1. Market Research
  2. > Healthcare
  3. > Health Services Market Trends
Granulomatosis with Polyangiitis - Epidemiology Forecast to 2030

Granulomatosis with Polyangiitis - Epidemiology Forecast to 2030

  • April 2021
  • 60 pages
  • ID: 6064463
  • Format: PDF
  • Delve Insight


Table of Contents

‘Granulomatosis with polyangiitis (GPA) – Epidemiology Forecast – 2030’ report delivers an in-depth understanding of the historical and forecasted epidemiology of GPA in the United States, EU5 (Germany, Spain, Italy, France, and the United Kingdom), and Japan.

Granulomatosis with polyangiitis (GPA): Disease Understanding

GPA Overview
Granulomatosis with polyangiitis (GPA, formerly known as Wegener’s granulomatosis) is an autoimmune small-vessel vasculitis that is highly associated with anti-neutrophil cytoplasmic antibodies (ANCA). According to the Chapel Hill criteria (2012), GPA is defined as necrotizing granulomatous inflammation usually involving the upper and lower respiratory tract, and necrotizing vasculitis affecting predominantly small-to-medium vessels (e.g., capillaries, venules, arterioles, arteries, and veins).
The disease was initially described by Klinger in 1931 as a variant of polyarteritis nodosa and was defined for the first time as a separated syndrome by Friedrich Wegener. Godman and Churg (1954) introduced the term ‘Wegener’s granulomatosis’ and further delineated the clinical and pathological features.
Two phenotypes are distinguished in GPA that are localized and systemic with the possible transition during disease. Typically, patients initially suffer from a limited form that may consist of constitutional symptoms and localized manifestations, such as chronic sinusitis, rhinitis, otitis media, ocular conditions, and/or skin lesions. More serious manifestations may arise in later stages, including pulmonary complications and glomerulonephritis, although the skin, eyes, and heart may also be involved. Classically, the acronym ELK is used to describe the clinical involvement of the ear, nose, and throat (ENT), lungs, and kidneys.
The etiology of GPA is linked to environmental and infectious triggers inciting disease onset in genetically predisposed individuals. Anti-neutrophil cytoplasmic antibodies are pathogenic and play an important role in the pathogenesis of this disease. Pathological processes involved include aberrant epigenetic expression of proteinase-3 on the cell membrane of neutrophils and the formation of antibodies against proteinase-3 (PR3-ANCA). The binding of PR3-ANCA to PR3 activates neutrophils, and there is a release of neutrophilic inflammatory mediators, the formation of neutrophil extracellular traps that lead to complement activation and damage to endothelial cells of small blood vessels.
Diagnosis of GPA is achieved through clinical assessment, serological tests for anti-neutrophil cytoplasmic antibodies (ANCA), and histological analysis. Biopsy, imaging, and laboratory tests are involved. Symptoms of microscopic polyangiitis (MPA), eosinophilic granulomatosis with polyangiitis (EGPA), Goodpasture syndrome (GPS), polyarteritis nodosa (PAN), lymphomatous granulomatosis (LyG), and systemic rheumatological disorders can be similar to those of GPA for which differential diagnosis is useful.
The treatment of GPA involves Induction therapy as the first phase, which aims to quickly put the disease into remission and lasts about 3–6 months according to the clinical response, and maintenance therapy as the second phase that lasts 12–24 months to consolidate the remission and limit the risk of relapse. The standard therapy for GPA is a combination of glucocorticoids and cyclophosphamide/ rituximab. Adjuvant therapy and plasma exchange are also involved.
The early diagnosis and specific treatment of GPA are important but difficult to achieve because of the multiplicity of presenting symptoms and unclear histological features. Talking about the pathogenesis of GPA, it has undergone many advances and progressed over the years. Hopefully, this will be translated into the development of new and better therapies for patients.

Granulomatosis with polyangiitis: Epidemiology
The GPA epidemiology division provides insights into the historical and current patient pool, along with the forecasted trend for every seven major countries. It helps recognize the causes of current and forecasted trends by exploring numerous studies and views of key opinion leaders. This part of the report also provides the diagnosed patient pool and their trends, along with assumptions undertaken.

Key Findings
The disease epidemiology covered in the report provides historical and forecasted GPA epidemiology segmented as the Incident cases of granulomatosis with polyangiitis, Gender-specific cases of granulomatosis with polyangiitis and Age-specific cases of granulomatosis with polyangiitis. The report includes the incident scenario of GPA in the 7MM covering the United States, EU5 countries (Germany, France, Italy, Spain, and the United Kingdom), and Japan from 2018 to 2030.

Country-wise GPA Epidemiology
The epidemiology segment also provides the GPA epidemiology data and findings across the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan.
The total incident population of GPA in the 7MM countries was estimated to be 7,618 cases in 2020.
As per the estimates, the United States had the largest incidence of granulomatosis with polyangiitis in 2020. Among the EU5 countries, Germany had the largest incident population of GPA with 2,722 cases, followed by the UK in 2020. On the other hand, Italy had the lowest incident population of 150 cases in 2020.

