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Biliary Tract Cancers (BTCs) - Epidemiology Forecast to 2030

Biliary Tract Cancers (BTCs) - Epidemiology Forecast to 2030

  • January 2021
  • 80 pages
  • ID: 6010467
  • Format: PDF
  • Delve Insight

Summary

Table of Contents

‘Biliary Tract Cancer (BTC) – Epidemiology Forecast—2030’ report delivers an in-depth understanding of the historical and forecasted epidemiology of biliary tract cancer in the United States, EU5 (Germany, Spain, Italy, France, and the United Kingdom), and Japan.

Geographies Covered
• The United States
• EU5 (Germany, France, Italy, Spain, and the United Kingdom)
• Japan
Study Period: 2017–2030
According to the Cholangiocarcinoma Foundation, about 8,000 people in the US are diagnosed with cholangiocarcinoma each year. It can occur at younger ages but is most common in older people, and the average age of diagnosis is 70–75. It is much more common in Asia and the Middle East, mostly because of the bile duct’s common parasitic infection

Biliary Tract Cancer: Disease Understanding

Biliary Tract Cancer Overview
Biliary Tract Cancer constitutes epithelial malignancies of the biliary tree and include the following: gallbladder cancer (GBC), intrahepatic CCA (iCCA) and extrahepatic CCA (eCCA). The extrahepatic disease may be split into perihilar (Klatskin’s tumor) and distal CCA.
BTC constitutes approximately 3% of all gastrointestinal malignancies and is the most common hepatobiliary cancer after hepatocellular carcinoma. Primary sclerosing cholangitis (PSC), primary biliary cirrhosis (PBC), cirrhosis due to other causes, hepatitis C and congenital malformations such as choledochal cysts and multiple biliary papillomatosis are also associated with an increased risk of developing BTC. In addition, patients with germline mutations resulting in Lynch syndrome and BRCA1 and BRCA2 (breast cancer gene 1 and 2) genetic aberrations are also predisposed to BTC.
Gallbladder cancer originates in the cells of the gallbladder, and most are adenocarcinomas, which begin in the gland cells of the gallbladder lining. While, CCA is an epithelial malignancy originating from transformed cholangiocytes, with preclinical studies suggesting hepatic progenitor cells as the origin. iCCA can emerge at any point in the intrahepatic biliary tree, ranging from mian bile ducts to the segmental bile ducts. In contrast to HCC, iCCA usually develops in non-cirrhotic liver. pCCA can arise in the right and/or left hepatic duct and/or at their junction (so-called perihilar bile ducts), and dCCA involves the common bile duct. The current term extrahepatic cholangiocarcinoma (eCCA) is now discouraged from using as it combines subtypes with distinct clinicopathological features, origins, prognosis, and therapeutic options. Ampullary cancer originates in the area where the common bile duct meets the pancreatic duct, which is called the Ampulla of Vater.

Inflammation and cholestasis are key factors in cholangiocarcinogenesis. Next-generation sequencing has identified somatic mutations in oncogenes (i.e., KRAS), tumor suppressor (i.e., TP53 and SMAD4), and chromatin-modifying genes (i.e., ARID1A, BAP1, and PBMR1) in CCA. Furthermore, the tumor commonly metastasizes via lymphatic spread to the regional lymph nodes, followed by hematogenous metastasis to the liver, lungs, and peritoneum. The majority of cholangiocarcinomas are adenocarcinomas with variable grades of differentiation (mainly well-differentiated adenocarcinomas), although several uncommon types are also encountered, such as adenosquamous, squamous, mucinous, and anaplastic carcinomas. Jaundice and abdominal pain are the most common presentations of BTC.

A diagnosis of biliary tract cancer is usually based on the results of clinical examination of the abdomen, imaging scans using ultrasound, magnetic resonance imaging (MRI) or computed tomography (CT), and a biopsy. Further investigations can help to determine how advanced the cancer is (the ‘stage’). For example, MRI of the biliary tract, a CT scan of the chest and an ultrasound scan of the lymph nodes are commonly used to see how far cancer has spread. Biliary tract cancer is staged according to tumor size, whether it has spread to the lymph nodes and whether it has spread into the liver, lungs or other parts of the body. This information is used to help decide the best treatment.

Treatment options for the early-stage disease include surgery followed by adjuvant chemotherapy. For patients with locally advanced disease, locoregional therapies (e.g., trans-arterial chemoembolization (TACE) and external beam radiation therapy (EBRT) may be considered. However, these have not yet been validated in prospective randomized controlled trials, and therefore, their use is very variable. For patients with locally advanced and metastatic disease, the combination of gemcitabine and cisplatin has been shown to improve survival.

