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Prosthetic joint infection (PJI)– Epidemiology Forecast—2030

Prosthetic joint infection (PJI)– Epidemiology Forecast—2030

  • April 2020
  • 80 pages
  • ID: 5879442
  • Format: PDF
  • Delve Insight

Summary

Table of Contents

‘Prosthetic joint infection (PJI)– Epidemiology Forecast—2030’ report delivers an in-depth understanding of the PJI, historical and forecasted epidemiology in the United States, EU5 (Germany, Spain, Italy, France, and the United Kingdom) and Japan.

Prosthetic joint infection (PJI) Disease Understanding
Prosthetic joint infection (PJI), also known as peri-prosthetic infection is defined as an infection involving the joint prosthesis and adjacent tissue. It is one of the significant complications and etiologies of implant failure after joint replacement and associated with a substantial financial burden on the healthcare system, and significant physical and psychological morbidity on patients. The majority of PJIs occurring within 1 year of surgery are initiated through the introduction of microorganisms at the time of surgery and this can occur through either direct contact or aerosolized contamination of the prosthesis or periprosthetic tissue. The most common observed microorganism responsible for PJI is S. aureus bacteremia. Along with this, Coagulase-negative staphylococci, Streptococcus species, Enterococcus species, and aerobic Gram-negative bacilli also play an essential role in the infection.

The clinical manifestations of PJI may include pain, swelling in joint or effusion, erythema or warmth around the joint, fever, drainage, or the presence of a sinus tract communicating with the arthroplasty and others. However, pain is observed as the most frequently reported clinical manifestation. The factors which are responsible for PJI are Diabetes mellitus, Rheumatoid arthritis, male gender, smoking, etc. The diagnosis of PJI continues to be a significant challenge in clinical practice. As an early diagnosis of the condition can improve the therapeutic success rates for PJI tremendously, diagnostic techniques have received increasing consideration from multidisciplinary teams involved in managing PJI. A wide range of diagnostic techniques that have been established in the diagnosis of PJI, along with some novel techniques could become essential diagnostics in the future.

Prosthetic joint infection (PJI) Epidemiology
The PJI epidemiology division provides insights about the historical and current patient pool along with the forecasted trend for every seven major countries. It helps to recognize the causes of current and forecasted trends by exploring numerous studies and views of key opinion leaders. This part of The report also provides the diagnosed patient pool and their trends along with assumptions undertaken.

Key Findings
The total prevalent cases of Prosthetic joint infection (PJI) patients are increasing in 7MM during the study period, i.e. 2017-2030.
The disease epidemiology covered in the report provides historical as well as forecasted PJI symptoms epidemiology segmented as the Total prevalence of Arthroplasty, Total prevalence of PJI, Gender-Specific cases of PJI, Causative Microorganism-specific cases of PJI. The report includes the prevalent scenario of PJI symptoms in 7MM covering the United States, EU5 countries (Germany, France, Italy, Spain, and the United Kingdom), and Japan from 2017 to 2030.


Country Wise- Prosthetic joint infection (PJI) Epidemiology
The epidemiology segment also provides the Prosthetic joint infection (PJI) epidemiology data and findings across the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom) and Japan.
The total prevalent population of PJI Associated in 7MM countries was found to be 58,832 in in 2017.
• As per the estimates, the United States has the highest prevalent population of PJI.
• Among the EU5 countries, Germany had the highest prevalent population of PJI, followed by the UK. On the other hand, France had the lowest prevalent population with 1,595 cases in 2017.


