1. PREFACE

1.1. Scope of the Report
1.2. Research Methodology
1.3. Chapter Outlines

2. EXECUTIVE SUMMARY

3. INTRODUCTION

3.1. Chapter Overview
3.2. Structure of the Human Brain
3.3. Global Burden of Neurological Disorders
3.4. Strategies for Drug Delivery to the Central Nervous System (CNS)
3.4.1. Invasive Techniques
3.4.1.1. Systemic Administration of Therapeutics
3.4.1.2. Direct Administration of Therapeutics
3.4.1.3. Intracerebral Devices and Implants
3.4.2. Non-Invasive Techniques / Approaches
3.4.2.1. Liposomes
3.4.2.2. Exosomes
3.4.2.3. Prodrugs
3.4.2.4. Nanoparticles and Microspheres
3.4.2.5. Novel Formulations and Conjugates
3.4.3. Chemical Delivery Systems
3.5. Blood-Brain Barrier (BBB)
3.5.1. Key Historical Milestones
3.5.2. Structure and Key Components
3.5.3. Key Functions
3.6. Strategies for Drug Delivery across the BBB
3.6.1. Increasing Permeability by Temporary Disruption of the BBB
3.6.2. Pharmacological Strategies to Facilitate Transport Across the BBB
3.7. Challenges Associated with BBB Penetration and CNS Drug Delivery
3.8. Prevalent Trends Related to Non-Invasive BBB Penetration Technologies
3.8.1. Emerging Focus Areas
3.8.2. Key Historical Trends
3.8.3. Geographical Activity
3.9. Concluding Remarks

4. MARKET LANDSCAPE: NON-INVASIVE BBB PENETRATION TECHNOLOGIES

4.1. Chapter Overview
4.2. Non-Invasive BBB Penetration Technologies: Overall Market Landscape
4.2.1. Analysis by Status of Development
4.2.2. Analysis by Underlying Principle
4.2.3. Analysis by Compatible Pharmacological Molecule(s)
4.2.4. Analysis by Target Receptor(s)
4.2.5. Analysis by Target Disease Indication(s)
4.2.6. Analysis by Patent Availability
4.2.7. Analysis by Licensing Activity
4.3. Non-Invasive BBB Penetration Technology Providers: Overall Market Landscape
4.3.1. Analysis by Year of Establishment
4.3.2. Analysis by Company Size
4.3.3. Analysis by Location of Headquarters

5. MARKET LANDSCAPE: BBB PENETRATING DRUGS
5.1. Chapter Overview
5.2. BBB Penetrating Drugs: Development Pipeline
5.2.1. Analysis by Phase of Development
5.2.2. Analysis by Type of Molecule
5.2.3. Analysis by Affiliated BBB Penetration Technology
5.2.4. Analysis by Route of Administration
5.2.5. Analysis by Target Disease Indication(s)
5.2.6. Analysis by Therapeutic Area(s)
5.3. BBB Penetrating Drugs: Additional Information
5.4. BBB Penetrating Drug Developers: Overall Market Landscape
5.4.1. Analysis by Year of Establishment
5.4.2. Analysis by Company Size
5.4.3. Analysis by Location of Headquarters
5.4.4. Leading Drug Developers: Analysis by Number of Drugs
5.4.5. Leading Drug Developers: 4D Bubble Analysis based on Pipeline Strength, Target Disease Indication and Company Size
5.4.6. Heptagon Representation: Analysis by Phase of Development and Key Disease Indications
5.4.7. Tree Map Representation: Analysis by Key Disease Indications and Size of the Company

