its Phase III trial, although there is still uncertainty as to whether changes in the Phase II surrogate urinary albumin-to-creatinine ratio biomarker predict pivotal trial outcomes.

Concerns about fluid retention could hinder the drug until physicians gain more experience, even if the Phase III trial shows this to be manageable.

Atrasentan’s Phase III trial is unique in including an enrichment period to select responders and those who tolerate the drug for randomization. This should improve the chances for a positive trial and yield a relatively higher efficacy number, although efficacy in non-responders is also likely to be on the label and physicians in busy practices may not want to spend the time involved in a personalized approach if there are other options. Additionally, atrasentan may also be hampered commercially by limited data on cardiovascular outcomes.

Get Industry Insights. Simply.

  • Latest reports & slideshows with insights from top research analysts
  • 150+ Million searchable statistics with tables, figures & datasets
  • More than 25,000 trusted sources
  • Single User License — provides access to the report by one individual.
  • Department License — allows you to share the report with up to 5 users
  • Site License — allows the report to be shared amongst all employees in a defined country
  • Corporate License — allows for complete access, globally.
Ahmad helps you find the right report:
Testimonials

The research specialist advised us on the best content for our needs and provided a great report and follow-up, thanks very much we shall look at ReportLinker in the future.

Kate Merrick

Global Marketing Manager at
Eurotherm by Schneider Electric

We were impressed with the support that ReportLinker’s research specialists’ team provided. The report we purchased was useful and provided exactly what we want.

Category Manager at
Ikea

ReportLinker gave access to reliable and useful data while avoiding dispersing resources and spending too much time on unnecessary research.

Executive Director at
PwC Advisory

The customer service was fast, responsive, and 100% professional in all my dealings (...) If we have more research needs, I'll certainly prioritize working with ReportLinker!

Scott Griffith

Vice President Marketing at
Maurice Sporting Goods

The research specialist provided prompt, helpful instructions for accessing ReportLinker's product. He also followed up to make sure everything went smoothly and to ensure an easy transition to the next stage of my research

Jessica P Huffman

Research Associate at
American Transportation Research Institute

Excellent customer service. Very responsive and fast.

Director, Corporate Strategy at
Ingredion

I reached out to ReportLinker for a detailed market study on the Air Treatment industry. The quality of the report, the research specialist’s willingness to solve my queries exceeded my expectations. I would definitely recommend ReportLinker for in-depth industry information.

Mariana Mendoza

Global Platform Senior Manager at
Whirlpool Corporation

Thanks! I like what you've provided and will certainly come back if I need to do further research works.

Bee Hin Png

CEO at
LDR Pte Ltd

The research specialist advised us on the best content for our needs and provided a great report and follow-up, thanks very much we shall look at ReportLinker in the future.

Kate Merrick

Global Marketing Manager at
Eurotherm by Schneider Electric

FAQ
  • How we can help
    • I am not sure if the report I am interested in will fulfill my needs. Can you help me?
    • Yes, of course. You can call us at +33(0) 4 37 65 17 03 or drop us an email at researchadvisor@reportlinker.com to let us know more about your requirements.
    • We buy reports often - can ReportLinker get me any benefits?
    • Yes. Set up a call with a Senior Research Advisor to learn more - researchadvisor@reportlinker.com or +33(0) 4 37 65 17 03.
    • I have had negative experiences with market research reports before. How can you avoid this from happening again?
    • We advise all clients to read the TOC and Summary and list your questions so that we can get more insight for you before you make any purchase decision. A research advisor will accompany you so that you can compare samples and reports from different sources, and choose the study that is right for you.

  • Report Delivery
    • How and when I will receive my Report?
    • Most reports are delivered right away in a pdf format, while others are accessed via a secure link and access codes. Do note that sometimes reports are sent within a 12 hour period, depending on the time zones. However, you can contact us to escalate this. Should you need a hard copy, you can check if this option is offered for the particular report, and pay the related fees.
  • Payment conditions
    • What payment methods do you accept?
      1. Credit card : VISA, American Express, Mastercard, or
      2. You can download an invoice to pay by wire transfer, check, or via a Purchase Order from your company, or
      3. You can pay via a Check made out in US Dollars, Euros, or British Pounds for the full amount made payable to ReportLinker
    • What are ReportLinker’s Payment Terms?
    • All payments must normally be submitted within 30 days. However, you can let us know if you need extended time.
    • Are Taxes and duties included?
    • All companies based in France must pay a 20% tax per report. The same applies to all individuals based in the EU. All EU companies must supply their VAT number when purchasing to avoid this charge.
    • I’m not satisfied. Can I be refunded?
    • No. Once your order has been processed and the publisher has received a notification to send you the report, we cannot issue any refund or cancel any order. As these are not ‘traditional’ products that can be returned, reports that are dispatched are considered to be ‘consumed’.
  • User license
    • The license that you should acquire depends on the number of persons that need to access the report. This can range from Single User (only one person will have the right to read or access the report), or Department License (up to 5 persons), to Site License (a group of persons based in the same company location), or Corporate License (the entire company personnel based worldwide). However, as publishers have different terms and conditions, we can look into this for you.
Purchase Reports From Reputable Market Research Publishers
Global Molecular Forensics Market: Focus on Product, Technology Application, End User, Country Data (16 Countries), and Competitive Landscape – Analysis and Forecast, 2019-2029

Global Molecular Forensics Market: Focus on Product, Technology Application, End User, Country Data (16 Countries), and Competitive Landscape – Analysis and Forecast, 2019-2029

  • $ 5000
  • November 2019

Global Molecular Forensics Market to Grow at a CAGR of 9.09% from 2019-2029Key Questions Answered in this Report:• What are the major market drivers, challenges, and opportunities in the global molecula ...

Auto-Immune Diseases Diagnostic Tests - Medical Devices Pipeline Assessment, 2019

Auto-Immune Diseases Diagnostic Tests - Medical Devices Pipeline Assessment, 2019

  • $ 4000
  • December 2019

Auto-Immune Diseases Diagnostic Tests - Medical Devices Pipeline Assessment, 2019SummaryMedical Devices sector report, “Auto-Immune Diseases Diagnostic Tests - Medical Devices Pipeline Assessment, 2019" ...

Multiplex Biomarker Imaging Market - Global Industry Analysis and Opportunity Assessment, 2019-2029

Multiplex Biomarker Imaging Market - Global Industry Analysis and Opportunity Assessment, 2019-2029

  • $ 5000
  • December 2019

A recent market study published on the multiplex biomarker imaging market includes global industry analysis for 2014-2018 and opportunity assessment for 2019-2029, and delivers a comprehensive assessment ...

Global Cardiac Biomarkers Industry $ 5450 February 2020


ref:plp2018

Reportlinker.com © Copyright 2020. All rights reserved.

ReportLinker simplifies how Analysts and Decision Makers get industry data for their business.

Make sure you don’t miss any news and follow us on