1 Table of Contents

1 Table of Contents 2
1.1 List of Tables 3
1.2 List of Figures 3

2 Executive Summary 5
2.1 Biologics and mAbs Growing in Prominence in Asthma Treatment 5
2.2 Market Landscape to Grow in Diversity over Coming Years 5
2.3 Cytokine and Kinase Targeted Small Molecules and mAbs Dominate First-in-Class Innovation 5
2.4 Deals Landscape Offers Significant Investment Opportunities for First-in-Class Products 5

3 The Case for Innovation in the Asthma Market 6
3.1 Growing Number of Opportunities for Biologic Products 7
3.2 Diversification of Molecular Targets 7
3.3 Innovative First-in-Class Product Developments Remain Attractive 7
3.4 Changes in Clinical and Commercial Environment to be More Favorable to Products Targeting Niche Patient Populations and Indications 8
3.5 Sustained Innovation 8
3.6 GBI Research Report Guidance 9

4 Clinical and Commercial Landscape 10
4.1 Disease Overview 10
4.2 Epidemiology 10
4.3 Etiology 11
4.4 Pathophysiology 11
4.5 Disease Symptoms 12
4.6 Diagnosis 12
4.6.1 Disease Prgnosis 13
4.6.2 Assessment of Disease Severity 13
4.7 Treatment 15
4.7.1 Quick-Relief Medication 15
4.7.2 ICSs for the Maintenance Treatment of Asthma 16
4.7.3 ICS/LABA Combination Therapy for the Maintenance Treatment of Asthma 16
4.7.4 Add-on Therapies to ICS or ICS/LABA Therapies for the Maintenance Treatment of Asthma 17
4.7.5 Treatment Algorithm 18
4.8 Overview of Marketed Products 21
4.9 Current Unmet Need in the Asthma Market 22

5 Assessment of Pipeline Product Innovation 23
5.1 Asthma Pipeline by Molecule Type, Stage of Development and Molecular Target 23
5.2 Comparative Distribution of Programs between the Asthma Market and Pipeline by Molecular Target 29
5.3 First-in-Class Pipeline Programs Targeting Novel Molecular Targets 29

6 Signaling Network and Innovation Alignment 33
6.1 Complexity of Signaling Networks in Asthma 33
6.2 First-in-Class Matrix Assessment 33

7 First-in-Class Target Evaluation 36
7.1 Pipeline Programs Targeting Calcium Release Activated Calcium Channel Protein 1 36
7.1.1 Overview of Pipeline Programs Targeting Calcium Release Activated Calcium Channel Protein 1 37
7.2 Pipeline Programs Targeting CXC Chemokine Receptors 37
7.2.1 Overview of Pipeline Programs Targeting CXC Chemokine Receptors 38
7.3 Pipeline Programs Targeting Spleen Tyrosine Kinase 38
7.3.1 Overview of Pipeline Programs Targeting Spleen Tyrosine Kinase 39
7.4 Pipeline Programs Targeting Compliment Component 5a Receptor 1 40
7.4.1 Overview of Pipeline Programs Targeting Compliment Component 5a Receptor 1 40
7.5 Pipeline Programs Targeting Interleukin-33 41
7.5.1 Overview of Pipeline Programs Targeting Interleukin-33 41
7.6 Pipeline Programs Targeting CC Chemokine Receptor Type 3 42
7.6.1 Overview of Pipeline Programs Targeting CC Chemokine Receptor Type 3 42
7.7 Pipeline Programs Targeting Antigen Presenting Glycoprotein CD1d 43
7.7.1 Overview of Pipeline Programs Targeting Antigen Presenting Glycoprotein CD1d 44
7.8 Pipeline Programs Targeting Interleukin 4 Receptor Subunit Alpha 44
7.8.1 Overview of Pipeline Programs Targeting Interleukin 4 Receptor Subunit Alpha 45
7.9 Conclusion 45

8 Deals and Strategic Consolidations 46
8.1 Industry-Wide First-in-Class Deals 46
8.2 Asthma Deals Landscape 47
8.3 Licensing Deals 48
8.3.1 Molecule Type 50
8.3.2 Molecular Target 50
8.4 Co-development Deals 52
8.4.1 Molecule Type 53
8.4.2 Molecular Target 53
8.5 Pipeline Products without Prior Licensing or Co-Development Deal Involvement 55

9 Appendix 57
9.1 References 57
9.2 Abbreviations 59
9.3 Primary Research 60
9.4 Contact Us 61
9.5 Disclaimer 61

1.1 List of Tables
Table 1: Asthma Therapeutics Market, Global, Classification of Asthma Severity in Children Aged 0-4 14
Table 2: Asthma Therapeutics Market, Global, Classification of Asthma Severity in Children Aged 5-11 14
Table 3: Asthma Therapeutics Market, Global, Classification of Asthma Severity in Youths ?12 Years of Age and Adults 15
Table 4: Asthma Therapeutics Market, Global, Management of Chronic Asthma 19
Table 5: Asthma Therapeutics Market, Global, Management of Chronic Asthma 20
Table 6: Asthma Therapeutics Market, Global, Management of Acute Asthma 21
Table 7: Asthma Therapeutics Market, Global, Data for Calcium Release Activated Calcium Channel Protein 1 as a Molecular Target 37
Table 8: Asthma Therapeutics Market, Global, Data for CXC Chemokine Receptors as Molecular Targets, 2016 38
Table 9: Asthma Therapeutics Market, Global, Data for Spleen Tyrosine Kinase as a Molecular Target, 2016 39
Table 10:Asthma Therapeutics Market, Global, Data for Compliment Component 5a Receptor 1 as a Molecular Target, 2016 40
Table 11: Asthma Therapeutics Market, Global, Data for Interleukin-33 as a Molecular Target, 2016 41
Table 12:Asthma Therapeutics Market, Global, Data for CC Chemokine Receptor Type-3 as a Molecular Target, 2016 42
Table 13:Asthma Therapeutics Market, Global, Data for Antigen Presenting Glycoprotein CD1d as a Molecular Target, 2016 43
Table 14: Asthma Therapeutics Market, Global, Data for Interleukin 4 Receptor Subunit Alpha as a Molecular Target, 2016 45

