1 Table of Contents 2
1.1 List of Tables 6
1.2 List of Figures 6

2 Introduction 7
2.1 What Is This Report About? 7
2.2 Knee Reconstruction Market Segmentation 7
2.3 Definitions of Markets Covered in the Report 8

3 Knee Reconstruction Market, United States 9
3.1 Knee Reconstruction Market, United States, Revenue ($m), 2015-2025 9
3.1.1 Partial Knee Replacement Market, United States, Revenue ($m), by Segment, 2015-2025 11
3.1.2 Primary Knee Replacement Market, United States, Revenue ($m), by Segment, 2015-2025 13
3.2 Knee Reconstruction Market, United States, Volume (Units), 2015-2025 15
3.2.1 Partial Knee Replacement Market, United States, Volume (Units), by Segment, 2015-2025 17
3.2.2 Primary Knee Replacement Market, United States, Volume (Units), by Segment, 2015-2025 19
3.3 Knee Reconstruction Market, United States, Average Price ($), 2015-2025 21
3.4 Knee Reconstruction Market, United States, Distribution Share by Revenue ($m), 2017 23
3.5 Knee Reconstruction Market, United States, Company Share by Revenue ($m), 2017 24

4 Overview of Key Companies in United States, Knee Reconstruction Market 26
4.1 Zimmer Biomet Holdings Inc 26
4.1.1 Company Overview 26
4.2 DePuy Synthes Inc 26
4.2.1 Company Overview 26
4.3 Stryker Corp 26
4.3.1 Company Overview 26
4.4 Exactech Inc 26
4.4.1 Company Overview 26
4.5 Smith & Nephew Plc 27
4.5.1 Company Overview 27
4.6 MicroPort Scientific Corp 27
4.6.1 Company Overview 27

5 Knee Reconstruction Market Pipeline Products 28

6 Financial Deals Landscape 29
6.1 Equity Offerings 29
6.1.1 Amedica Files Registration Statement for Rights Offering of Units for up to USD11.4 Million 29
6.1.2 ConforMIS Prices USD20 Million in Public Offering of Shares 31
6.2 Private Equity 33
6.2.1 TPG Capital Amends Agreement to Acquire Exactech 33
6.2.2 JANA Partners Denies Rumor to Acquire Certain Stake in Zimmer Biomet 35
6.3 Venture Financing 36
6.3.1 Active Implants Raises USD3.3 Million in Venture Financing 36