6. COMPANY PROFILES
6.1. Chapter Overview
6.2. Leading Players based in North America
6.2.1. Angiochem
6.2.1.1. Company Overview
6.2.1.2. Technology Overview
6.2.1.3. Product Portfolio
6.2.1.4. Recent Developments and Future Outlook
6.2.2. ArmaGen
6.2.2.1. Company Overview
6.2.2.2. Technology Overview
6.2.2.3. Product Portfolio
6.2.2.4. Recent Developments and Future Outlook
6.2.3. Denali Therapeutics
6.2.3.1. Company Overview
6.2.3.2. Technology Overview
6.2.3.3. Product Portfolio
6.2.3.4. Recent Developments and Future Outlook
6.2.4. ICB International
6.2.4.1. Company Overview
6.2.4.2. Technology Overview
6.5.4.3. Product Portfolio
6.2.4.4. Recent Developments and Future Outlook
6.2.5. Lauren Sciences
6.2.5.1. Company Overview
6.2.5.2. Technology Overview
6.2.5.3. Product Portfolio
6.2.5.4. Recent Developments and Future Outlook
6.3. Leading Players based in Europe
6.3.1. BioArctic
6.3.1.1. Company Overview
6.3.1.2. Technology Overview
6.3.1.3. Product Portfolio
6.3.1.4. Recent Developments and Future Outlook
6.3.2. Cyclenium Pharma
6.3.2.1. Company Overview
6.3.2.2. Technology Overview
6.3.2.3. Product Portfolio
6.3.2.4. Recent Developments and Future Outlook
6.3.3. Iproteos
6.3.3.1. Company Overview
6.3.3.2. Technology Overview
6.3.3.3. Product Portfolio
6.3.3.4. Recent Developments and Future Outlook
6.3.4. Medesis Pharma
6.3.4.1. Company Overview
6.3.4.2. Technology Overview
6.3.4.3. Product Portfolio
6.3.4.4. Recent Developments and Future Outlook
6.3.5. Ossianix
6.3.5.1. Company Overview
6.3.5.2. Technology Overview
6.3.5.3. Product Portfolio
6.3.5.4. Recent Developments and Future Outlook
6.3.6. Vect-Horus
6.3.6.1. Company Overview
6.3.6.2. Technology Overview
6.3.6.3. Product Portfolio
6.3.6.4. Recent Developments and Future Outlook
6.4. Leading Players based in Asia-Pacific
6.4.1. JCR Pharmaceuticals
6.4.1.1. Company Overview
6.4.1.2. Technology Overview
6.4.1.3. Product Portfolio
6.4.1.4. Recent Developments and Future Outlook

7. TECHNOLOGY COMPETITIVENESS ANALYSIS
7.1. Chapter Overview
7.2. Methodology and Key Parameters
7.3. BBB Penetration Technologies: Platform Competitiveness Analysis

8. NON-INVASIVE BBB PENETRATION TECHNOLOGIES: POPULAR APPROACHES
8.1. Chapter overview
8.2. Receptor Mediated Transcytosis (RMT)
8.2.1. Type of Target Receptors
8.2.1.1. Diphtheria Toxin Receptor
8.2.1.2. Insulin Receptor and Insulin-like Growth Factor Receptor
8.2.1.3. Low Density Lipoprotein Receptor-Related Proteins (LRP-1 and LRP-2)
8.2.1.4. Transferrin Receptor
8.2.2. Types of RMT Approaches
8.2.2.1. Bispecific Antibody-based Approach
8.2.2.2. Molecular Trojan Horse-based Approach
8.2.2.2.1. Important Considerations for Designing Molecular Trojan Horses
8.2.2.2.2. Considerations for Designing a Trojan Horse Liposome (THL)
8.2.2.2.3. Popular Conjugation Strategies
8.2.2.2.3.1. Direct Coupling Approach
8.2.2.2.3.2. Nanoparticles-based Approach
8.3. Increasing the Permeability of the BBB
8.3.1. Use of Ultrasound Waves
8.3.2. Use of High-Frequency Electric Field
8.4. Passive Diffusion
8.5. Novel Approaches
8.5.1. Cell Penetrating Peptides
8.5.2. Macrocycles
8.5.3. Organ-on-a-Chip Technology

9. PARTNERSHIPS AND COLLABORATIONS
9.1. Chapter Overview
9.2. Partnership Models
9.3. Non-Invasive BBB Technologies and Drugs: List of Partnerships and Collaborations
9.3.1. Analysis by Year of Partnership
9.3.2. Analysis by Type of Partnership
9.3.3. Analysis by Year and Type of Partnership
9.3.4. Analysis by Type of Partner
9.3.5. Analysis by Focus Area
9.3.6. Analysis by Type of Molecule
9.3.7. Analysis by Target Disease Indication
9.3.8. Most Active Players: Analysis by Number of Partnerships
9.3.9. Most Popular Technologies: Analysis by Number of Partnerships
9.3.10. Regional Analysis
9.3.11. Intercontinental and Intracontinental Agreements

10. ANALYSIS OF RECENT LICENSING AGREEMENTS
10.1. Chapter Overview
10.2. Licensing Agreements: Definition and Importance in Pharmaceutical Industry
10.3. Types of Licensing Agreements
10.3.1. Out-Licensing Agreements
10.3.2. In-Licensing Agreements
10.4. Components of Licensing Agreements
10.5. Recent Examples of BBB-Related Technology Licensing Agreements
10.5.1. Analysis by Year of Agreement
10.5.2. Analysis by Type of Licensing Agreement
10.5.3. Analysis by Type of Owner
10.5.4. Most Active Players: Analysis by Number of Licensing Agreements
10.5.5. Most Popular Technologies: Analysis by Number of Licensing Agreements
10.5.6. Regional Analysis
10.5.7. Intercontinental and Intracontinental Licensing Agreements
10.6. Case-in-Point: Technology Licensing Timeline
10.6.1. Sumitomo Dainippon Pharma and JCR Pharmaceuticals
10.6.2. Denali Therapeutics and Sanofi
10.6.3. biOasis Technologies and Prothena
10.6.4. Vect-Horus and Janssen Pharmaceuticals
10.7. Concluding Remarks

