1 EXECUTIVE SUMMARY 25

2 INTRODUCTION 29
2.1 KEY TAKEAWAYS 29
2.2 REPORT DESCRIPTION 29
2.3 MARKETS COVERED 31
2.4 STAKEHOLDERS 33
2.5 RESEARCH METHODOLOGY 33
2.5.1 MARKET SIZE ESTIMATION 35
2.5.2 MARKET BREAKDOWN AND DATA TRIANGULATION 37
2.5.3 SECONDARY SOURCES 38
2.5.4 PRIMARY SOURCES 38
2.5.5 KEY DATA POINTS FROM SECONDARY SOURCES 39
2.5.6 KEY DATA POINTS FROM PRIMARY SOURCES 39
2.5.7 ASSUMPTIONS 40

3 MARKET ANALYSIS 41
3.1 INTRODUCTION 41
3.2 MARKET SEGMENTATION 43
3.3 FACTORS INFLUENCING MARKET 44
3.3.1 DRIVERS AND OPPORTUNITIES 45
3.3.1.1 Mandatory toxicology testing in various industries & rise in global R&D investments 45
3.3.1.2 Increasing outsourcing trend 45
3.3.1.3 Increased funding by the public and private sector 46
3.3.1.4 Crop protection demand driven by the ongoing need to increase the efficiency of food production to feed growing global populations 47
3.3.1.5 Rapid advances in technologies 48
3.3.1.6 Increasing product failure due to safety concerns 48
3.3.2 RESTRAINTS AND THREATS 49
3.3.2.1 High cost and long duration of tests 49
3.3.2.2 High capital and technical requirements for glp certification 50
3.3.2.3 Increased funding towards repurposing 50
3.3.2.4 Opposition to animal testing 51
3.3.2.5 Limited ip protection in developing regions 51
3.4 REGULATORY AFFAIRS 52
3.4.1 INTRODUCTION 52
3.4.2 PHARMACEUTICALS 52
3.4.3 MEDICAL DEVICES 53
3.4.4 COSMETICS 57
3.4.5 CHEMICAL 58
3.4.5.1 Industrial chemical 58
3.4.5.2 Agrochemical, environmental and consumer goods 59
3.4.6 FOOD 61
3.5 MARKET SHARE ANALYSIS 62

4 TOXICOLOGY SERVICES GLOBAL MARKET, BY METHOD 64
4.1 INTRODUCTION 64
4.2 IN VIVO TOXICOLOGY 67
4.3 IN VITRO TOXICOLOGY 74
4.3.1 CELLULAR & BIOCHEMICAL 80
4.3.2 EX VIVO 83
4.3.3 IN SILICO 86

5 TOXICOLOGY SERVICES GLOBAL MARKET, BY INDUSTRY 89
5.1 INTRODUCTION 89
5.2 PHARMACEUTICAL 92
5.2.1 DISCOVERY TOXICOLOGY 96
5.2.2 PRECLINICAL TOXICOLOGY 96
5.3 MEDICAL DEVICES 98
5.4 COSMETICS 103
5.5 CHEMICAL 109
5.5.1 INDUSTRIAL CHEMICALS 115
5.5.2 AGROCHEMICALS 120
5.5.3 EVIRONMENTAL 125
5.6 OTHER INDUSTRIES 128
5.6.1 FOOD 133
5.6.2 CONSUMER GOODS 139

6 TOXICOLOGY SERVICES GLOBAL MARKET, BY ENDPOINT TESTS 142
6.1 INTRODUCTION 142
6.2 SYSTEMIC TOXICOLOGY 146
6.3 ORGAN TOXICOLOGY 149
6.4 DERMAL TOXICOLOGY 152
6.5 NEUROTOXICOLOGY 156
6.6 OCULAR TOXICOLOGY 159
6.7 GENOTOXICOLOGY 162
6.8 DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY 165
6.9 CARCINOGENICITY 168
6.10 ECOTOXICOLOGY 171

7 TOXICOLOGY SERVICES MARKET, BY REGION 174
7.1 INTRODUCTION 174
7.2 NORTH AMERICA 176
7.2.1 U.S. 189
7.2.2 OTHERS 191
7.3 EUROPE 193
7.3.1 GERMANY 205
7.3.2 FRANCE 207
7.3.3 U.K. 209
7.3.4 OTHERS 211
7.4 ASIA-PACIFIC 213
7.4.1 CHINA 225
7.4.2 INDIA 227
7.4.3 JAPAN 230
7.4.4 OTHERS 232
7.5 ROW 234
7.5.1 BRAZIL 246
7.5.2 REST OF LATIN AMERICA 248
7.5.3 MIDDLE EAST & OTHERS 251

8 COMPANY DEVELOPMENTS 254
8.1 INTRODUCTION 254
8.2 ACQUISITIONS & MERGERS 255
8.3 AGREEMENTS & PARTNERSHIPS 257
8.4 NEW SERVICE LAUNCH 259
8.5 OTHERS 261

