1. Market Research
  2. > Pharmaceutical
  3. > Therapy Market Trends
Lymphangioleiomyomatosis (LAM) - Pipeline Insight, 2020

Lymphangioleiomyomatosis (LAM) - Pipeline Insight, 2020

  • November 2020
  • 60 pages
  • ID: 5989624
  • Format: PDF
  • Delve Insight

Summary

Table of Contents

“Lymphangioleiomyomatosis– Pipeline Insight, 2020,” report provides comprehensive insights about 10+ companies and 10+ pipeline drugs in Lymphangioleiomyomatosis pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered
• Global coverage

Lymphangioleiomyomatosis Understanding

Lymphangioleiomyomatosis: Overview
Lymphangioleiomyomatosis (LAM) also known as lymphangiomyomatosis is a condition that affects the lungs, the kidneys, and the lymphatic system. The lymphatic system consists of a network of vessels that transport lymph fluid and immune cells throughout the body. Lymph fluid helps exchange immune cells, proteins, and other substances between the blood and tissues. LAM is found almost exclusively in women. It often occurs as a feature of an inherited syndrome called tuberous sclerosis complex. When LAM occurs alone it is called isolated or sporadic LAM.

Symptoms
Signs and symptoms of LAM most often appear during a woman’s thirties. Affected women have an overgrowth of abnormal smooth muscle-like cells (LAM cells) in the lungs, resulting in the formation of lung cysts and the destruction of normal lung tissue. They may also have an accumulation of fluid in the cavity around the lungs (chylothorax). The lung abnormalities resulting from LAM may cause difficulty breathing (dyspnea), chest pain, and coughing, which may bring up blood (hemoptysis). Many women with this disorder have recurrent episodes of collapsed lung (spontaneous pneumothorax).

Diagnosis
Routine investigations can be supportive but not diagnostic in LAM. The chest radiograph often appears normal in early disease, although may show a pneumothorax or pleural effusion. The most common abnormalities are reticulonodular shadowing and cysts or bullae. The lung volumes are generally preserved and the combination of preserved lung volumes and interstitial changes occurs in a small number of conditions including LAM, Langerhans’ cell histiocytosis, sarcoidosis and chronic hypersensitivity pneumonitis.

Treatment
Standard treatment of lymphangioleiomyomatosis is lung transplantation, but the disorder can recur in transplanted lungs. Rapamune (sirolimus) has been approved to treat lymphangioleiomyomatosis (LAM), a rare progressive lung disease that primarily affects women of childbearing age. Rapamune is manufactured by Wyeth Pharmaceuticals, Inc., a subsidiary of Pfizer, Inc. Treatment with sirolimus is recommended for patients with abnormal or declining lung function. Alternative treatments, such as hormonal manipulation with progestins, tamoxifen, and oophorectomy, are largely ineffective and not recommended.

Lymphangioleiomyomatosis Emerging Drugs Chapters
This segment of the Lymphangioleiomyomatosis report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I and preclinical. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

Lymphangioleiomyomatosis Emerging Drugs
• Rapamycin- AI Therapeutics
LAM-001 is the world’s first inhaled mTOR inhibitor and designed to treat the rare lung disease, lymphangioleiomyomatosis. LAM is a genetic-based disease found primarily in women and characterized by hyperactivation of mTOR signaling. LAM-001 has completed clinical trials in normal healthy volunteers and in patients with LAM disease.
• Saracatinib: AstraZeneca
Saracatinib is a small molecule, highly-potent and selective inhibitor of src tyrosine kinase. The drug is currently in phase II stage of development for the treatment of LAM.
Further product details are provided in the report……..

