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Antibody Drugs: Technologies and Global Markets

Antibody Drugs: Technologies and Global Markets

  • September 2017
  • 115 pages
  • ID: 801344

Summary

Table of Contents

• The global market for antibody drugs reached $80.8 billion in 2016. The market should reach $114.6 billion by 2022 increasing from $84.5 billion in 2017, at a compound annual growth rate (CAGR) of 6.3% from 2017 through 2022.
• The global antibody drugs market for autoimmune diseases reached $37.3 billion in 2016. The market should reach $48.1 billion by 2022 increasing from $37.5 billion in 2017, at a CAGR of 5.1% from 2017 through 2022.
• The global antibody drugs market for lymphoma reached $37.3 billion in 2016. The market should reach $48.1 billion by 2022 increasing from $37.5 billion in 2017, at a CAGR of 5.1% from 2017 through 2022.
 
Chapter 1: Introduction
Study Goals and Objectives
Monoclonal antibodies are a type of bioengineered protein drugs. These drugs are widely used in the treatment of a variety of chronic diseases such as cancer; autoimmune diseases such as multiple sclerosis; rheumatoid arthritis; cardiovascular diseases; and other diseases such as asthma, osteoporosis, etc. BCC Research’s goal in conducting this study is to provide an overview of the current and future global market for antibody drug products.

This report explores the present and future strategies of the companies in the antibody drug product market, which includes murine mAbs, chimeric mAbs, human mAbs and humanized mAbs. The holdups and the needs of the market are discussed in this report. The classifications, comparisons and usage of these products are also portrayed in this report.

A detailed analysis of the antibody drug product industry structure has been conducted. Revenues are broken down by region. Sales figures are estimated for the five-year period of 2017 through 2022.

Applications for antibody drug products are also discussed. The report also covers significant patents and their allotments in each product category.

Reasons for Doing This Study
The antibody drug industry is one of the fast -growing industries in the pharmaceutical sector. A reason for this is that these drugs have fewer side effects than chemical drugs. Various biopharmaceutical companies are making their way into the antibody protein drug market. Manufacturing companies are focusing on the production of protein drugs. Antibody drug products have become important part of the biomedical industry.

The pharmaceutical industry is undergoing a change from chemical drugs to protein drugs due to their high specificity, enhanced efficacy, affinity, solubility and low toxicity. R&D spending, increasing competition and evolving technologies are providing a new direction to the market. This study looks at the systems affected by these trends.

Companies’ acquisition strategies and collaborative agreements are also covered in this report. This study also discusses the strength and weaknesses of each type of monoclonal antibody in light of the new technologies, growing competition and changing customer needs.

Scope of Report
This study offers a global view of the antibody drugs used in the pharmaceutical and biopharmaceutical markets. This report analyzes and assesses therapeutic applications of monoclonal antibodies (mAbs) in human medicine, including the combination of mAbs when they are attached to cytotoxic agents such as antibody drug conjugates.

BCC Research analyzes and makes projections for each market and its applications, the regulatory environment, new products and technological advances. Also included in the report are relevant patent analysis and profiles of leading companies in the antibody drug industry, such as AbbVie Inc., Amgen Inc., Biogen Inc., Johnson & Johnson Inc., Merck KGaA, Novartis AG, F. Hoffmann-La Roche Ltd. and Merck & Co.

The report covers the major markets of the U.S. and Europe, as well as emerging markets in India, China, Japan, Korea, Taiwan, Africa, Australia, New Zealand, Canada, etc.

Monoclonal antibodies are protein-based therapies/drugs that are finding use in the treatment of number of chronic diseases. This report focuses on the global market for antibody drug products and provides an updated review on their applications in various disease sectors. The overall market for antibody drug products includes four main areas of applications: autoimmune diseases; solid tumors; lymphoma and leukemia; and other diseases such as asthma, osteoporosis and cardiovascular diseases.