11. FUNDING AND INVESTMENT ANALYSIS
11.1. Chapter Overview
11.2. Types of Funding
11.3. Non-Invasive BBB Penetration Technologies and Drugs: List of Funding and Investments
11.3.1. Analysis by Number of Instances
11.3.2. Analysis by Amount Invested
11.3.3. Analysis by Type of Funding
11.3.4. Analysis by Type of Company
11.3.5. Analysis by Purpose of Funding
11.3.6. Analysis by Type of Molecule
11.3.7. Analysis by Target Disease Indication
11.3.8. Analysis by Geography
11.3.9. Most Active Players: Analysis by Number of Funding Instances
11.3.10. Most Popular Technologies: Analysis by Number of Funding Instances
11.3.11. Most Active Investors: Analysis by Number of Funding Instances
11.4. Concluding Remarks

12. PATENT ANALYSIS
12.1. Chapter Overview
12.2. Scope and Methodology
12.3. Non-Invasive BBB Penetration Technologies: Patent Analysis
12.3.1. Analysis by Application Year
12.3.1.1. Analysis by Filed Patent Applications
12.3.1.2. Analysis by Granted Patent Applications
12.3.2. Analysis by Issuing Authority / Patent Offices Involved
12.3.3. Analysis by CPC Symbols
12.3.4. Emerging Focus Areas
12.3.5. Analysis by Type of Organization
12.3.6. Leading Assignees: Analysis by Number of Patents
12.4. Non-Invasive BBB Technologies: Patent Valuation Analysis

13. DRUG DEVELOPMENT STRATEGY ANALYSIS
13.1. Chapter Overview
13.2 Scope and Methodology
13.3. Strategies Adopted by Late-Stage Drug Candidates
13.3.1. Drug A
13.3.2. Drug B
13.3.3. Drug C
13.3.4. Drug D
13.4. Concluding Remarks

14. MARKET POTENTIAL OF KEY NEUROLOGICAL DISORDERS
14.1. Chapter Overview
14.2. Market Potential of Key Neurological Disorders: 3D Bubble Chart Analysis
14.3. Key Neurological Disorders: Detailed Information
14.3.1. Alzheimer's Disease
14.3.1.1. Disease Description
14.3.1.2. Epidemiology
14.3.1.3. Symptoms
14.3.1.4. Current Treatment Options
14.3.1.5. BBB Penetrating Drugs for Alzheimer's Disease
14.3.1.6. Roots Analysis Perspective
14.3.2. Brain Cancer
14.3.2.1. Disease Description
14.3.2.2. Epidemiology
14.3.2.3. Symptoms
14.3.2.4. Current Treatment Options
14.3.2.4.1. Surgery
14.3.2.4.2. Radiation Therapy
14.3.2.4.3. Systemic Therapy
14.3.2.5. BBB Penetrating Drugs for Brain Cancer
14.3.2.6. Roots Analysis Perspective
14.3.3. Multiple Sclerosis
14.3.3.1. Disease Description
14.3.3.2. Epidemiology
14.3.3.3. Symptoms
14.3.3.4. Current Treatment Options
14.3.3.4.1. Treatment for Attacks
14.3.3.4.2. Treatments to Modify Progression
14.3.3.4.3. Interferons
14.3.3.5. BBB Penetrating Drugs for Multiple Sclerosis
14.3.3.6. Roots Analysis Perspective
14.3.4. Parkinson's Disease
14.3.4.1. Disease Description
14.3.4.2. Epidemiology
14.3.4.3. Symptoms
14.3.4.4. Current Treatment Options
14.3.4.4.1. Pharmacological Management of Parkinson's Disease
14.3.4.4.2. Non-Pharmacological Management of Parkinson's Disease
14.3.4.4.3. Management of Parkinson's Disease using Dietary Supplements
14.3.4.5. BBB Penetrating Drugs for Parkinson's Disease
14.3.4.6. Roots Analysis Perspective

15. LIKELY PARTNER ANALYSIS
15.1. Chapter Overview
15.2. Scope and Methodology
15.3. Potential Strategic Partners for Drug Development
15.3.1. Opportunities in North America
15.3.1.1. Most Likely Partners
15.3.1.2. Likely Partners
15.3.1.3. Less Likely Partners
15.3.2. Opportunities in Europe
15.3.2.1. Most Likely Partners
15.3.2.2. Likely Partners
15.3.2.3. Less Likely Partners
15.3.3. Opportunities in Asia-Pacific and Rest of the World
15.3.3.1. Most Likely Partners
15.3.3.2. Likely Partners
15.3.3.3. Less Likely Partners

