1. Market Research
  2. > Pharmaceutical
  3. > Drug Development Market Trends
Global TIGIT Inhibitor Drug Opportunity & Clinical Research Insight 2022

Global TIGIT Inhibitor Drug Opportunity & Clinical Research Insight 2022

  • December 2021
  • 120 pages
  • ID: 6189155
  • Format: PDF
  • Kuick Research

Summary

Table of Contents

Global TIGIT Inhibitor Drug Opportunity & Clinical Research Insight 2022 Report Highlights:

• Global TIGIT Inhibitor Market Dynamics
• Clinical Approaches to Target TIGIT
• Role of TIGIT Inhibitors in Cancer, HIV, Autoimmune Disorders
• Number of TIGIT Inhibitor Drug In Trials
• TIGIT Inhibitors Trials By Phase, Company, Country, Indication
• Clinical Trials Adverse Events Scenario
• Company Agreement/Partnership/Deals For Ongoing Trials
• Global TIGIT Inhibitor Market Future Outlook

T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is one of the most recently identified immune checkpoint inhibitor which is being evaluated as potential immunotherapeutic target. TIGIT is transmembrane glycoprotein receptor with Ig-like V-type domain and an ITIM in its cytoplasmic domain and is expressed on wide range of cells including memory T-cells, NK cells, and Tregs. Apart from this, studies have demonstrated high expression of TIGIT on wide range of solid tumors and hematological malignancies, thus making it potential target in drug development.

Several pharmaceutical companies have developed a robust pipeline of TIGIT inhibitors in their pipeline indicated for the management of several cancers. Current clinical trials are mainly evaluating the role of TIGIT inhibitors in combination with PD-1/PD-L1 inhibitor or CTLA-4 inhibitors. Immunotherapy combinations featuring dual blockade of TIGIT and PD-1/PD-L1 are promising due to their synergistic enhancement of antitumor responses. More recently, Compugen in colloaboration with Bristol Meyer Squibb is evaluating triple combination of Opdivo, BMS-986207 (anti-TIGIT), and COM701 (anti-PVRIG). The preliminary data suggest that the triple combination was safe and well tolerated.

Apart from cancer, researchers are also evaluating the role of novel immune checkpoint in other therapeutic conditions including HIV and autoimmune disorders. TIGIT has emerged out to be attractive target in HIV due to its expression on NK cells and almost all HIV-specific CD8+ T cells. Preclinical studies have favored the co-blockade of TIGIT with PD-1/PD-L1 inhibitor in HIV patients. The encouraging response from preclinical trials is expected to be translated in clinical studies in coming years. Further, researchers have also suggested the relationship between TIGIT expressing Treg cells and different autoimmune diseases including atopic dermatitis, autoimmune thyroiditis, type-1 diabetes, autoimmune uveitis, aplastic anemia, multiple sclerosis, systemic lupus erythematous, arthritis, and colitis. As of now, these studies are mainly confined to in-vivo and preclinical studies.

Currently, the market for TIGIT inhibitor is mainly domination by therapeutic monoclonal antibodies. Several monoclonal antibodies targeting TIGIT have entered the clinical development including Tiragolumab, Ociperlimab, Vibostolimab, ASP-8374, and COM902. Further enhancement in the field of biotechnology and promising results of TIGIT inhibitor in combinational therapies have led to the development of novel bispecific constructs. Currently, a few bispecific antibodies including AGEN1777, IBI321 and HLX301 have entered initial stages of clinical trials. The emergence of bispecific antibody constructs is expected to show enhanced efficacy and will reduce the overall cost of therapy and drug development.

Globally, there are more than 30 clinical trials ongoing which are evaluating novel anti-TIGIT antibodies in wide range of diseases. Some of the major indications which are anticipated to show a better outcome by the launch of these drugs include triple negative breast cancer, non-small cell lung cancer, colorectal cancer, melanoma, gastric cancer, and esophageal cancer. The global market is anticipated to show positive growth due to launch of TIGIT therapies during forthcoming years. Tiragolumab developed by Roche is leading drug candidate which has received priority review by US FDA and is expected to be launched in market by 2022. The emerging trend in TIGIT next generation immunotherapies with continuous headway movement along with the development of new technologies for the development of targeted therapies provides hope for better therapeutic alternatives in coming years.

US will dominate the TIGIT Inhibitor development and commercialization landscape which is mainly attributed to large number of ongoing clinical trials in the region. Further, the high concentration of key players in the region which actively invest in research and development will also propel the growth of market. Beside US, China and South Korea will also emerge as key markets for TIGIT inhibitors drugs driven by increasing research and development activities.

Get Industry Insights. Simply.

  • Latest reports & slideshows with insights from top research analysts
  • 150+ Million searchable statistics with tables, figures & datasets
  • More than 25,000 trusted sources
  • Single User License — provides access to the report by one individual.
  • Department License — allows you to share the report with up to 5 users
  • Site License — allows the report to be shared amongst all employees in a defined country
  • Corporate License — allows for complete access, globally.