7 Recent Developments 37
7.1 Corporate Communications 37
7.1.1 May 14, 2018: OMNIlife science Appoints Rick Epstein as Chief Executive Officer 37
7.1.2 Apr 30, 2018: HSS Surgeon Michael L. Parks, MD, Named President of Orthopaedic Research and Education Foundation 37
7.1.3 Apr 05, 2018: ADAPT Pharma Welcomes Surgeon General Naloxone Advisory 38
7.1.4 Mar 19, 2018: Zimmer Biomet Appoints Coleman N. Lannum as Senior Vice President of Investor Relations 39
7.1.5 Mar 13, 2018: Orthofix Announces Appointment of John Sicard to Board of Directors 39
7.1.6 Mar 05, 2018: Orthopaedic Industry Veteran Jeffrey R. Binder Joins Bill Petty, MD, as Co-Executive Chairman of Exactech; Daniel Hann Joins Exactech as Sr. Vice President of Business Development 39
7.1.7 Mar 03, 2018: Arthrex Announces New Vice President of Strategic Development 40
7.1.8 Feb 20, 2018: Onconova Announces Presentation on its Acute Myeloid Leukemia Drug Candidate ON-150030 at 2018 American Chemical Society National Meeting and Expo 40
7.1.9 Dec 19, 2017: Zimmer Biomet Announces Appointment of Bryan C. Hanson as President and Chief Executive Officer 41
7.1.10 Dec 12, 2017: Stryker announces Mr. Howard E. Cox, Jr. will retire from Board of Directors 41
7.1.11 Dec 08, 2017: Micron Solutions Designates Mr. E. P. Marinos as a Director Emeritus and Appoints Mr. Andrei Soran to its Board of Directors 42
7.1.12 Sep 26, 2017: Pharming Group and HAEi International Patient Organization announce partnership with Inceptua Medicines Access for “HAEi Global Access Program” 43
7.1.13 Sep 06, 2017: GE Healthcare: Untangling the wires using MRI research to help understand the brain 44
7.1.14 Aug 02, 2017: Stryker announces election of new Director, Mary K. Brainerd 45
7.1.15 Jul 24, 2017: Micron Solutions Appoints Rodd E. Friedman to its Board of Directors 46
7.1.16 Jul 11, 2017: Zimmer Biomet Announces Leadership Transition 46
7.1.17 Jul 11, 2017: ConforMIS Names Dan Krupp Senior Vice President U.S. Sales 47
7.2 Financial Announcements 47
7.2.1 May 15, 2018: Micron Solutions Reports 2018 First Quarter Results 47
7.2.2 May 02, 2018: Conformis Reports First Quarter 2018 Financial Results 48
7.2.3 Apr 30, 2018: Orthofix Announces First Quarter 2018 Financial Results 49
7.2.4 Apr 26, 2018: Zimmer Biomet Reports First Quarter 2018 Financial Results 50
7.2.5 Apr 26, 2018: Stryker reports first quarter 2018 operating results 50
7.2.6 Mar 26, 2018: Micron Solutions Reports 2017 Fourth Quarter and Year End Results 51
7.2.7 Feb 26, 2018: Orthofix International Reports Fourth Quarter And Fiscal 2017 Financial Results 52
7.2.8 Feb 22, 2018: Can Fite Announces the Submission of Safety Reports for Namodenoson to FDA and other Regulatory Authorities 53
7.2.9 Feb 07, 2018: ConforMIS Reports Fourth Quarter and the Year Ended 2017 Financial Results; Reiterates 2018 Financial Guidance 55
7.2.10 Jan 30, 2018: Zimmer Biomet Announces Fourth Quarter and Full-Year 2017 Results 56
7.2.11 Jan 30, 2018: Stryker reports 2017 results and 2018 outlook 57
7.2.12 Jan 09, 2018: Stryker provides 2017 preliminary net sales results 58
7.2.13 Jan 09, 2018: Orthofix Announces Preliminary 2017 Fourth Quarter and Full Year Net Sales Results 59
7.2.14 Jan 08, 2018: ConforMIS Reports Preliminary Fourth Quarter and Year-End 2017 Revenue Results; Provides 2018 Financial Guidance 60
7.2.15 Nov 13, 2017: Micron Solutions Reports 2017 Third Quarter Results 61
7.2.16 Nov 01, 2017: ConforMIS Reports Third Quarter 2017 Financial Results 62
7.2.17 Nov 01, 2017: Zimmer Biomet Reports Third Quarter 2017 Financial Results 62
7.2.18 Oct 30, 2017: Orthofix International Reports Third Quarter 2017 Financial Results 63
7.2.19 Oct 30, 2017: Exactech Q3 Revenue $61.4 Million 64
7.2.20 Oct 26, 2017: Stryker reports third quarter 2017 results 64
7.2.21 Oct 06, 2017: Bruker Introduces Fungiplex Candida Assay into European Clinical Microbiology Markets 65
7.2.22 Oct 06, 2017: Integra LifeSciences launches Revize Collagen Matrix for Plastic and Reconstructive Surgery 68
7.2.23 Sep 26, 2017: Psychemedics Announces Addition of FDA-Cleared Benzodiazepines Hair Test 68
7.2.24 Sep 26, 2017: Moleculin Announces FDA Approval of Annamycin IND 70
7.2.25 Sep 22, 2017: Amedica Releases First and Second Quarter 2017 Preliminary Unaudited Earnings Report and Business Update 71
7.2.26 Sep 07, 2017: MannKind Responds to Hurricane Harvey Devastation with Afrezza Donation 72
7.2.27 Aug 11, 2017: Micron Solutions Reports 2017 Second Quarter Results 74
7.2.28 Aug 07, 2017: Orthofix International Reports Second Quarter 2017 Financial Results 75
