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Cytokine Release Syndrome (CRS)- Epidemiology Forecast - 2030

Cytokine Release Syndrome (CRS)- Epidemiology Forecast - 2030

  • June 2020
  • 100 pages
  • ID: 5921867
  • Format: PDF
  • Delve Insight

Summary

Table of Contents

‘Cytokine Release Syndrome (CRS)-Epidemiology Forecast–2030’ report delivers an in-depth understanding of the Cytokine Release Syndrome (CRS), historical and forecasted epidemiology as well as the Cytokine Release Syndrome trends in the United States, EU5 (Germany, France, Italy, Spain, and United Kingdom) and Japan.

Cytokine Release Syndrome (CRS) Understanding
Cytokine release syndrome (CRS) is a systemic inflammatory response that can be triggered by a variety of factors such as infections and certain drugs causing pathologic over-activation of T cells, leading to hypersecretion of cytokines by T cells and other immune cell types.

The symptoms of CRS typically occur within 30–120 min after the infusion has been initiated, and typically the risk is greater during the first infusion. After CAR T-cell therapy, the onset of CRS symptoms seems to be dependent on the administered dose of the active agent of the proliferation kinetics of adoptively transferred cells and ranges from a few minutes up to 14 days but usually occurs within the first week.

<>Cytokine Release Syndrome (CRS) Epidemiology Perspective
The disease epidemiology covered in the report provides historical as well as forecasted epidemiology segmented by Total Number of B-cell NHL Patients receiving CART-Therapies, Total Number of Acute lymphoblastic leukemia (ALL) Patients receiving CART-Therapies, Total Number of Multiple Myeloma (MM) Patients receiving CART-Therapies, Total Number of Patients developing Cytokine Release Syndrome (CRS) following CART therapies, and Total Number of Patients Developing Cytokine Release Syndrome (CRS) by Severity/Grade, scenario of CRS in the 7MM covering the United States, EU5 countries (Germany, France, Italy, Spain, and United Kingdom) and Japan from 2017 to 2030.

<>Cytokine Release Syndrome (CRS) Detailed Epidemiology Segmentation
• Total number of patients who develop Cytokine Release Syndrome following CART therapies in the 7MM were 31 in 2017.
• Total number of Hematologic malignancies (Includes ALL, B-Cell NHL (DLBCL, FL, PMBCL, etc.), and Multiple Myeloma) patients receiving CART-therapies in the 7MM were observed to be 41 in 2017. These cases will increase in the 7MM throughout the study period, i.e., 2017–2030.
• Both the therapies Yescarta (Axicabtagene ciloleucel, Kite/Gilead) and Kymriah (Tisagenlecleucel, Novartis) were approved in 2017 in the United States and 2018 in EU-5. Kymriah is the only CAR-T cell therapy, which was approved in Japan in 2019
• Among the European 5 countries, Germany had the highest population of CRS with 13 cases, followed by France and the United Kingdom with 11 cases respectively. On the other hand, Spain had the lowest population of 6 cases in 2018.
• Based on the severity criteria, CRS has been classified into Grade 1, 2, 3, and 4. Out of the total population of CRS 31 cases in the US, the highest cases were observed in the grade 1 & 2, and lowest cases accounted in grade 4 in 2017.
• There is no CAR-T therapy which is approved for Multiple Myeloma (MM) patients. According to the report, there are around 6-8 emerging CAR-T cell therapies which are expected to launch during forecast period for the treatment of MM and patients will experience cytokine release syndrome. As comparison to Yescarta (Axicabtagene ciloleucel, Kite/Gilead) and Kymriah (Tisagenlecleucel, Novartis), new CAR-T cell therapies that are going to be approved in forecast period, will show lower incidence of Cytokine Release Syndrome based on the preliminary results.

Scope of the Report
• The report covers the descriptive overview of Cytokine Release Syndrome (CRS), explaining its causes, signs and symptoms, pathogenesis and currently available therapies.
• The report provides insight into the 7MM historical and forecasted patient pool covering the United States, EU5 countries (Germany, France, Italy, Spain, and United Kingdom) and Japan.
• The report assesses the disease risk and burden and highlights the unmet needs of Cytokine Release Syndrome (CRS).
• The report helps to recognize the growth opportunities in the 7MM with respect to the patient population.
• The report provides the segmentation of the disease epidemiology for 7MM by Total Number of B-cell NHL Patients receiving CART-Therapies, Total Number of Acute lymphoblastic leukemia (ALL) Patients receiving CART-Therapies, Total Number of Multiple Myeloma (MM) Patients receiving CART-Therapies, Total Number of Patients developing Cytokine Release Syndrome (CRS) following CART therapies, and Total Number of Patients Developing Cytokine Release Syndrome (CRS) by Severity/Grade.

Report Highlights
• 11-Year Forecast of Cytokine Release Syndrome (CRS)
• 7MM Coverage
• Total Number of B-cell NHL Patients receiving CART-Therapies
• Total Number of Acute lymphoblastic leukemia (ALL) Patients receiving CART-Therapies
• Total Number of Multiple Myeloma (MM) Patients receiving CART-Therapies
• Total Number of Patients developing Cytokine Release Syndrome (CRS) following CART therapies
• Total Prevalence of Cytokine Release Syndrome (CRS) based on Risk
• Total Number of Patients Developing Cytokine Release Syndrome (CRS) by Severity/Grade.

Key Questions Answered
• What is the disease risk, burden and unmet needs of Cytokine Release Syndrome (CRS)?
• What is the historical Cytokine Release Syndrome (CRS) patient pool in the United States, EU5 (Germany, France, Italy, Spain, and the UK) and Japan?
• What would be the forecasted patient pool of Cytokine Release Syndrome (CRS) at the 7MM level?
• What will be the growth opportunities across the 7MM with respect to the patient population pertaining to Cytokine Release Syndrome (CRS)?
• Out of the above-mentioned countries, which country would have the highest prevalent population of Cytokine Release Syndrome (CRS) during the forecast period (2020–2030)?

Reasons to buy
The Cytokine Release Syndrome (CRS) report will allow the user to -
• Develop business strategies by understanding the trends shaping and driving the 7MM Cytokine Release Syndrome (CRS) epidemiology forecast.
• The Cytokine Release Syndrome (CRS) epidemiology report and model were written and developed by Masters and Ph.D. level epidemiologists.
• The Cytokine Release Syndrome (CRS) epidemiology model developed is easy to navigate, interactive with dashboards, and epidemiology based on transparent and consistent methodologies. Moreover, the model supports data presented in the report and showcases disease trends over the eleven-year forecast period using reputable sources.

Key Assessments

<>• Patient Segmentation
• Disease Risk and Burden

<>• Risk of disease by the segmentation
• Factors driving growth in a specific patient population

Geographies Covered
• The United States
• EU5 (Germany, France, Italy, Spain, and the United Kingdom)
• Japan
Study Period: 2017–2030

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