Scope of the Report
• The Prosthetic joint infection (PJI) report covers a detailed overview explaining its causes, symptoms, classification, pathophysiology, diagnosis and treatment patterns
• The Prosthetic joint infection (PJI) Epidemiology Report and Model provide an overview of the risk factors and global trends of Prosthetic joint infection (PJI) in the seven major markets (7MM: US, France, Germany, Italy, Spain, UK, and Japan)
• The report provides insight about the historical and forecasted patient pool of Prosthetic joint infection (PJI) in seven major markets covering the United States, EU5 (Germany, Spain, France, Italy, UK) and Japan
• The report helps to recognize the growth opportunities in the 7MM with respect to the patient population
• The report assesses the disease risk and burden and highlights the unmet needs of PJI
• The report provides the segmentation of the Prosthetic joint infection (PJI) epidemiology by Prevalent Cases of Prosthetic joint infection (PJI) in 7MM.
• The report provides the segmentation of the Prosthetic joint infection (PJI) epidemiology by gender-specific Prevalent Cases of Prosthetic joint infection (PJI) in 7MM.
• The report provides the segmentation of the Prosthetic joint infection (PJI) epidemiology by age-specific Prevalent Cases of Prosthetic joint infection (PJI) in 7MM.
• The report provides the segmentation of the Prosthetic joint infection (PJI) epidemiology by Causative Microorganism-specific Cases of Prosthetic joint infection (PJI) in 7MM


Report Highlights

• 11-Year Forecast of Prosthetic joint infection (PJI) epidemiology
• 7MM Coverage
• Total Prevalent Cases of Prosthetic joint infection (PJI)
• Prevalent Cases according to segmentation: Gender-specific Prevalence of PJI
• Prevalent Cases according to segmentation: Causative Microorganism-specific Prevalence of PJI
• Diagnosed cases of PJI

KOL- Views
We interview, KOLs and SME’s opinion through primary research to fill the data gaps and validate our secondary research. The opinion helps to understand the total patient population and current treatment pattern. This will support the clients in potential upcoming novel treatment by identifying the overall scenario of the indications.

Key Questions Answered
• What is the trend of Arthroplasties in joint replacement in the coming years? At what rate it is increasing or decreasing.
• What will be the growth opportunities in the 7MM with respect to the patient population pertaining to PJI?
• What are the key findings pertaining to the Prosthetic joint infection (PJI) epidemiology across 7MM and which country will have the highest number of patients during the forecast period (2017–2030)?
• What would be the total number of patients of Prosthetic joint infection (PJI) across the 7MM during the forecast period (2017–2030)?
• Among the EU5 countries, which country will have the highest number of patients during the forecast period (2017–2030)?
• At what CAGR the patient population is expected to grow in 7MM during the forecast period (2017–2030)?
• What is the disease risk, burden and unmet needs of the PJI?
• What are the currently available treatments of PJI?


Reasons to buy
The Prosthetic joint infection (PJI) Epidemiology report will allow the user to -
• Develop business strategies by understanding the trends shaping and driving the global Prosthetic joint infection (PJI) market
• Quantify patient populations in the global Prosthetic joint infection (PJI) market to improve product design, pricing, and launch plans
• Organize sales and marketing efforts by identifying the age groups and sex that present the best opportunities for Prosthetic joint infection (PJI) therapeutics in each of the markets covered
• Understand the magnitude of Prosthetic joint infection (PJI) population by its Prevalence cases
• Understand the magnitude of Prosthetic joint infection (PJI) population by its Gender-specific cases
• Understand the magnitude of Prosthetic joint infection (PJI) population by its Causative Microorganism-specific Prevalence
• The Prosthetic joint infection (PJI) epidemiology report and model were written and developed by Masters and Ph.D. level epidemiologists
• The Prosthetic joint infection (PJI) Epidemiology Model developed is easy to navigate, interactive with dashboards, and epidemiology based on transparent and consistent methodologies. Moreover, the model supports data presented in the report and showcases disease trends over 11-year forecast period using reputable sources

Key Assessments
• Patient Segmentation
• Disease Risk and Burden
• Risk of disease by the segmentation
• Factors driving growth in a specific patient population

Geographies Covered
• The United States
• EU5 (Germany, France, Italy, Spain, and the United Kingdom)
• Japan
Study Period: 2017–2030
The 2001-2009 Nationwide Inpatient Sample was used to identify total hip and knee arthroplasties using the International Classification of Diseases, Ninth Revision, procedure codes. The relative incidence of PJI is increasing over time.
In the United States, the most common organisms are methicillin-resistant and methicillin-sensitive S. aureus, and methicillin-resistant and methicillin-sensitive S. epidermidis. Infections lead to a high mortality rate and the two-stage hip revisions for infection have up to 25.8% all-cause mortality within 2 years.

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