9 MAJOR COMPANIES 272
9.1 BUREAU VERITAS 272
9.1.1 OVERVIEW 272
9.1.2 FINANCIALS 273
9.1.3 SERVICE PORTFOLIO 275
9.1.4 KEY DEVELOPMENTS 276
9.1.5 BUSINESS STRATEGY 276
9.1.6 SWOT ANALYSIS 277
9.2 CHARLES RIVER LABORATORIES 278
9.2.1 OVERVIEW 278
9.2.2 FINANCIALS 280
9.2.3 SERVICE PORTFOLIO 283
9.2.4 KEY DEVELOPMENTS 283
9.2.5 BUSINESS STRATEGY 285
9.2.6 SWOT ANALYSIS 286
9.3 EUROFINS SCIENTIFIC 287
9.3.1 OVERVIEW 287
9.3.2 FINANCIALS 289
9.3.3 SERVICE PORTFOLIO 291
9.3.4 KEY DEVELOPMENTS 292
9.3.5 BUSINESS STRATEGY 293
9.3.6 SWOT ANALYSIS 294
9.4 ENVIGO 295
9.4.1 OVERVIEW 295
9.4.2 FINANCIALS 296
9.4.3 SERVICE PORTFOLIO 296
9.4.4 KEY DEVELOPMENTS 298
9.4.5 BUSINESS STRATEGY 299
9.4.6 SWOT ANALYSIS 300
9.5 EVOTEC A.G. 301
9.5.1 OVERVIEW 301
9.5.2 FINANCIALS 303
9.5.3 SERVICE PORTFOLIO 306
9.5.4 KEY DEVELOPMENTS 308
9.5.5 BUSINESS STRATEGY 310
9.5.6 SWOT ANALYSIS 311
9.6 LABORATORY CORP. OF AMERICA HOLDINGS (LABCORP) 312
9.6.1 OVERVIEW 312
9.6.2 FINANCIALS 314
9.6.3 SERVICE PORTFOLIO 316
9.6.4 KEY DEVELOPMENTS 318
9.6.5 BUSINESS STRATEGY 318
9.6.6 SWOT ANALYSIS 319
9.7 MERCK KGAA 320
9.7.1 OVERVIEW 320
9.7.2 FINANCIALS 322
9.7.3 SERVICE PORTFOLIO 325
9.7.4 KEY DEVELOPMENTS 325
9.7.5 BUSINESS STRATEGY 325
9.7.6 SWOT ANALYSIS 326
9.8 MPI RESEARCH 327
9.8.1 OVERVIEW 327
9.8.2 FINANCIALS 328
9.8.3 SERVICE PORTFOLIO 328
9.8.4 KEY DEVELOPMENTS 329
9.8.5 BUSINESS STRATEGY 329
9.8.6 SWOT ANALYSIS 330
9.9 SGS GROUP 331
9.9.1 OVERVIEW 331
9.9.2 FINANCIALS 333
9.9.3 SERVICE PORTFOLIO 336
9.9.4 KEY DEVELOPMENTS 337
9.9.5 BUSINESS STRATEGY 337
9.9.6 SWOT ANALYSIS 338
9.10 WUXI APPTEC 339
9.10.1 OVERVIEW 339
9.10.2 FINANCIALS 340
9.10.3 SERVICE PORTFOLIO 341
9.10.4 KEY DEVELOPMENTS 342
9.10.5 BUSINESS STRATEGY 342
9.10.6 SWOT ANALYSIS 343

