I. Worldwide Market and Technology Overview
A. Introduction
1. Major Factors Affecting Market Penetration
of Microbiology Instrumentation
2. Traditional Practices
3. Technological Challenges
4. Automation: Impact on the Microbiology
Laboratory and the Patient
B. Major Specimen Types
1. Urine
2. Sterile Fluids: Blood, Serum, and CSF
3. Throat Swabs and Respiratory Secretions
4. Genital Secretions
5. Stool
6. Abscess/Wound
7. Sputum
8. Saliva
C. Test Applications
1. Microbial Identification
2. Antibiotic Susceptibility
3. Urine Screening
a. Photometry
b. Bioluminescence
c. Colorimetric Filtration
d. Enzymatic Detection
e. Optical Detection
4. Blood Cultures
D. Major Microbiology Automated and Semiautomated Systems
1. Multiple Purpose Microbiology Systems
2. Specialized Microbiology Systems
3. Molecular Diagnostic Systems
4. Immunodiagnostic Systems

E. Emerging Diagnostic Technologies
1. Molecular Diagnostics
a. DNA Sequencing
Introduction
Sequencing Methods
Autoradiography
The Human Genome Project
Sequencing Automation
Image Scanners
Fluorescent Detection
Gene Profiling
Gene Expression
Polymorphism Screening
Protein Interaction Networks
b. DNA And RNA Probe Technology
Basic Principles
Probe Preparation
The DNA Probe Test
- Sample Preparation
- Hybridization
- Separation
- Detection/Measurement
Test Formats
- Filter Hybridization
- Southern Blot
- Northern Blot
- In Situ Hybridization
- Others
Labeling Techniques
Amplification Methods
O Polymerase Chain Reaction
- Temperature Cyclers
- PCR Variations
* Immuno-PCR
* QC-PCR
* DAP-PCR
O Strand Displacement Activation
O TMA
O Ligase Chain Reaction

O Branched DNA
- Hybridization Protection Assay
O Nucleic-Acid Sequence-Based Amplification
O Self-Sustained Sequence Replicase
O Others
- Ampliprobe
- CAR
- CAS
- CPT
- Dendritic Polymer Technology
- ISO-CR
- LAT
- Probe
- RAMP
- Repair Chain Reaction
- Rolling Circles
- Sequence Independent Gene Amplification
- Sequence Initiation Reaction
- SISPA
- Solid Phase Amplification
c. Detection Technologies
Radioactive Methods
- Overview
- Major Isotopes
O P-32
O S-35
O H-3
O I-125
Non-Isotopic Methods
- Enzymatic Labels
- Chemical Labeling
O Indirect Chemical Labeling
O Direct Chemical Labeling
- Fluorescence
- Chemiluminescence
- Electrical Conductivity


d. Biochips: Genosensors, Microarrays,
and Labs-on-the-Chip
- Liquid Transportation and Mixing
- Separation
- Reaction
- Detection
2. Monoclonal Antibodies
3. Immunoassays
4. Differential Light Scattering
5. Information Technology
6. Artificial Intelligence
7. Liposomes
8. Flow Cytometry
9. Chromatography
10. Diagnostic Imaging
11. Gel Microdroplets
12. Other

II.
A. Business Environment
B. Market Structure
C. Market Size, Growth and Major Supplier Sales and Market Shares
III. Major Product Development Opportunities
IV. Design Criteria for Decentralized Testing Products
V. Alternative Market Penetration Strategies
A. Internal Development
B. Collaborative Arrangements
C. University Contracts
D. Distribution Strategies for Decentralized Testing Markets
1. Marketing Approaches
2. Product Complexity
3. Customer Preference