ReportLinker may already be registered as a supplier with your company. If you want to Order by PO, check with us first and we'll let you know if we are a registered supplier and what the vendor number is. Otherwise, we'll provide you with the necessary information to register ReportLinker as a vendor.

Ahmad helps you find the right report:
Testimonials

The research specialist advised us on the best content for our needs and provided a great report and follow-up, thanks very much we shall look at ReportLinker in the future.

Kate Merrick

Global Marketing Manager at
Eurotherm by Schneider Electric

We were impressed with the support that ReportLinker’s research specialists’ team provided. The report we purchased was useful and provided exactly what we want.

Category Manager at
Ikea

ReportLinker gave access to reliable and useful data while avoiding dispersing resources and spending too much time on unnecessary research.

Executive Director at
PwC Advisory

The customer service was fast, responsive, and 100% professional in all my dealings (...) If we have more research needs, I'll certainly prioritize working with ReportLinker!

Scott Griffith

Vice President Marketing at
Maurice Sporting Goods

The research specialist provided prompt, helpful instructions for accessing ReportLinker's product. He also followed up to make sure everything went smoothly and to ensure an easy transition to the next stage of my research

Jessica P Huffman

Research Associate at
American Transportation Research Institute

Excellent customer service. Very responsive and fast.

Director, Corporate Strategy at
Ingredion

I reached out to ReportLinker for a detailed market study on the Air Treatment industry. The quality of the report, the research specialist’s willingness to solve my queries exceeded my expectations. I would definitely recommend ReportLinker for in-depth industry information.

Mariana Mendoza

Global Platform Senior Manager at
Whirlpool Corporation

Thanks! I like what you've provided and will certainly come back if I need to do further research works.

Bee Hin Png

CEO at
LDR Pte Ltd

The research specialist advised us on the best content for our needs and provided a great report and follow-up, thanks very much we shall look at ReportLinker in the future.

Kate Merrick

Global Marketing Manager at
Eurotherm by Schneider Electric

FAQ
  • How we can help
    • I am not sure if the report I am interested in will fulfill my needs. Can you help me?
    • Yes, of course. You can call us at +33(0) 4 37 65 17 03 or drop us an email at [email protected] to let us know more about your requirements.
    • We buy reports often - can ReportLinker get me any benefits?
    • Yes. Set up a call with a Senior Research Advisor to learn more - [email protected] or +33(0) 4 37 65 17 03.
    • I have had negative experiences with market research reports before. How can you avoid this from happening again?
    • We advise all clients to read the TOC and Summary and list your questions so that we can get more insight for you before you make any purchase decision. A research advisor will accompany you so that you can compare samples and reports from different sources, and choose the study that is right for you.

  • Report Delivery
    • How and when I will receive my Report?
    • Most reports are delivered right away in a pdf format, while others are accessed via a secure link and access codes. Do note that sometimes reports are sent within a 12 hour period, depending on the time zones. However, you can contact us to escalate this. Should you need a hard copy, you can check if this option is offered for the particular report, and pay the related fees.
  • Payment conditions
    • What payment methods do you accept?
      1. Credit card : VISA, American Express, Mastercard, or
      2. You can download an invoice to pay by wire transfer, check, or via a Purchase Order from your company, or
      3. You can pay via a Check made out in US Dollars, Euros, or British Pounds for the full amount made payable to ReportLinker
    • What are ReportLinker’s Payment Terms?
    • All payments must normally be submitted within 30 days. However, you can let us know if you need extended time.
    • Are Taxes and duties included?
    • All companies based in France must pay a 20% tax per report. The same applies to all individuals based in the EU. All EU companies must supply their VAT number when purchasing to avoid this charge.
    • I’m not satisfied. Can I be refunded?
    • No. Once your order has been processed and the publisher has received a notification to send you the report, we cannot issue any refund or cancel any order. As these are not ‘traditional’ products that can be returned, reports that are dispatched are considered to be ‘consumed’.
  • User license
    • The license that you should acquire depends on the number of persons that need to access the report. This can range from Single User (only one person will have the right to read or access the report), or Department License (up to 5 persons), to Site License (a group of persons based in the same company location), or Corporate License (the entire company personnel based worldwide). However, as publishers have different terms and conditions, we can look into this for you.
Purchase Reports From Reputable Market Research Publishers

Psoriatic Arthritis (Musculoskeletal) - Drugs in Development, 2021

  • $ 2000
  • October 2021
  • 379 pages

Psoriatic Arthritis (Musculoskeletal) - Drugs in Development, 2021 Summary This latest Pharmaceutical and Healthcare disease pipeline guide Psoriatic Arthritis - Drugs In Development, 2021, provides an ...

  • South Africa
  • Jiangsu
  • Autoimmune Disease
  • Drug Development
  • Industry analysis
  • Pharmaceutical Registrations
  • Drug Approval

ref:plp2021

Reportlinker.com © Copyright 2022. All rights reserved.

ReportLinker simplifies how Analysts and Decision Makers get industry data for their business.

Make sure you don’t miss any news and follow us on