16. MARKET FORECAST
16.1. Chapter Overview
16.2. Forecast Methodology and Key Assumptions
16.3. Overall BBB Penetration Technologies Market, 2020-2030
16.3.1. BBB Penetration Technologies Market: Contribution from Upfront Payments, 2020-2030
16.3.2. BBB Penetration Technologies Contribution from Milestone Payments, 2020-2030
16.4. Overall BBB Penetrating Drugs Market, 2020-2030
16.4.1. BBB Penetrating Drugs Market: Distribution by Type of Molecule
16.4.1.1. BBB Penetrating Drugs Market for Small Molecules, 2020-2030
16.4.1.2. BBB Penetrating Drugs Market for Biologics, 2020-2030
16.4.2. BBB Penetrating Drugs Market: Distribution by Target Disease Indication
16.4.2.1. BBB Penetrating Drugs Market for Brain Metastases in Breast Cancer, 2020-2030
16.4.2.2. BBB Penetrating Drugs Market for Glioblastoma Multiforme, 2020-2030
16.4.2.3. BBB Penetrating Drugs Market for Hunter Syndrome, 2020-2030
16.4.2.4. BBB Penetrating Drugs Market for Hurler Syndrome, 2020-2030
16.4.3. BBB Penetrating Drugs Market: Distribution by Key Geographical Regions
16.4.3.1. BBB Penetrating Drugs Market in North America, 2020-2030
16.4.3.2. BBB Penetrating Drugs Market in Europe, 2020-2030
16.4.3.3. BBB Penetrating Drugs Market in Asia-Pacific and Rest of the World, 2020-2030
16.4.4. BBB Penetrating Drugs Market: Distribution by Leading Technology Platforms
16.4.5. BBB Penetrating Drugs Market: Distribution by Leading Drug Developers
16.5.6. Drug-wise Sales Forecast
16.5.6.1. 2B3-101 / 2X-111 (2X Oncology)
16.5.6.1.1. Sales Forecast (USD Million)
16.5.6.1.2. Risk-Adjusted Market Opportunity (USD Million)
16.5.6.1.3. Net Present Value (USD Million)
16.5.6.1.4. Value Creation Analysis
16.5.6.2. AGT-181 (ArmaGen)
16.5.6.2.1. Sales Forecast (USD Million)
16.5.6.2.2. Risk-Adjusted Market Opportunity (USD Million)
16.5.6.2.3. Net Present Value (USD Million)
16.5.6.2.4. Value Creation Analysis
16.5.6.3. AGT-182 (ArmaGen)
16.5.6.3.1. Sales Forecast (USD Million)
16.5.6.3.2. Risk-Adjusted Market Opportunity (USD Million)
16.5.6.3.3. Net Present Value (USD Million)
16.5.6.3.4. Value Creation Analysis
16.5.6.4. ANG1005 (Angiochem)
16.5.6.4.1. Sales Forecast (USD Million)
16.5.6.4.2. Risk-Adjusted Market Opportunity (USD Million)
16.5.6.4.3. Net Present Value (USD Million)
16.5.6.4.4. Value Creation Analysis
16.5.6.5. JR-141 (JCR Pharmaceuticals)
16.5.6.5.1. Sales Forecast (USD Million)
16.5.6.5.2. Risk-Adjusted Market Opportunity (USD Million)
16.5.6.5.3. Net Present Value (USD Million)
16.5.6.5.4. Value Creation Analysis

17. CONCLUSION
17.1. Chapter Overview
17.2. Key Takeaways

18. EXECUTIVE INSIGHTS
18.1. Chapter Overview
18.2. Innovative California Biosciences International (ICBI)
18.2.1. Company Snapshot
18.2.2. Interview Transcript: Ram Bhatt, Chief Executive Officer, Chairman and Founder
18.3. Ossianix
18.3.1. Company Snapshot
18.3.2. Interview Transcript: Frank S Walsh, Chief Executive Officer and Founder
18.4. 2-BBB
18.4.1. Company Snapshot
18.4.2. Interview Transcript: Pieter Gaillard, Chief Executive Officer and Co-Founder
18.5. ArmaGen
18.5.1. Company Snapshot
18.5.2. Interview Transcript: Mathias Schmidt, Chief Executive Officer
18.6. biOasis Technologies
18.6.1. Company Snapshot
18.6.2. Interview Transcript: Rob Hutchison, Chief Executive Officer
18.7. Cyclenium Pharma
18.7.1. Company Snapshot
18.7.2. Interview Transcript: Mark L Peterson, Chief Operating Officer
18.8. Sagetis Biotech
18.8.1. Company Snapshot
18.8.2. Interview Transcript: Xavier Rivero, Chief Operating Officer
18.9. CarThera
18.9.1. Company Snapshot
18.9.2. Interview Transcript: Carole Desseaux, Head of Clinical Affairs
18.10. Vect-Horus
18.10.1. Company Snapshot
18.10.2. Interview Transcript: Jamal Temsamani, Head of Drug Development
18.11. Wyss Institute, Harvard University
18.11.1. Organization Snapshot
18.11.2. Interview Transcript: Kevin Kit Parker, Professor