Companies Mentioned
• BUREAU VERITAS
• CHARLES RIVER LABORATORIES
• EUROFINS SCIENTIFIC
• ENVIGO
• EVOTEC A.G.
• LABCORP
• MERCK KGAA
• MPI RESEARCH
• SGS GROUP
• WUXI APPTEC
• LIST OF COMPANIES MENTIONED IN THE REPORT
• ABSORPTION SYSTEMS L.P
• ACCELERA S.R.L
• ADMESCOPE
• ALBANY MOLECULAR RESEARCH, INC. (AMRI)
• ALS GROUP
• ALTOGEN LABS
• AMERICAN PRECLINICAL SERVICES
• AMPLIA PHARMATEK INC.
• ANTHEM BIOSCIENCES
• APT TESTING & RESEARCH PVT. LTD. (ATR)
• AQUATOX TESTING & CONSULTING INC
• ATHENA DISCOVERY, INC
• AURIGENE
• BATTELLE MEMORIAL INSTITUTE
• BIENTA/ENAMINE LTD.
• FORMEX LLC (BIODURO)
• BIOMED PRECLINICAL SOLUTIONS
• BIONEEDS INDIA PVT LTD
• BOLDER BIOPATH, INC.
• BOZO RESEARCH CENTER
• BTS RESEARCH
• BUREAU VERITAS (MAXXAM)
• BURLESON RESEARCH TECHNOLOGIES, INC.
• CARE RESEARCH, LLC
• CHARLES RIVER LABORATORIES
• CHEMDIV, INC.
• CHEMEX ENVIRONMENTAL INTERNATIONAL LTD
• CHEMON INC.
• CHEMPARTNER
• CIDP
• CITOX LAB
• CMIC INC.
• CNBE INRS
• COGNIBRAIN
• COMPARATIVE BIOSCIENCES, INC.
• COMPUTATIONAL TOXICOLOGY SERVICES LLC
• CONCEPT LIFE SCIENCES
• CONCORD BIOSCIENCES LLC
• CONSUMER PRODUCT TESTING COMPANY
• CREAGEN BIOSCIENCES INC.
• CREATIVE ANIMODEL
• CREATIVE DYNAMICS INC. (CREATIVE BIOARRAY)
• CROWN BIOSCIENCE INC.
• CENTRE FOR TOXICOLOGY AND ENVIRONMENTAL HEALTH (CTEH )
• CXR BIOSCIENCES
• DILISYM SERVICES INC
• DSK INNOSCIENCES
• EAG LABORATORIES
• ECOTOX SERVICES INTERNATIONAL
• EMULATE INC
• ENVIGO
• ENVIRONMENTAL BIO-DETECTION PRODUCTS (EBPI)
• EUROFINS
• EVOTEC (CYPROTEX PLC., APTUIT)
• EXELGEN DISCOVERY
• EXOVA
• EXPLORA BIOLABS
• FRANUHOFER ITEM
• FERA SCIENCE LTD.
• FORTHTOX LTD
• GATEWAY PHARMACOLOGY LABORATORIES
• GENEVA LABORATORIES, INC.
• GLR LABS PVT LTD
• GREINER BIO-ONE INTERNATIONAL GMBH
• GVK BIO
• HEMOGENIX
• IDSC, LLC.
• IN SILICO TOXICOLOGY GMBH
• INA RESEARCH
• INNOVATIVE ENVIRONMENTAL SERVICES (IES) LTD
• INSPHERO A.G.
• INSTITUTE OF INDUSTRIAL ORGANIC CHEMISTRY
• INTELLISYN RD
• INTOX PVT. LTD.
• INVITEK INC.
• INVITROCUE
• ITR LABORATORIES CANADA INC.
• IUVO BIOSCIENCE
• JAI RESEARCH FOUNDATION
• JUBILANT BIOSYS
• KALY-CELL
• KEMXTREE LLC
• KRISH BIOTECH
• LABCORP (COVANCE)
• LEVEL BIOTECHNOLOGY
• LPT LABORATORY OF PHARMACOLOGY
• MB RESEARCH LABORATORIES
• MERCK KGAA (BIORELIANCE, INC.)
• MÉRIEUX NUTRISCIENCES CORPORATION
• METRION BIOSCIENCES
• MICROCHEM LABORATORY INC
• MPI RESEARCH INC
• MURIGENICS
• NAMSA INC
• NAUTILUS ENVIRONMENTAL
• NEO BIOMED SERVICES LTD
• NOBLE LIFE SCIENCES
• NOVAMASS LTD
• NUCROTECHNICS
• NUMERATE, INC.
• LOVELACE RESPIRATORY RESEARCH INSTITUTE
• PACIFIC BIOLABS
• PACIFIC ECORISK, INC.
• PARAZA PHARMA, INC.
• PBR LABORATORIES
• PHARMACELSUS GMBH
• PHARMADIRECTIONS INC
• PHARMALEGACY LABORATORIES
• PHARMARON, INC.
• PHARMASEED
• POLLUTECH GROUP OF COMPANIES INC.
• PPD
• PRADO PVT. LTD.
• PRODUCT SAFETY LABS INC
• QINGDAO TAIHONGDA CHEMICAL CO.,LTD (FORMERLY PHARMATHD)
• QPS
• RCC LABORATORIES INDIA PRIVATE LIMITED
• ROBIN GUY CONSULTING, LLC
• ROVALTAIN RESEARCH COMPANY
• SA-FORD
• SAI LIFE SCIENCES
• SBH SCIENCES
• SELCIA
• SELVITA SA
• SEQUANI LTD
• SGR ESPECIALIZADA
• SGS
• SHANGHAI MEDICILON
• SHIN NIPPON BIOMEDICAL LABORATORIES LTD. (SNBL)
• SIGNATURE DISCOVER
• SIMULATIONS PLUS, INC.
• SINCLAIR RESEARCH
• SMITHERS VISCIENT
• SOBRAN
• SRI INTERNATIONAL
• SUNDIA MEDITECH CO
• SYNGENE INTERNATIONAL
• SYNTECH RESEARCH INC
• TCG LIFESCIENCES
• TNO TRISKELION B.V.
• TOXICOLOGY SOLUTIONS
• TOXIKON CORPORATION
• TOXINDIA
• TOXSTRATEGIES INC.
• TRE ENVIRONMENTAL STRATEGIES, LLC
• TUV SUD AG
• VANTA BIOSCIENCES
• VIMTA LABS LIMITED
• VIROCLINICS BIOSCIENCES
• VIVO BIOTECH LTD
• VIVO SCIENCE
• VIVOPHARM PTY LTD
• VIVOTECNIA
• WICKHAM LABORATORIES LTD
• WUXI PHARMATECH
• XENOMETRICS LLC