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Global Renal Cell Carcinoma Market Report - 2028

Global Renal Cell Carcinoma Market Report - 2028

  • January 2018
  • 100 pages
  • ID: 5371976
  • Format: PDF
  • EffeMarket

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Renal cell carcinoma (RCC), also known as kidney cancer or renal adenocarcinoma, is the most common type of kidney cancer in adults. It occurs at an average age of 64 years. RCC is a disease which develops in the lining of the kidney tubules and grows into a mass or tumor. It accounts for approximately 3 percent of adult malignancies and 90 to 95 percent of malignant neoplasm (cancer cells) involving the kidneys.

RCC occurs when DNA within the renal cells becomes damaged and the cycle of cell life and death is no longer normal. It typically begins as one or more tumor masses in a single kidney, but at times it develops in both kidneys at the same time. Its signs and symptoms include weight loss, fever, hypertension, malaise, night sweats, and blood in the urine.

Kidney cancer is the twelfth most common cancer diagnosed in the world. The age-adjusted incidence has been rising by 3 percent per year. In general, men are twice as prone to RCC as women. According to the Globocan cancer statistics, in 2012 the incidence was 3,37,860. Of this number, 63 percent of cases were men and 37 percent of cases were women. It is forecasted that 598,512 new cases will emerge in 2028 with a compound annual growth rate (CAGR) of 3 percent. Annually, 143,000 deaths are caused by kidney cancers. The National Cancer Institute estimated that approximately 63,990 people would be diagnosed with RCC in the US in 2017. In the US alone, almost 14,000 deaths occur from RCC each year. In the EU in 2012, there were approximately 84,000 cases and 35,000 deaths due to RCC.

Sutent is currently the standard of care for first-line treatment, while Afinitor is the standard of care in the second-line of treatment. Currently, these are usually given as monotherapy. But now, clinical trials are in progress to see if combination therapy (with standard therapy, other approved drugs or new molecules) is better than monotherapy.

Renal Cell Carcinoma Pipeline Analysis Report: 2017 includes list of pipeline of drugs in clinical development, and pipeline analysis by phase, indication sub-type, molecule type and company. The report provides the detailed analysis of the key five promising drugs in clinical development which are Savolitinib, AGS-003, Atezolizumab, Tivozanib and Avelumab.

More of the companies are exploring the possibility of combining the in-development molecules with standard therapies or immunotherapies. These companies are focused on developing treatment for the advanced/metastatic form of kidney cancer. Bristol-Myers Squibb, in collaboration with Ono Pharmaceutical, is leading in this space. Other leading companies in this area are Novartis, Roche, Eisai, Merck & Co. (as Merck Sharp & Dohme), AstraZeneca, Pfizer and Takeda. Very few companies like Bristol-Myers Squibb, Novartis, Eisai and Roche are investing on the rare variant, the non-clear cell RCC.

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