19. APPENDIX I: TABULATED DATA

20. APPENDIX II: LIST OF COMPANIES AND ORGANIZATIONS

List of Figures
Figure 3.1 Structure of the Human Brain
Figure 3.2 Common Neurological Disorders
Figure 3.3 Important Statistics Related to Neurological Disorders
Figure 3.4 Strategies for Drug Delivery to the Central Nervous System (CNS)
Figure 3.5 Key Historical Milestones in BBB Research
Figure 3.6 Pathway Associated with the BBB
Figure 3.7 Transport Systems Associated with the BBB
Figure 3.8 Google Trends Analysis: Emerging Focus Areas
Figure 3.9 Google Trends Analysis: Historical Timeline
Figure 3.10 Google Trends Analysis: Geographical Activity
Figure 4.1 Non-Invasive BBB Penetration Technologies: Distribution by Status of Development
Figure 4.2 Non-Invasive BBB Penetration Technologies: Distribution by Underlying Principle
Figure 4.3 Non-Invasive BBB Penetration Technologies: Distribution by Compatible Pharmacological Molecule(s)
Figure 4.4 Non-Invasive BBB Penetration Technologies: Distribution by Target Receptor(s)
Figure 4.5 Non-Invasive BBB Penetration Technologies: Distribution by Target Disease Indication(s)
Figure 4.6 Non-Invasive BBB Penetration Technologies: Distribution by Patent Availability
Figure 4.7 Non-Invasive BBB Penetration Technologies: Distribution by Licensing Activity
Figure 4.8 Non-Invasive BBB Technology Providers: Distribution by Year of Establishment
Figure 4.9 Non-Invasive BBB Technology Providers: Distribution by Company Size
Figure 4.10 Non-Invasive BBB Technology Providers: Distribution by Location of Headquarters
Figure 5.1 BBB Penetrating Drugs: Distribution by Phase of Development
Figure 5.2 BBB Penetrating Drugs: Distribution by Type of Molecule
Figure 5.3 BBB Penetrating Drugs: Distribution by Affiliated BBB Penetration Technology
Figure 5.4 BBB Penetrating Drugs: Distribution by Route of Administration
Figure 5.5 BBB Penetrating Drugs: Distribution by Target Disease Indication(s)
Figure 5.6 BBB Penetrating Drugs: Distribution by Therapeutic Area(s)
Figure 5.7 BBB Penetrating Drug Developers: Distribution by Year of Establishment
Figure 5.8 BBB Penetrating Drug Developers: Distribution by Company Size
Figure 5.9 BBB Penetrating Drug Developers: Distribution by Location of Headquarters
Figure 5.10 Leading Drug Developers: Distribution by Number of Drugs
Figure 5.11 Leading Drug Developers: 4D Bubble Analysis based on Pipeline Strength, Target Disease Indication and Company Size
Figure 5.12 Heptagon Representation: Distribution by Phase of Development and Key Disease Indications
Figure 5.13 Tree Map Representation: Distribution by Key Disease Indications and Size of the Company
Figure 7.1 BBB Penetration Technologies: Platform Competitiveness Analysis
Figure 8.1 Receptor Mediated Transcytosis (RMT): Key Functions
Figure 8.2 RMT: Working Mechanism
Figure 8.3 Molecular Trojan Horse-based Approach: Working Mechanism
Figure 9.1 Partnerships and Collaborations: Cumulative Year-Wise Trend, Pre-2014-Q1 2020
Figure 9.2 Partnerships and Collaborations: Distribution by Type of Partnership
Figure 9.3 Partnerships and Collaborations: Year-Wise Trend by Type of Partnership
Figure 9.4 Partnerships and Collaborations: Distribution by Type of Partner
Figure 9.5 Partnerships and Collaborations: Year-Wise Trend by Type of Partner
Figure 9.6 Partnerships and Collaborations: Distribution by Type of Partner and Partnership Model
Figure 9.7 Partnerships and Collaborations: Distribution by Focus Area
Figure 9.8 Partnerships and Collaborations: Distribution by Type of Molecule
Figure 9.9 Partnerships and Collaborations: Year-Wise Trend by Type of Molecule
Figure 9.10 Partnerships and Collaborations: Distribution by Target Disease Indication
Figure 9.11 Partnerships and Collaborations: Year-Wise Trend by Target Disease Indication
Figure 9.12 Partnerships and Collaborations: Distribution by Target Disease Indication and Partnership Model
Figure 9.13 Most Active Players: Distribution by Number of Partnerships
Figure 9.14 Most Popular Technologies: Distribution by Number of Partnerships
Figure 9.15 Partnerships and Collaborations: Regional Distribution
Figure 9.16 Partnerships and Collaborations: Intercontinental and Intracontinental Agreements
Figure 10.1 Key Risks and Benefits Associated with a Licensee
Figure 10.2 Key Risks and Benefits Associated with a Licensor