Lymphangioleiomyomatosis: Therapeutic Assessment
This segment of the report provides insights about the different Lymphangioleiomyomatosis drugs segregated based on following parameters that define the scope of the report, such as:
• Major Players in Lymphangioleiomyomatosis
There are approx. 10+ key companies which are developing the therapies for Lymphangioleiomyomatosis. The companies which have their Lymphangioleiomyomatosis drug candidates in the most advanced stage, i.e. phase II include, AI Therapeutics.
• Phases
report covers around 10+ products under different phases of clinical development like
• Late stage products (BLA Filed and Phase III)
• Mid-stage products (Phase II and
• Early-stage products (Phase I) along with the details of
• Pre-clinical and Discovery stage candidates
• Discontinued & Inactive candidates

• Route of Administration
Lymphangioleiomyomatosis pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as
• Infusion
• Intradermal
• Intravenous
• Intravesical
• Oral etc.
• Molecule Type
Products have been categorized under various Molecule types such as
• Antineoplastics
• Vaccine
• Gene therapies
• Immunotherapy
• Metal
• Monoclonal antibodies
• Nanoparticle
• Oncolytic viruses
• Peptide
• Plasmid
• Protein
• Small molecule
• Ligand
• Bacteria and others.

• Product Type
Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Lymphangioleiomyomatosis: Pipeline Development Activities
The report provides insights into different therapeutic candidates in phase III, II, I and preclinical stage. It also analyses Lymphangioleiomyomatosis therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Lymphangioleiomyomatosis drugs.

Report Highlights
• The companies and academics are working to assess challenges and seek opportunities that could influence Lymphangioleiomyomatosis R&D. The therapies under development are focused on novel approaches to treat/improve Lymphangioleiomyomatosis.
Lymphangioleiomyomatosis Report Insights
• Lymphangioleiomyomatosis Pipeline Analysis

• Therapeutic Assessment
• Unmet Needs
• Impact of Drugs

Lymphangioleiomyomatosis Report Assessment
• Pipeline Product Profiles

• Therapeutic Assessment

• Pipeline Assessment

• Inactive drugs assessment
• Unmet Needs

Key Questions
Current Treatment Scenario and Emerging Therapies:
• How many companies are developing Lymphangioleiomyomatosis drugs?
• How many Lymphangioleiomyomatosis drugs are developed by each company?
• How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Lymphangioleiomyomatosis?
• What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Lymphangioleiomyomatosis therapeutics?
• What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
• What are the clinical studies going on for Lymphangioleiomyomatosis and their status?
• What are the key designations that have been granted to the emerging drugs?

Key Players
• AI Therapeutics
• AstraZeneca

Key Products
• Rapamycin
• Saracatinib

Get Industry Insights. Simply.

  • Latest reports & slideshows with insights from top research analysts
  • 150+ Million searchable statistics with tables, figures & datasets
  • More than 25,000 trusted sources
  • Single User License — provides access to the report by one individual.
  • Department License — allows you to share the report with up to 5 users
  • Site License — allows the report to be shared amongst all employees in a defined country
  • Corporate License — allows for complete access, globally.

ReportLinker may already be registered as a supplier with your company. If you want to Order by PO, check with us first and we'll let you know if we are a registered supplier and what the vendor number is. Otherwise, we'll provide you with the necessary information to register ReportLinker as a vendor.

Ahmad helps you find the right report:
Testimonials

The research specialist advised us on the best content for our needs and provided a great report and follow-up, thanks very much we shall look at ReportLinker in the future.

Kate Merrick

Global Marketing Manager at
Eurotherm by Schneider Electric

We were impressed with the support that ReportLinker’s research specialists’ team provided. The report we purchased was useful and provided exactly what we want.

Category Manager at
Ikea

ReportLinker gave access to reliable and useful data while avoiding dispersing resources and spending too much time on unnecessary research.

Executive Director at
PwC Advisory

The customer service was fast, responsive, and 100% professional in all my dealings (...) If we have more research needs, I'll certainly prioritize working with ReportLinker!