Biliary Tract Cancer: Epidemiology
The Biliary Tract Cancer epidemiology division provides insights about the historical and current patient pool, along with the forecasted trend for every seven major countries. It helps recognize the causes of current and forecasted trends by exploring numerous studies and views of key opinion leaders. This part of the report also provides the diagnosed patient pool and their trends along with assumptions undertaken.

Key Findings
The disease epidemiology covered in the report provides historical and forecasted Biliary Tract Cancer epidemiology segmented as the total incident cases of biliary tract cancer, age-specific cases of biliary tract cancer, stage-specific cases of biliary tract cancer and mutation-specific cases of biliary tract cancer. The report includes the incident scenario of biliary tract cancer in the 7MM covering the United States, EU5 countries (Germany, France, Italy, Spain, and the United Kingdom), and Japan from 2017 to 2030.

Country-wise Biliary Tract Cancer Epidemiology
The epidemiology segment also provides the biliary tract cancer epidemiology data and findings across the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan.
The total incident population of biliary tract cancer in the 7MM countries was estimated to be 70,111 cases in 2017.
As per the estimates, in 2017, the United States had the highest incident population of biliary tract cancer. Among the EU5 countries, Germany had the highest incident population of biliary tract cancer with 6,918 cases, followed by Italy in 2017. On the other hand, Spain had the lowest incident population of 2,908 cases in 2017.

Scope of the Report
• Biliary Tract Cancer report covers a detailed overview explaining its causes, symptoms, classification, pathophysiology, diagnosis, and treatment patterns.
• Biliary Tract Cancer Epidemiology Report and Model provide an overview of the risk factors and global trends of biliary tract cancer in the seven major markets (7MM: US, France, Germany, Italy, Spain, UK, and Japan).
• The report provides insight into the historical and forecasted patient pool of biliary tract cancer in seven major markets covering the United States, EU5 (Germany, Spain, France, Italy, UK), and Japan
• The report helps recognize the growth opportunities in the 7MM with respect to the patient population.
• The report assesses the disease risk and burden and highlights the unmet needs of biliary tract cancer.
• The report provides the segmentation of the biliary tract cancer epidemiology by total incident cases of biliary tract cancer in the 7MM
• The report provides the segmentation of the biliary tract cancer epidemiology by age-specific cases of biliary tract cancer, stage-specific cases of biliary tract cancer and mutation-specific cases of biliary tract cancer in the 7MM.

Report Highlights

• 11-year Forecast of Biliary Tract Cancer epidemiology
• 7MM Coverage
• Total Incident Cases of Biliary Tract Cancer
• Age-specific Cases of Biliary Tract Cancer
• Mutation-specific Cases of Biliary Tract Cancer
• Stage-specific Cases of Biliary Tract Cancer

KOL Views
We interview KOLs and obtain SME’s opinion through primary research to fill the data gaps and validate our secondary research. The opinion helps understand the total patient population and current treatment pattern. This will support the clients in potential upcoming novel treatment by identifying the overall scenario of the indications.

Key Questions Answered
• What will be the growth opportunities in the 7MM for the patient population pertaining to biliary tract cancer?
• What are the key findings pertaining to the biliary tract cancer epidemiology across 7MM, and which country will have the highest number of patients during the forecast period (2017–2030)?
• What would be the total number of patients of biliary tract cancer across the 7MM during the forecast period (2017–2030)?
• Among the EU5 countries, which country will have the highest number of patients during the forecast period (2017–2030)?
• At what CAGR the patient population is expected to grow by in the 7MM during the forecast period (2017–2030)?
• What are the disease risk, burdens, and unmet needs of biliary tract cancer?
• What are the currently available treatments for biliary tract cancer?

Reasons to buy

Biliary Tract Cancer Epidemiology report will allow the user to:
• Develop business strategies by understanding the trends shaping and driving the global biliary tract cancer market
• Quantify patient populations in the global biliary tract cancer market to improve product design, pricing, and launch plans
• Organize sales and marketing efforts by identifying the age groups and sex that present the best opportunities for biliary tract cancer therapeutics in each of the markets covered
• Understand the magnitude of biliary tract cancer population by its incident cases.
• Understand the magnitude of biliary tract cancer population by its age-specific cases, stage-specific cases and mutation-specific cases.
• The biliary tract cancer epidemiology report and model were written and developed by Masters and PhD level epidemiologists
• The biliary tract cancer Epidemiology Model developed is easy to navigate, interactive with dashboards, and epidemiology based on transparent and consistent methodologies. Moreover, the model supports data presented in the report and showcases disease trends over an 11-year forecast period using reputable sources

Key Assessments
• Patient Segmentation
• Disease Risk and Burden
• Risk of disease by the segmentation
• Factors driving growth in a specific patient population

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