Figure 10.3 Licensing Agreements: Distribution of Financial Components
Figure 10.4 BBB-Related Technology Licensing Agreements: Cumulative Year-Wise Trend, Pre-2014-Q1 2020
Figure 10.5 BBB-Related Technology Licensing Agreements: Distribution by Type of Licensing Agreement
Figure 10.6 BBB-Related Technology Licensing Agreements: Distribution by Type of Owner
Figure 10.7 Most Active Players: Distribution by Number of Licensing Agreements
Figure 10.8 BBB-Related Technology Licensing Agreements: Regional Analysis
Figure 10.9 BBB-Related Technology Licensing Agreements: Intercontinental and Intracontinental Agreements
Figure 10.10 BBB-Related Technology Licensing Agreements: Technology Providers' Perspective
Figure 11.1 Funding and Investment Analysis: Distribution of Companies by Year of Establishment and Type of Funding, Pre-2014-Q1 2020
Figure 11.2 Funding and Investment Analysis: Cumulative Number of Instances by Year, Pre-2014-Q1 2020
Figure 11.3 Funding and Investment Analysis: Distribution by Type of Funding and Year of Investment, Pre-2014-Q1 2020
Figure 11.4 Funding and Investment Analysis: Cumulative Amount Invested, Pre-2014-Q1 2020 (USD Million)
Figure 11.5 Funding and Investment Analysis: Year-Wise Distribution by Amount Invested and Type of Funding, Pre-2014-Q1 2020 (USD Million)
Figure 11.6 Funding and Investment Analysis: Distribution of Instances by Type of Funding, Pre-2014-Q1 2020
Figure 11.7 Funding and Investment Analysis: Distribution of Amount Invested by Type of Funding, Pre-2014-Q1 2020 (USD Million)
Figure 11.8 Funding and Investment Analysis: Summary of Amount Invested, Pre-2014-Q1 2020 (USD Million)
Figure 11.9 Funding and Investment Analysis: Distribution by Total Amount Invested and Type of Company, Pre-2014-Q1 2020 (USD Million)
Figure 11.10 Funding and Investment Analysis: Distribution of the Total Amount Invested by Purpose of Funding, Pre-2014-Q1 2020 (USD Million)
Figure 11.11 Funding and Investment Analysis: Distribution of Instances by Type of Molecule, Pre-2014-Q1 2020
Figure 11.12 Funding and Investment Analysis: Distribution of the Total Amount Invested by Type of Molecule, Pre-2014-Q1 2020 (USD Million)
Figure 11.13 Funding and Investment Analysis: Distribution by Target Disease Indication
Figure 11.14 Funding and Investment Analysis: Distribution of the Total Amount Invested by Target Disease Indication, Pre-2014-Q1 2020 (USD Million)
Figure 11.15 Funding and Investment Analysis: Distribution by Geography
Figure 11.16 Funding and Investment Analysis: Regional Distribution by Total Amount Invested, Pre-2014-Q1 2020
Figure 11.17 Most Active Players: Distribution by Number of Funding Instances and Amount Raised (USD Million)
Figure 11.18 Most Active Technologies: Distribution by Number of Funding Instances and Amount Raised (USD Million)
Figure 11.19 Most Active Investors: Distribution by Number of Funding Instances
Figure 11.20 Funding and Investment Summary, Pre-2014-Q1 2020 (USD Million)
Figure 12.1 Patent Portfolio: Distribution by Type of Patent
Figure 12.2 Patent Portfolio: Cumulative Distribution by Application Year, 2011-2019
Figure 12.3 Patent Portfolio: Distribution of Filed Patents by Application Year, 2011-2019
Figure 12.4 Patent Portfolio: Distribution of Granted Patents by Application Year, 2011-2019
Figure 12.5 Patent Portfolio: Distribution by Issuing Authority / Patent Offices Involved
Figure 12.6 Patent Portfolio: Distribution by CPC Symbols
Figure 12.7 Patent Portfolio: Emerging Focus Areas
Figure 12.8 Patent Portfolio: Cumulative Distribution by Type of Organization
Figure 12.9 Leading Patent Assignees: Distribution by Number of Patents
Figure 12.10 Patent Portfolio: Leading Non-Industry Players in Terms of Number of Patents
Figure 12.11 Patent Portfolio: Distribution by Patent Age (2000-2019)
Figure 12.12 Patent Portfolio: Distribution based on Proprietary Scoring Criteria
Figure 12.13 Patent Portfolio: Valuation Analysis
Figure 13.1 Commercial Development Strategies Adopted for Drug A
Figure 13.2 Commercial Development Strategies Adopted for Drug B
Figure 13.3 Commercial Development Strategies Adopted for Drug C
Figure 13.4 Commercial Development Strategies Adopted for Drug D
Figure 13.5 BBB Penetrating Drug Developers: Popular Development Strategies