The report covers technology trends, including the human anti-mouse antibody (HAMA) problem caused by murine antibodies and how it was resolved by replacing murine antibodies with chimeric, human and humanized antibodies.

Excluded from this report are polyclonal antibodies; screening kits; and diagnostic uses of mAbs. Also excluded are research applications of mAbs and therapeutic antibodies for veterinary use.

Information Sources
Many companies were surveyed to obtain data for this study, including were manufacturers and end users of antibody drug products. Data was gathered from various industry sources. BCC Research spoke with industry officials and consulted newsletters, company literature, product literature, technical articles, journals, indexes and abstracts. Exhaustive investigations of databases by key terminology were conducted. In addition, data were compiled from current financial, trade and government sources.

Methodology
Both primary and secondary research methodologies were used in preparing this study. BCC Research conducted a comprehensive search of literature, which included technical newsletters, journals and other sources. Data were collected through interviews and correspondence with manufacturers and users of antibody drugs. Projections were based on estimates such as the current number of end users, potential end users, mergers and acquisitions, and market trends.

Geographic Breakdown
In this report, the geographic regions considered for market analysis include, and only include:

The U.S.

Europe
• All countries

Emerging markets
• China
• India
• Japan
• Korea
• Taiwan
• Africa
• Australia
• New Zealand
• Canada

Antibody Drugs, by Type
Murine mAbs
Chimeric mAbs
Human mAbs
Humanized mAbs

Antibody Drugs, by Application
Autoimmune diseases
Solid tumor
Lymphomas and leukemia
Others (asthma, osteoporosis, cardiovascular diseases)

Chapter 2: Summary and Highlights 
Antibody drugs are created through the use of modern scientific techniques such as genetic engineering and recombinant deoxyribonucleic acid (DNA) technology. They are produced by living cells and organisms such as Escherichia coli (E. coli), yeast, mammalian cells, etc. 

These protein drugs have gained in significance due to the increase in the number of chronic diseases such as asthma, multiple sclerosis and arthritis, and fatal diseases such as cancer and cardiovascular diseases. The antibody drug industry has grown globally due to its pivotal role in the treatment of life-threatening diseases. 
 
This report analyzes and assesses the therapeutic applications of antibodies such as mAbs in human medicine, including the combination of mAbs when they are attached to cytotoxic agent s, such as antibody drug conjugates. 
 
Genetic engineering technology has made it possible to produce these protein molecules with modified features. Owing to its high specificity and low immunogenicity, protein therapeutics is widely used to treat various life-threatening diseases such as cancer, diabetes and multiple sclerosis. Increasing R&D , increasingly sedentary lifestyles, increasing incidence of various diseases and the growing population of baby-boomers are the driving forces for the monoclonal antibody market. 
 
Leading manufacturers of mAbs include F. Hoffmann -La Roche Ltd., Johnson & Johnson Inc., Novartis 
AG, Biogen Inc., Amgen Inc., Merck KGaA, Seattle Genetics Inc. and Abb V ie Inc. More and more novel antibody drugs are being investigated and developed due to advances in technology. 

Approaches such as the development of antibody drug conjugates and bi -specific antibodies that attack the proteins present inside a cancerous cell are the present-day outlook of R&D of therapies. These therapies suppress the further progression of diseases such as arthritis, multiple sclerosis, hepatitis, Crohn’s 
 
The market for antibody drugs is divided into four types of diseases: autoimmune diseases, solid tumors, lymphoma and leukemia and other diseases such as asthma, rheumatoid arthritis and osteoporosis. 
 
In 2016, antibody drugs had the largest share of the market in autoimmune diseases with approximately 46.1%e and shares of the markets for solid tumors, lymphoma and leukemia, and other diseases of 24.2%, 13.2% and 16.5%, respectively. When BCC Research looked at the 2013 markets in its previous report on this subject, those market shares were 44.1%, 27.7%, 10.4% and 17.8%, respectively.

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