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Global Synthetic Small Molecule API Market Size, Share & Industry Trends Analysis Report By Manufacturer, By Application, By Regional Outlook and Forecast, 2022 – 2028

Global Synthetic Small Molecule API Market Size, Share & Industry Trends Analysis Report By Manufacturer, By Application, By Regional Outlook and Forecast, 2022 – 2028

  • September 2022
  • 203 pages
  • ID: 6352785
  • Format: PDF
  • KBV Research

Summary

Table of Contents

The Global Synthetic Small Molecule API Market size is expected to reach $187.8 billion by 2028, rising at a market growth of 5.4% CAGR during the forecast period.

A molecule called or micromolecule is a low molecular weight organic chemical that may control a biological process and has a size of about 1 nm in the domains of molecular biology and pharmacology. Small molecules make up many medications; the words are interchangeable in the literature.

Although their component monomers (amino acids, ribo or deoxyribonucleotides, and monosaccharides, respectively) are frequently regarded as small molecules, larger structures like nucleic acids, proteins, and many polysaccharides are not small molecules. Small molecules can be employed as research tools to examine biological processes and as a source of inspiration for the creation of novel therapeutics.

Some can prevent a protein from performing a certain function or interfere with protein-protein interactions. The term "small molecule" is typically used in pharmacology to refer to molecules that bind to particular biological macromolecules and work as an effector to change the activity or serve of the target. Small molecules can be used biologically for a wide range of purposes, including as medications, insecticides, cell signaling molecules, and many other things. These substances may be synthetic (like antiviral medications) or natural (like secondary metabolites), and they may be advantageous or harmful in the fight against the disease.

A tiny molecule can have a maximum molecular weight of about 900 Daltons, which enables it to swiftly diffuse across a cellular membrane and reach intracellular areas of action. This molecular weight cutoff enables transcellular transport through intestinal epithelial cells, which is another necessary but inadequate criterion for oral bioavailability. In addition to intestinal permeability, the chemical must also have a moderate to low first-pass metabolism, a moderately quick rate of dissolution into water, and appropriate water solubility.

COVID-19 Impact Analysis

The COVID-19 pandemic has helped the market expand by motivating participants to geographically spread their operations to prevent shortages. Due to the compromised respiratory system function in infected patients, the need for APIs eventually increased during the pandemic. The investigation of small molecule products is being advanced by COVID-19. Additionally, research is being done to find new uses for currently available small molecule medications to treat SARS-CoV-2 illness. The significant effects of the COVID-19 outbreak have had a variety of effects on people’s health all across the world. The tremendous social and economic burden on individuals around the world is related to the aftermath.

Market Growth Factor

Increasing Use of Personalized Medicine

The aforementioned technological developments are also giving researchers a better understanding of the unique characteristics of smaller groups of disorders that were previously thought to be prevalent in all patients. For instance, the effect of particular genetic alterations on how responsively various tumors respond to various types of therapy is now more understood.

The rates of cardiovascular, cancer and infectious diseases are rising alarmingly

The healthcare industry’s technological improvements present this market with enormous growth potential. More R&D is made possible by the expansion of the healthcare infrastructure. Small molecule API will be used increasingly frequently as medication development research accelerates. The powers of small molecule pharma will also be revealed. Businesses that offer small molecule API will have more prospects in the years to come.

Market Restraining Factor

Lack of Trained and Skilled Medical Personnel

The shortage of competent and qualified healthcare personnel is one of the reasons that is expected to restrict the growth of the small molecule API market. The market’s expansion is also expected to be hampered by the high price of small molecule API, a lack of pathologists, a lack of a compensation scheme, and a large initial investment. In the field of interventional oncology, equipment and techniques are constantly being refined to increase their accuracy and specificity. However, only full-time professionals can attain and keep excellent standards for a method like interventional oncology.

Manufacturer Outlook

Based on the Manufacturer, the Synthetic Small Molecule API Market segmented into In-house and Outsourced. The outsourced segment witnessed a significant revenue share in the synthetic small molecule API market in 2021. due to the growing shift of manufacturing firms toward contract research and development organizations for the commercial production of API during the forecast period. For instance, Curia, a CDMO, spent around USD millions in 2021 to increase the facility’s commercial manufacturing capability in Rensselaer, New York.

Application Outlook

On the basis of Application, the Synthetic Small Molecule API Market is divided into Cardiology, Oncology, CNS and Neurology, Orthopedic, Endocrinology, Pulmonology, Gastroenterology, Nephrology, Ophthalmology, and Others. The CNS and neurology segment recorded a substantial revenue share in the synthetic small molecule API market in 2021. The majority of medicines that target the central nervous system are small molecules. The majority enter the brain primarily through transcellular diffusion, a solid objects method, however, a few, including L-dopa, utilize transport mechanisms.

Regional Outlook

Region-wise, the Synthetic Small Molecule API Market is analyzed across North America, Europe, Asia Pacific, and LAMEA. The Asia Pacific segment garnered a promising revenue share in the synthetic small molecule API market in 2021. It is due to the government’s increasing assistance through supportive programs, as well as the rising interest of players in the region’s product development.

The market research report covers the analysis of key stake holders of the market. Key companies profiled in the report include Merck & Co., Inc., Viatris, Inc., Cipla Limited, Teva Pharmaceuticals Industries Ltd., Sun Pharmaceuticals Industries Ltd., AbbVie, Inc., Bristol Myers Squibb Company, Boehringer Ingelheim International GmbH, Aurobindo Pharma Limited and Albermale Corporation.

Scope of the Study

Market Segments covered in the Report:

By Manufacturer

• In-house

• Outsourced

By Application

• Cardiology

• Oncology

• CNS & Neurology

• Endocrinology

• Orthopedic

• Gastroenterology

• Pulmonology

• Nephrology

• Ophthalmology

• Others

By Geography

• North America

o US

o Canada

o Mexico

o Rest of North America

• Europe

o Germany

o UK

o France

o Russia

o Spain

o Italy

o Rest of Europe

• Asia Pacific

o China

o Japan

o India

o South Korea

o Singapore

o Malaysia

o Rest of Asia Pacific

• LAMEA

o Brazil

o Argentina

o UAE

o Saudi Arabia

o South Africa

o Nigeria

o Rest of LAMEA

Companies Profiled

• Merck & Co., Inc.

• Viatris, Inc.

• Cipla Limited

• Teva Pharmaceuticals Industries Ltd.

• Sun Pharmaceuticals Industries Ltd.

• AbbVie, Inc.

• Bristol Myers Squibb Company

• Boehringer Ingelheim International GmbH

• Aurobindo Pharma Limited

• Albermale Corporation

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