Figure 14.1 Market Potential of Key Neurological Disorders: 3D Bubble Analysis based on Number of Approved Drugs, Pipeline Strength and Target Patient Population
Figure 14.2 Normal Brain versus Diseased Brain
Figure 14.3 Alzheimer's Disease: Phases of Disease Progression
Figure 14.4 Global Dementia-Related Statistics: 2015 and 2030 (Millions)
Figure 14.5 Alzheimer's Disease: Signs and Symptoms
Figure 14.6 Alzheimer's Disease: Dietary Supplements
Figure 14.7 Market Potential of Alzheimer's Disease: 3D Bubble Analysis based on Number of Approved Drugs, Pipeline Strength and Target Patient Population
Figure 14.8 Brain Cancer: Signs and Symptoms
Figure 14.9 Market Potential of Brain Cancer: 3D Bubble Analysis based on Number of Approved Drugs, Pipeline Strength and Target Patient Population
Figure 14.10 Multiple Sclerosis: Signs and Symptoms
Figure 14.11 Market Potential of Multiple Sclerosis: 3D Bubble Analysis based on Number of Approved Drugs, Pipeline Strength and Target Patient Population
Figure 14.12 Parkinson's Disease: Causal Environmental Factors
Figure 14.13 Parkinson's Disease: Gender-wise Incidence Rates
Figure 14.14 Parkinson's Disease: Disease Stages
Figure 14.15 Parkinson's Disease: Motor Symptoms
Figure 14.16 Parkinson's Disease: Secondary Symptoms
Figure 14.17 Parkinson's Disease Management: Non-Pharmacological Treatment Options
Figure 14.18 Parkinson's Disease Management: Surgical Methods
Figure 14.19 Parkinson's Disease Management: Dietary Supplements
Figure 14.20 Market Potential of Parkinson's Disease: 3D Bubble Analysis based on Number of Approved Drugs, Pipeline Strength and Target Patient Population
Figure 16.1 Technology Licensing: Distribution of Financial Components
Figure 16.2 Technology Licensing: Likely Market Evolution
Figure 16.3 BBB Penetration Technologies: Average Volume and Value of Upfront Payments (Units, USD Million)
Figure 16.4 BBB Penetration Technologies: Average Volume and Value of Milestone Payments (Units, USD Million)
Figure 16.5 Overall BBB Penetration Technologies Market, 2020-2030 (USD Million)
Figure 16.6 Overall BBB Penetrating Drugs Market, 2020-2030 (USD Million)
Figure 16.7 BBB Penetrating Drugs Market: Distribution by Type of Molecule, 2020 and 2030
Figure 16.8 BBB Penetrating Drugs Market for Small Molecules, 2020-2030 (USD Million)
Figure 16.9 BBB Penetrating Drugs Market for Biologics, 2020-2030 (USD Million)
Figure 16.10 BBB Penetrating Drugs Market: Distribution by Target Disease Indication, 2020 and 2030
Figure 16.11 BBB Penetrating Drugs Market for Brain Metastases in Breast Cancer, 2020-2030 (USD Million)
Figure 16.12 BBB Penetrating Drugs Market for Glioblastoma Multiforme, 2020-2030 (USD Million)
Figure 16.13 BBB Penetrating Drugs Market for Hunter Syndrome, 2020-2030 (USD Million)
Figure 16.14 BBB Penetrating Drugs Market for Hurler Syndrome, 2020-2030 (USD Million)
Figure 16.15 BBB Penetrating Drugs Market: Distribution by Key Geographical Regions, 2020 and 2030
Figure 16.16 BBB Penetrating Drugs Market in North America, 2020-2030 (USD Million)
Figure 16.17 BBB Penetrating Drugs Market in Europe, 2020-2030 (USD Million)
Figure 16.18 BBB Penetrating Drugs Market in Asia-Pacific and Rest of the World, 2020-2030 (USD Million)
Figure 16.19 BBB Penetrating Drugs Market: Distribution by Leading Technology Platforms, 2020 and 2030
Figure 16.20 BBB Penetrating Drugs Market: Distribution by Leading Drug Developers, 2020 and 2030
Figure 16.21 2B3-101 / 2X-111 (2X Oncology): Sales Forecast, till 2030 (USD Million)
Figure 16.22 2B3-101 / 2X-111 (2X Oncology): Risk-Adjusted Market Opportunity, till 2030 (USD Million)
Figure 16.23 AGT-181 (ArmaGen): Sales Forecast, till 2030 (USD Million)
Figure 16.24 AGT-181 (ArmaGen): Risk-Adjusted Market Opportunity, till 2030 (USD Million)
Figure 16.25 AGT-182 (ArmaGen): Sales Forecast, till 2030 (USD Million)
Figure 16.26 AGT-182 (ArmaGen): Risk-Adjusted Market Opportunity, till 2030 (USD Million)
Figure 16.27 ANG1005 (Angiochem): Sales Forecast, till 2030 (USD Million)
Figure 16.28 ANG1005 (Angiochem): Risk-Adjusted Market Opportunity, till 2030 (USD Million)
Figure 16.29 JR-141 (JCR Pharmaceuticals): Sales Forecast, till 2030 (USD Million)
Figure 16.30 JR-141 (JCR Pharmaceuticals): Risk-Adjusted Market Opportunity, till 2030 (USD Million)

