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Market Spotlight: Chemotherapy-Induced Anemia

Market Spotlight: Chemotherapy-Induced Anemia

  • November 2019
  • 32 pages
  • ID: 5807922
  • Format: PDF
  • By Pharma Intelligence

Summary

Table of Contents

This Market Spotlight report covers the chemotherapy-induced anemia market, comprising key marketed and pipeline drugs, clinical trials, regulatory events, probability of success, epidemiology information, and licensing and acquisition deals, as well as presenting drug-specific revenue forecasts.

Key Takeaways
Chemotherapy-induced anemia (CIA) is a common complication in cancer patients receiving chemotherapy. The proportions of CIA and the severity of anemia vary by region, cancer type, and stage.
All of the approved drugs for CIA target the erythropoietin receptor. These drugs are all administered via both the intravenous and subcutaneous routes.
There are only two industry-sponsored drugs in active clinical development for CIA, both of which are in Phase III. Therapies in development for CIA focus on targets such as iron and hypoxia-inducible factor-prolyl hydroxylase (HIF-PH). These drugs are administered via the intravenous and oral routes.
The only high-impact upcoming event in the CIA space is topline Phase III trial results for roxadustat. The overall likelihood of approval of a Phase I marrow or peripheral blood stimulator asset is 18.9%, and the average probability a drug advances from Phase III is 66.7%. Drugs, on average, take 9.0 years from Phase I to approval, compared to 9.3 years in the overall hematology space.
There have been only two licensing and asset acquisition deals involving CIA drugs during 2014–19. The values of the deals have not been disclosed.
The distribution of clinical trials across Phase I–IV indicates that the majority of trials for CIA have been in the late phases of development, with 61% of trials in Phase III–IV, and 39% in Phase I–II.
Clinical trial activity in the CIA space is dominated by completed trials. Amgen has the highest number of completed clinical trials for CIA, with 67 trials.
Amgen leads industry sponsors with the highest number of clinical trials for CIA, followed by Johnson and Johnson.

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