Scope of the Report
• GPA report covers a detailed overview explaining its causes, symptoms, classification, pathophysiology, diagnosis, and treatment patterns.
• GPA Epidemiology Report and Model provide an overview of the risk factors and global GPA trends in the seven major markets (7MM: US, France, Germany, Italy, Spain, UK, and Japan).
• The report provides insight into the historical and forecasted patient pool of GPA in seven major markets covering the United States, EU5 (Germany, Spain, France, Italy, UK), and Japan
• The report helps recognize the growth opportunities in the 7MM concerning the patient population.
• The report assesses the disease risk and burden and highlights the unmet needs of granulomatosis with polyangiitis.
• The report provides the segmentation of the GPA epidemiology by incident cases of GPA in the 7MM
• The report provides the segmentation of the GPA epidemiology by gender-specific cases of GPA in the 7MM.
• The report provides the segmentation of the GPA epidemiology by age-specific cases of GPA in the 7MM.

Report Highlights

• 10-year Forecast of GPA epidemiology
• 7MM Coverage
• Incident Cases of Granulomatosis with polyangiitis
• Gender-specific Cases of Granulomatosis with polyangiitis
• Age-specific Cases of Granulomatosis with polyangiitis

KOL Views
We interview KOLs and obtain SME’s opinion through primary research to fill the data gaps and validate our secondary research. The opinion helps understand the total patient population and current treatment pattern. This will support the clients in potential upcoming novel treatment by identifying the overall scenario of the indications.

Key Questions Answered
• What will be the growth opportunities in the 7MM for the patient population pertaining to GPA?
• What are the key findings pertaining to the granulomatosis with polyangiitis epidemiology across 7MM, and which country will have the highest number of patients during the forecast period (2018–2030)?
• What would be the total number of patients with granulomatosis with polyangiitis across the 7MM during the forecast period (2018–2030)?
• Among the EU5 countries, which country will have the highest number of patients during the forecast period (2018–2030)?
• At what CAGR the patient population is expected to grow by in the 7MM during the forecast period (2018–2030)?
• What are the disease risk, burdens, and unmet needs of granulomatosis with polyangiitis?
• What are the currently available treatments for granulomatosis with polyangiitis?

Reasons to buy
GPA Epidemiology report will allow the user to:
• Develop business strategies by understanding the trends shaping and driving the global GPA market
• Quantify patient populations in the global granulomatosis with polyangiitis market to improve product design, pricing, and launch plans
• Organize sales and marketing efforts by identifying the age groups and sex that present the best opportunities for granulomatosis with polyangiitis therapeutics in each of the markets covered
• Understand the magnitude of the granulomatosis with polyangiitis population by its incident cases.
• Understand the magnitude of the granulomatosis with polyangiitis population by its gender-specific cases.
• Understand the magnitude of the granulomatosis with polyangiitis population by its age-specific cases.
• The GPA epidemiology report and model were written and developed by Masters and PhD level epidemiologists
• The GPA Epidemiology Model developed is easy to navigate, interactive with dashboards, and epidemiology based on transparent and consistent methodologies. Moreover, the model supports data presented in the report and showcases disease trends over a 10-year forecast period using reputable sources

Key Assessments
• Patient Segmentation
• Disease Risk and Burden
• Risk of disease by the segmentation
• Factors driving growth in a specific patient population

Geographies Covered
• The United States
• EU5 (Germany, France, Italy, Spain, and the United Kingdom)
• Japan

Study Period: 2018–2030
Granulomatosis with Polyangiitis (GPA), formerly known as Wegener’s Granulomatosis is a rare systemic necrotizing vasculitis that affects small and medium-sized blood vessels. As per the classification on the Modern Nomenclature of Systemic Vasculitides laid down at the Chapel Hill Consensus Conference in 2012, GPA is a component of a vast spectrum of disorders entitled the anti-neutrophil-cytoplasmic-antibody (ANCA) associated vasculitides (AAV). AAV includes granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA or Churg–Strauss Syndrome). Among these three ANCA-associated vasculitides, GPA is the most common. The annual worldwide incidence of GPA is estimated to be 10-20 cases per one million based upon the geographical location. A higher incidence is noted in the colder regions.

Get Industry Insights. Simply.

  • Latest reports & slideshows with insights from top research analysts
  • 150+ Million searchable statistics with tables, figures & datasets
  • More than 25,000 trusted sources
  • Single User License — provides access to the report by one individual.
  • Department License — allows you to share the report with up to 5 users
  • Site License — allows the report to be shared amongst all employees in a defined country
  • Corporate License — allows for complete access, globally.

ReportLinker may already be registered as a supplier with your company. If you want to Order by PO, check with us first and we'll let you know if we are a registered supplier and what the vendor number is. Otherwise, we'll provide you with the necessary information to register ReportLinker as a vendor.

