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Ublituximab

Ublituximab

  • January 2019
  • 43 pages
  • ID: 5780233
  • Format: PDF
  • By Pharma Intelligence

Summary

Table of Contents

Drug Overview
Ublituximab (TG Therapeutics/LFB Biotechnologies) is an anti-CD20 monoclonal antibody, currently in late-stage trials across a range of hematological and neurological indications. CD20 is a cell-surface antigen expressed on most B cells, and the depletion of these cells suppresses the autoimmune response within both relapsing and progressive forms of multiple sclerosis (MS). Its primary indication is chronic lymphocytic leukemia (CLL), although the proof-of-concept for B-cell depletion established by Ocrevus in MS has encouraged TG Therapeutics to explore ublituximab’s broader clinical effect.
LFB Biotechnologies originally discovered ublituximab, and sold worldwide commercial rights to TG Therapeutics in 2012. TG Therapeutics subsequently initiated several clinical trials to support the development and eventual commercialization of ublituximab, its lead candidate. These include the Phase III GENUINE and UNITY programs in CLL and non-Hodgkin’s lymphoma, as well as the ULTIMATE I and II trials in relapsing MS. In southeast Asia and South Korea, TG Therapeutics has out-licensed ublituximab to Ildong.

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