4. Established Suppliers
5. Emerging Suppliers
6. Major Types of Distributors
7. Market Segmentation
VII. Potential Market Entry Barriers and Risks
A. Market Maturity
B. Cost Containment
C. Competition
D. Technological Edge and Limitations
E. Patent Protection
F. Regulatory Constraints
G. Decentralized Testing Market Challenges
VIII. Competitive Assessments
- Abbott
- Affymetrix
- Agilent Technologies
- Applied Gene Technologies
- Arca bioipharma
- Beckman Coulter/Danaher
- Becton Dickinson
- Biokit
- bioMerieux
- Bio-Rad
- Biotest
- Cepheid
- CellMark Forensics/Lab Corp
- Decode Genetics
- Diadexus
- Diamedix/Erba
- DiaSorin
- Eiken Chemical
- Elitech Group
- Enzo Biochem
- Exact Sciences
- Fujirebio
- Grifols
- Hologic/Gen-Probe
- Illumina
- ID Biomedical/GSK

- Kreatech/Leica
- Li-Cor Biosciences
- Lonza
- Monogram Biosciences
- Myriad Genetics
- Ortho-Clinical Diagnostics
- Perkin Elmer/Caliper
- Proteome Sciences
- Qiagen
- Roche
- Scienion
- Sequenom
- SeraCare
- Siemens
- Sierra Molecular
- Shimadzu
- Takara Bio
- Tecan
- Thermo Fisher
- Wallac/PE
- Wako


List of Tables
Major Companies Developing or Marketing AIDS Tests
Major Companies Developing or Marketing Adenovirus Tests
Major Companies Developing or Marketing Bartonella Tests
Major Companies Developing or Marketing Campylobacter Tests
Major Companies Developing or Marketing Candida Tests
Major Companies Developing or Marketing Chlamydia Tests
Major Companies Developing or Marketing Clostridium Tests
Major Companies Developing or Marketing Coronavirus Tests
Major Companies Developing or Marketing Cryptosporidium Tests
Major Companies Developing or Marketing CMV Tests
Major Companies Developing or Marketing Echovirus Tests
Major Companies Developing or Marketing Enterovirus Tests
Major Companies Developing or Marketing EBV Tests
Major Companies Developing or Marketing Giardia Tests
Major Companies Developing or Marketing Gonorrhea Tests
Major Companies Developing or Marketing Hantavirus Tests
Major Companies Developing or Marketing Helicobacter Pylori Tests
Major Companies Developing or Marketing Hepatitis Tests
Major Companies Developing or Marketing Herpes Tests
Major Companies Developing or Marketing Influenza Tests

Major Companies Developing or Marketing Legionella Tests
Major Companies Developing or Marketing Lyme Disease Tests
Major Companies Developing or Marketing Lymphogranuloma Tests
Major Companies Developing or Marketing Malaria Tests
Major Companies Developing or Marketing Measles Tests
Major Companies Developing or Marketing Meningitis Tests
Major Companies Developing or Marketing Microsporidium Tests
Major Companies Developing or Marketing Mononucleosis Tests
Major Companies Developing or Marketing Mumps Tests
Major Companies Developing or Marketing Mycoplasma Tests
Major Companies Developing or Marketing Papilloma Virus Tests
Major Companies Developing or Marketing Parvovirus Tests
Major Companies Developing or Marketing Pneumonia Tests
Major Companies Developing or Marketing RSV Tests
Major Companies Developing or Marketing Rotavirus Tests
Major Companies Developing or Marketing Rubella Tests
Major Companies Developing or Marketing Salmonella Tests
Major Companies Developing or Marketing Septicemia Tests
Major Companies Developing or Marketing Shigella Tests
Major Companies Developing or Marketing Staphylococci Tests

Major Companies Developing or Marketing Streptococci Tests
Major Companies Developing or Marketing Syphilis Tests
Major Companies Developing or Marketing Toxoplasmosis Tests
Major Companies Developing or Marketing Trichomonas Tests
Major Companies Developing or Marketing Tuberculosis Tests
Major Companies Developing or Marketing West Nile Tests
Major Companies Developing or Marketing Yersinia Tests