1.2 List of Figures
Figure 1: Overall Pharmaceutical Industry, Innovation Trends in Product Approvals, Number of Product Approvals by FDA and Five-Year Moving Average of Products Approvals (%), 1987-2014 6
Figure 2:Overall Pharmaceutical Industry, First-in-Class and Non-First-in-Class Products, Sales Performance After Marketing Approval, 2006-2013 ($m) 7
Figure 3:Asthma Therapeutics Market, Global, Marketed Product Overview, 2016 22
Figure 4:Pharmaceutical Market, Global, Developmental Pipeline Overview, 2016 23
Figure 5: Asthma Therapeutics Market, Global, Pipeline by Stage of Development and Molecule Type, 2016 24
Figure 6: Asthma Therapeutics Market, Global, Pipeline by Molecular Target and Cytokine/Cytokine Receptor Subcategory, 2016 25
Figure 7: Asthma Therapeutics Market, Global, Pipeline by Molecular Target Subcategories, 2016 28
Figure 8: Asthma Therapeutics Market, Global, Molecular Target Category Comparison, Pipeline and Marketed Products, 2016 29
Figure 9: Asthma Therapeutics Market, Global, Molecular Target Family Comparison, Pipeline First-in-Class and Established Molecular Targets, 2016 30
Figure 10: Asthma Therapeutics Market, Global, Percentage of First-in-Class Products in Pipeline by Stage of Development (%), 2016 31
Figure 11: Asthma Therapeutics Market, Global, Percentage of First-in-Class Products in Pipeline by Molecular Target Family (%), 2016 31
Figure 12: Asthma Therapeutics Market, Global, First-in-Class Molecular Targets in Pipeline Development, 2016 32
Figure 13: Asthma Therapeutics Market, Global, First-in-Class Molecular Target Analysis Matrix, 2016 34
Figure 14: Asthma Therapeutics Market, Global, Pipeline Programs Targeting Calcium Release Activated Calcium Channel Protein 1, 2016 37
Figure 15: Asthma Therapeutics Market, Global, Pipeline Programs Targeting CXC Chemokine Receptors, 2016 38
Figure 16: Asthma Therapeutics Market, Global, Pipeline Programs Targeting Spleen Tyrosine Kinase, 2016 40
Figure 17: Asthma Therapeutics Market, Global, Pipeline Programs Targeting Compliment Component 5a Receptor 1, 2016 41
Figure 18: Asthma Therapeutics Market, Global, Pipeline Programs Targeting Interleukin-33, 2016 42
Figure 19: Asthma Therapeutics Market, Global, Pipeline Programs Targeting CC Chemokine Receptor Type-3, 2016 43
Figure 20: Asthma Therapeutics Market, Global, Pipeline Programs Targeting Antigen Presenting Glycoprotein CD1d, 2016 44
Figure 21: Asthma Therapeutics Market, Global, Pipeline Programs Targeting Interleukin 4 Receptor Subunit Alpha, 2016 45
Figure 22: Pharmaceutical Market, Global, Industry-Wide Deals by Stage of Development, 2006-2014 46
Figure 23: Pharmaceutical Market, Global, Industry Licensing Deal Values by Stage of Development, 2006-2014 47
Figure 24: Asthma Therapeutics Market, Global, Licensing Deals by Region and Value, 2006-2016 49
Figure 25: Asthma Therapeutics Market, Global, Licensing Deals by Stage of Development, 2006-2016 50
Figure 26: Asthma Therapeutics Market, Global, Licensing Deals by Molecule Type, 2006-2016 50
Figure 27: Asthma Therapeutics Market, Global, Licensing Deals by Molecular Target, 2006-2016 51
Figure 28: Asthma Therapeutics Market, Global, Licensing Deals Valued Above $100m, 2006-2016 51
Figure 29: Asthma Therapeutics Market, Global, Co-Development Deals by Region and Value, 2006-2016 52
Figure 30: Asthma Therapeutics Market, Global, Co-Development Deals by Stage of Development, 2006-2016 53
Figure 31: Asthma Therapeutics Market, Global, Co-Development Deals by Molecule Type, 2006-2016 53
Figure 32: Asthma Therapeutics Market, Global, Co-Development Deals by Molecular Target, 2006-2016 54
Figure 33: Asthma Therapeutics Market, Global, Co-Development Deals Valued Above $100m, 2006-2016 54
Figure 34: Asthma Therapeutics Market, Global, First-in-class Programs in Active Development Involved in Previous Deals, 2016 55
Figure 35: Asthma Therapeutics Market, Global, First-in-class Programs in Active Development Without Recorded Prior Deal Involvement, 2016 56