Scott Griffith

Vice President Marketing at
Maurice Sporting Goods

The research specialist provided prompt, helpful instructions for accessing ReportLinker's product. He also followed up to make sure everything went smoothly and to ensure an easy transition to the next stage of my research

Jessica P Huffman

Research Associate at
American Transportation Research Institute

Excellent customer service. Very responsive and fast.

Director, Corporate Strategy at
Ingredion

I reached out to ReportLinker for a detailed market study on the Air Treatment industry. The quality of the report, the research specialist’s willingness to solve my queries exceeded my expectations. I would definitely recommend ReportLinker for in-depth industry information.

Mariana Mendoza

Global Platform Senior Manager at
Whirlpool Corporation

Thanks! I like what you've provided and will certainly come back if I need to do further research works.

Bee Hin Png

CEO at
LDR Pte Ltd

The research specialist advised us on the best content for our needs and provided a great report and follow-up, thanks very much we shall look at ReportLinker in the future.

Kate Merrick

Global Marketing Manager at
Eurotherm by Schneider Electric

FAQ
  • How we can help
    • I am not sure if the report I am interested in will fulfill my needs. Can you help me?
    • Yes, of course. You can call us at +33(0) 4 37 65 17 03 or drop us an email at [email protected] to let us know more about your requirements.
    • We buy reports often - can ReportLinker get me any benefits?
    • Yes. Set up a call with a Senior Research Advisor to learn more - [email protected] or +33(0) 4 37 65 17 03.
    • I have had negative experiences with market research reports before. How can you avoid this from happening again?
    • We advise all clients to read the TOC and Summary and list your questions so that we can get more insight for you before you make any purchase decision. A research advisor will accompany you so that you can compare samples and reports from different sources, and choose the study that is right for you.

  • Report Delivery
    • How and when I will receive my Report?
    • Most reports are delivered right away in a pdf format, while others are accessed via a secure link and access codes. Do note that sometimes reports are sent within a 12 hour period, depending on the time zones. However, you can contact us to escalate this. Should you need a hard copy, you can check if this option is offered for the particular report, and pay the related fees.
  • Payment conditions
    • What payment methods do you accept?
      1. Credit card : VISA, American Express, Mastercard, or
      2. You can download an invoice to pay by wire transfer, check, or via a Purchase Order from your company, or
      3. You can pay via a Check made out in US Dollars, Euros, or British Pounds for the full amount made payable to ReportLinker
    • What are ReportLinker’s Payment Terms?
    • All payments must normally be submitted within 30 days. However, you can let us know if you need extended time.
    • Are Taxes and duties included?
    • All companies based in France must pay a 20% tax per report. The same applies to all individuals based in the EU. All EU companies must supply their VAT number when purchasing to avoid this charge.
    • I’m not satisfied. Can I be refunded?
    • No. Once your order has been processed and the publisher has received a notification to send you the report, we cannot issue any refund or cancel any order. As these are not ‘traditional’ products that can be returned, reports that are dispatched are considered to be ‘consumed’.
  • User license
    • The license that you should acquire depends on the number of persons that need to access the report. This can range from Single User (only one person will have the right to read or access the report), or Department License (up to 5 persons), to Site License (a group of persons based in the same company location), or Corporate License (the entire company personnel based worldwide). However, as publishers have different terms and conditions, we can look into this for you.
Purchase Reports From Reputable Market Research Publishers

Research Efforts Fuel the Future of Global Obstructive Lung Disease Management

  • $ 4950
  • August 2021
  • 80 pages

Respiratory diseases are on the rise globally due to various factors, including environmental ones.Obstructive lung diseases such as chronic obstructive pulmonary disease (COPD), asthma, and cystic fibrosis ...

  • World
  • Respiratory Disease
  • Therapy
  • Industry analysis

ref:plp2020

Reportlinker.com © Copyright 2021. All rights reserved.

ReportLinker simplifies how Analysts and Decision Makers get industry data for their business.

Make sure you don’t miss any news and follow us on