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Market Spotlight: Small-Cell Lung Cancer (SCLC), Pharma Intelligence

Market Spotlight: Small-Cell Lung Cancer (SCLC), Pharma Intelligence

  • October 2019
  • 64 pages
  • ID: 5779887
  • Format: PDF
  • By Pharma Intelligence

Summary

Table of Contents

This Market Spotlight report covers the small cell lung cancer market, comprising key pipeline and marketed drugs, recent events and analyst opinion, probability of success, clinical trials, upcoming and regulatory events, patent information, a 10-year disease incidence forecast, licensing and acquisition deals, and drug-specific revenue forecasts.

Key Takeaways
The analyst estimates that in 2017, there were 310,300 incident cases of small cell lung cancer (SCLC) worldwide, and forecasts that number to increase to 339,500 incident cases by 2026.
Northern America is estimated to have the highest disease incidence of SCLC (10.43 per 100,000 people), while Africa has the lowest incidence (0.47 per 100,000 people).
Approved drugs for SCLC focus on targets such as DNA, topoisomerase I, programmed death-1 receptor/programmed death ligands, and the immune system. These drugs are administered via the oral or intravenous routes.
The majority of industry-sponsored drugs in active clinical development for SCLC are in Phase II. Therapies in development for SCLC focus on a wide variety of targets. The majority of drugs in development for SCLC are administered via the intravenous route, with the remainder being oral, intratumoral, intramuscular, or subcutaneous formulations.
High-impact upcoming events for drugs in the SCLC space comprise topline Phase I/II trial results for Pegzilarginase, topline Phase II/III trial results for Unituxin, and topline Phase III trial results for Zepsyre and Keytruda.
The overall likelihood of approval of a Phase I solid tumors asset is 5.5%, and the average probability a drug advances from Phase III is 39.9%. Drugs, on average, take 9.5 years from Phase I to approval, compared to 9.3 years in the overall oncology space.
There have been 14 licensing and asset acquisition deals involving SCLC drugs during 2014–19. The largest deal was the $356m licensing agreement made in 2017 between CytRx and NantCell for the exclusive rights to develop and market aldoxorubicin.
The distribution of clinical trials across Phase I–IV indicates that the vast majority of trials for SCLC have been in the early and mid-phases of development, with 89% of trials in Phase I–II, and only 11% in Phase III–IV.
The US has a substantial lead in the number of SCLC clinical trials globally. The UK leads the major EU markets, while Japan has the top spot in Asia.
Clinical trial activity in the SCLC space is dominated by completed trials. GlaxoSmithKline and Pfizer have the highest number of completed clinical trials for SCLC, with 42 and 41 trials, respectively.
Pfizer leads industry sponsors with the highest overall number of clinical trials for SCLC, followed by GlaxoSmithKline and BristolMyers Squibb.

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