7.2.29 Aug 03, 2017: ConforMIS Reports Second Quarter 2017 Financial Results and Updates Fiscal Year 2017 Guidance 76
7.2.30 Jul 27, 2017: Zimmer Biomet Reports Second Quarter 2017 Financial Results 77
7.2.31 Jul 27, 2017: Stryker reports second quarter 2017 results 77
7.2.32 Jul 27, 2017: Exactech Q2 Revenue $67.3 Million On Continuing Strong Extremities Revenue 78
7.2.33 Jul 11, 2017: Zimmer Biomet Reports Certain Preliminary Second Quarter 2017 Results 79
7.2.34 Jun 20, 2017: IsoRay Announces Study Published in The International Journal of Radiation Oncology, Biology, Physics entitled, "Clinical Outcomes of Large Brain Metastases Treated with Neurosurgical Resection and Intraoperative Cesium-131 Brachytherapy: Results of 80
7.2.35 Jun 08, 2017: Amedica Releases 2016 Preliminary Earnings Report and Business Update 81
7.3 Government and Public Interest 83
7.3.1 Mar 09, 2018: HSS Study Finds Consensus Needed for Joint Replacement Performance Measurement 83
7.3.2 Mar 06, 2018: Stem cell centers on the rise, claim high efficacy for treatment of knee osteoarthritis despite lack of evidence 83
7.3.3 Mar 01, 2018: Multimodal Therapy Reduces the Use of Opioids After Surgery 84
7.3.4 Aug 29, 2017: ivWatch Awarded New Innovative Technology Contract From Vizient 85
7.3.5 Jul 11, 2017: Prosthetic knee type may determine cost of care for amputees 86
7.4 Legal And Regulatory 87
7.4.1 May 16, 2018: Zimmer Biomet Statement on Warsaw North Campus FDA Inspection 87
7.4.2 Apr 12, 2018: Sonova Showcases Expanded Product Portfolio at AAA 2018 87
7.4.3 Feb 22, 2018: GTx Phase 2 Enobosarm Clinical Trial Results in Stress Urinary Incontinence Accepted for Podium Presentation at SUFU 89
7.4.4 Dec 01, 2017: Amedica Receives Positive Nasdaq Listing Decision 89
7.4.5 Aug 30, 2017: Medovex Corporation to Present at the 19th Annual Rodman & Renshaw Global Investment Conference 90
7.4.6 Aug 09, 2017: Novadaq Receives Court Approval for Arrangement With Stryker 90
7.4.7 Jun 14, 2017: Glenmark Pharmaceuticals receives tentative ANDA approval for Saxagliptin Tablets, 2.5 mg and 5 mg 91
7.4.8 Jun 13, 2017: Zimmer Biomet Holdings Announces Resolution of FDA Warning Letter Related to Its Zhejiang, China Manufacturing Facility 91
7.5 Other Significant Developments 91
7.5.1 May 08, 2018: Amedica Provides Update on its Clinical Studies 91
7.5.2 Apr 26, 2018: Episurf Medical enters into distribution agreement in Hong Kong and establishes subsidiary in the US 92
7.5.3 Dec 06, 2017: Advanced, Minimally Invasive Hip and Knee Replacement Procedures Offered at Wilcox Medical Center 92
7.5.4 Nov 21, 2017: Littleton Adventist to offer robotic technology for knee replacements 93
7.5.5 Nov 02, 2017: ZS-9 (sodium zirconium cyclosilicate) Phase III long-term safety and efficacy data presented at ASN Kidney Week 2017 93
7.5.6 Oct 04, 2017: Zimmer Biomet Provides Update on Manufacturing Facilities in Guaynabo and Ponce, Puerto Rico 94
7.6 Product News 94
7.6.1 Mar 06, 2018: Exactech Knee System, Ankle, Shoulder Stem, Hip Stem and Computer-Assisted Surgery Technology Headline at Booth 5023, AAOS 2018 Annual Meeting 94
7.6.2 Mar 06, 2018: Neurocognitive Impairment Linked to Worse Outcomes After Total Joint Replacement 95
7.6.3 Oct 19, 2017: MicroPort Orthopedics Announces Industry Symposium at American Association of Hip and Knee Surgeons 96
7.6.4 Oct 16, 2017: Leader of Johnson & Johnson 3D Printing Center of Excellence Outlines Advantages of Customized Knee Implants 96
7.6.5 Sep 25, 2017: Bone Marrow Concentrate Improves Joint Transplants 97
7.6.6 Aug 11, 2017: Bonovo participated in the Chinese Medical Association of neurosurgery branch of the 16th academic conference 98
7.6.7 Aug 05, 2017: Bonovo participated in the first session of the Great Wall Orthopedic Forum, the 14th Beijing Orthopedic Association (BOA) and the first Beijing - Shanghai Orthopedic Summit meeting 98
7.6.8 Jun 29, 2017: Exactech Introduces New Computer-Assisted Software Application for Simplified Guidance in Total Knee Replacement 98
7.6.9 Jun 22, 2017: Exactech Expands Presence in Japan with Newly Approved Shoulder, Knee and Hip Replacement Systems 99
7.7 Strategy And Business Planning 99
7.7.1 Dec 11, 2017: Anthera Pharmaceuticals Announces Positive Outcome of Interim Futility Analysis in the Phase 3 RESULT Clinical Study of Sollpura 99
7.7.2 Nov 09, 2017: Arthrex Announces Plans for Expansion of Global Headquarters 99
7.7.3 Oct 16, 2017: Arthrex Announces Plans for New Surgical Device Manufacturing Facility 100