Ahmad helps you find the right report:

The research specialist advised us on the best content for our needs and provided a great report and follow-up, thanks very much we shall look at ReportLinker in the future.

Kate Merrick

Global Marketing Manager at
Eurotherm by Schneider Electric

We were impressed with the support that ReportLinker’s research specialists’ team provided. The report we purchased was useful and provided exactly what we want.

Category Manager at

ReportLinker gave access to reliable and useful data while avoiding dispersing resources and spending too much time on unnecessary research.

Executive Director at
PwC Advisory

The customer service was fast, responsive, and 100% professional in all my dealings (...) If we have more research needs, I'll certainly prioritize working with ReportLinker!

Scott Griffith

Vice President Marketing at
Maurice Sporting Goods

The research specialist provided prompt, helpful instructions for accessing ReportLinker's product. He also followed up to make sure everything went smoothly and to ensure an easy transition to the next stage of my research

Jessica P Huffman

Research Associate at
American Transportation Research Institute

Excellent customer service. Very responsive and fast.

Director, Corporate Strategy at

I reached out to ReportLinker for a detailed market study on the Air Treatment industry. The quality of the report, the research specialist’s willingness to solve my queries exceeded my expectations. I would definitely recommend ReportLinker for in-depth industry information.

Mariana Mendoza

Global Platform Senior Manager at
Whirlpool Corporation

Thanks! I like what you've provided and will certainly come back if I need to do further research works.

Bee Hin Png

CEO at
LDR Pte Ltd

The research specialist advised us on the best content for our needs and provided a great report and follow-up, thanks very much we shall look at ReportLinker in the future.

Kate Merrick

Global Marketing Manager at
Eurotherm by Schneider Electric

  • How we can help
    • I am not sure if the report I am interested in will fulfill my needs. Can you help me?
    • Yes, of course. You can call us at +33(0) 4 37 65 17 03 or drop us an email at researchadvisor@reportlinker.com to let us know more about your requirements.
    • We buy reports often - can ReportLinker get me any benefits?
    • Yes. Set up a call with a Senior Research Advisor to learn more - researchadvisor@reportlinker.com or +33(0) 4 37 65 17 03.
    • I have had negative experiences with market research reports before. How can you avoid this from happening again?
    • We advise all clients to read the TOC and Summary and list your questions so that we can get more insight for you before you make any purchase decision. A research advisor will accompany you so that you can compare samples and reports from different sources, and choose the study that is right for you.

  • Report Delivery
    • How and when I will receive my Report?
    • Most reports are delivered right away in a pdf format, while others are accessed via a secure link and access codes. Do note that sometimes reports are sent within a 12 hour period, depending on the time zones. However, you can contact us to escalate this. Should you need a hard copy, you can check if this option is offered for the particular report, and pay the related fees.
  • Payment conditions
    • What payment methods do you accept?
      1. Credit card : VISA, American Express, Mastercard, or
      2. You can download an invoice to pay by wire transfer, check, or via a Purchase Order from your company, or
      3. You can pay via a Check made out in US Dollars, Euros, or British Pounds for the full amount made payable to ReportLinker
    • What are ReportLinker’s Payment Terms?
    • All payments must normally be submitted within 30 days. However, you can let us know if you need extended time.
    • Are Taxes and duties included?
    • All companies based in France must pay a 20% tax per report. The same applies to all individuals based in the EU. All EU companies must supply their VAT number when purchasing to avoid this charge.
    • I’m not satisfied. Can I be refunded?
    • No. Once your order has been processed and the publisher has received a notification to send you the report, we cannot issue any refund or cancel any order. As these are not ‘traditional’ products that can be returned, reports that are dispatched are considered to be ‘consumed’.
  • User license
    • The license that you should acquire depends on the number of persons that need to access the report. This can range from Single User (only one person will have the right to read or access the report), or Department License (up to 5 persons), to Site License (a group of persons based in the same company location), or Corporate License (the entire company personnel based worldwide). However, as publishers have different terms and conditions, we can look into this for you.
Purchase Reports From Reputable Market Research Publishers

Systemic Sclerosis (Scleroderma) - Epidemiology Forecast to 2030

  • $ 3995
  • May 2021
  • 42 pages

Systemic Sclerosis (Scleroderma) - Epidemiology Forecast to 2030 Summary Systemic sclerosis (SSc) is an autoimmune disorder of small arteries, microvessels, and connective tissue.SSc is characterized ...

  • United States
  • Italy
  • Musculoskeletal Disorder
  • Epidemiology
  • Industry analysis
  • Prescription Drug Sales
  • Health Provider Density


Reportlinker.com © Copyright 2021. All rights reserved.

ReportLinker simplifies how Analysts and Decision Makers get industry data for their business.

Make sure you don’t miss any news and follow us on