8 Appendix 101
8.1 Research Methodology 102
8.1.1 Coverage 102
8.1.2 Secondary Research 102
8.1.3 Primary Research 103
8.1.4 Market Modeling and Forecasting 104
8.1.5 Company Share Analysis 105
8.1.6 Distribution Share Analysis 106
8.1.7 Benchmarking 106
8.2 GlobalData Consulting 106
8.3 Contact Us 107
8.4 Disclaimer 107

1.1 List of Tables
Table 1: Knee Reconstruction Market, United States, Revenue ($m), USD Constant, 2015-2020 10
Table 2: Knee Reconstruction Market, United States, Revenue ($m), USD Constant, 2021-2025 10
Table 3: Partial Knee Replacement Market, United States, Revenue ($m), USD Constant, 2015-2020 12
Table 4: Partial Knee Replacement Market, United States, Revenue ($m), USD Constant, 2021-2025 12
Table 5: Primary Knee Replacement Market, United States, Revenue ($m), USD Constant, 2015-2020 14
Table 6: Primary Knee Replacement Market, United States, Revenue ($m), USD Constant, 2021-2025 14
Table 7: Knee Reconstruction Market, United States, Volume (Units), 2015-2020 16
Table 8: Knee Reconstruction Market, United States, Volume (Units), 2021-2025 16
Table 9: Partial Knee Replacement Market, United States, Volume (Units), 2015-2020 18
Table 10: Partial Knee Replacement Market, United States, Volume (Units), 2021-2025 18
Table 11: Primary Knee Replacement Market, United States, Volume (Units), 2015-2020 20
Table 12: Primary Knee Replacement Market, United States, Volume (Units), 2021-2025 20
Table 13: Knee Reconstruction Market, United States, Average Price ($), 2015-2020 21
Table 14: Knee Reconstruction Market, United States, Average Price ($), 2021-2025 22
Table 15: Knee Reconstruction Market, United States, Distribution Share by Revenue ($m), USD Constant, 2017 23
Table 16: Knee Reconstruction Market, United States, Company Share by Revenue ($m), USD Constant, 2017 25
Table 17: Knee Reconstruction Market Pipeline Products 28
Table 18: Amedica Files Registration Statement for Rights Offering of Units for up to USD11.4 Million 29
Table 19: ConforMIS Prices USD20 Million in Public Offering of Shares 31
Table 20: TPG Capital Amends Agreement to Acquire Exactech 33
Table 21: JANA Partners Denies Rumor to Acquire Certain Stake in Zimmer Biomet 35
Table 22: Active Implants Raises USD3.3 Million in Venture Financing 36
Table 23: Total Number of Primary Research Participants, Orthopedic Devices Market, by Country 104

1.2 List of Figures
Figure 1: Knee Reconstruction Market, United States, Revenue ($m), USD Constant, 2015-2025 9
Figure 2: Partial Knee Replacement Market, United States, Revenue ($m), USD Constant, 2015-2025 11
Figure 3: Primary Knee Replacement Market, United States, Revenue ($m), USD Constant, 2015-2025 13
Figure 4: Knee Reconstruction Market, United States, Volume (Units), 2015-2025 15
Figure 5: Partial Knee Replacement Market, United States, Volume (Units), 2015-2025 17
Figure 6: Primary Knee Replacement Market, United States, Volume (Units), 2015-2025 19
Figure 7: Knee Reconstruction Market, United States, Company Share (%) 2017 24

Companies Mentioned
- Zimmer Biomet Holdings Inc
- DePuy Synthes Inc
- Stryker Corp
- Exactech Inc
- Smith & Nephew Plc
- MicroPort Scientific Corp