List of Tables
Table 3.1 Key Components of the Human Brain
Table 3.2 Commercially Available Devices for CNS Drug Delivery
Table 3.3 Key Differences: Non-Invasive and Invasive BBB Technologies
Table 3.4 List of Key Constituents of the BBB
Table 3.5 Key Functions of the BBB
Table 3.6 List of Blood to Brain Transporters
Table 4.1 Non-Invasive BBB Penetration Technologies: List of Technology Platforms
Table 4.2 Non-Invasive BBB Penetration Technologies: List of Technology Providers
Table 5.1 BBB Penetrating Drugs: Development Pipeline
Table 5.2 BBB Penetrating Drugs: Additional Information
Table 5.3 BBB Penetrating Drugs: List of Drug Developers
Table 6.1 Non-Invasive BBB Penetration Technologies and Drugs: List of Companies Profiled
Table 6.2 Angiochem: Company Overview
Table 6.3 Angiochem: Product Portfolio
Table 6.4 Angiochem: Recent Developments and Future Outlook
Table 6.5 ArmaGen: Company Overview
Table 6.6 ArmaGen: Product Portfolio
Table 6.7 ArmaGen: Recent Developments and Future Outlook
Table 6.8 Denali Therapeutics: Company Overview
Table 6.9 Denali Therapeutics: Product Portfolio
Table 6.10 Denali Therapeutics: Recent Developments and Future Outlook
Table 6.11 ICB International: Company Overview
Table 6.12 ICB International: Product Portfolio
Table 6.13 ICB International: Recent Developments and Future Outlook
Table 6.14 Lauren Sciences: Company Overview
Table 6.15 Lauren Sciences: Product Portfolio
Table 6.16 Lauren Sciences: Recent Developments and Future Outlook
Table 6.17 BioArctic: Company Overview
Table 6.18 BioArctic: Product Portfolio
Table 6.19 BioArctic: Recent Developments and Future Outlook
Table 6.20 Cyclenium Pharma: Company Overview
Table 6.21 Cyclenium Pharma: Product Portfolio
Table 6.22 Cyclenium Pharma: Recent Developments and Future Outlook
Table 6.23 Iproteos: Company Overview
Table 6.24 Iproteos: Product Portfolio
Table 6.25 Iproteos: Recent Developments and Future Outlook
Table 6.26 Medesis Pharma: Company Overview
Table 6.27 Medesis Pharma: Product Portfolio
Table 6.28 Medesis Pharma: Recent Developments and Future Outlook
Table 6.29 Ossianix: Company Overview
Table 6.30 Ossianix: Product Portfolio
Table 6.31 Ossianix: Recent Developments and Future Outlook
Table 6.32 Vect-Horus: Company Overview
Table 6.33 Vect-Horus: Product Portfolio
Table 6.34 Vect-Horus: Recent Developments and Future Outlook
Table 6.35 JCR Pharmaceuticals: Company Overview
Table 6.36 JCR Pharmaceuticals: Product Portfolio
Table 6.37 JCR Pharmaceuticals: Recent Developments and Future Outlook
Table 9.1 Non-Invasive BBB Penetration Technologies and Drugs: Partnerships and Collaborations, Information on Partnership Type, Year and Type of Partner, till Q1 2020
Table 9.2 Non-Invasive BBB Penetration Technologies and Drugs: Partnerships and Collaborations, Information on Type of Molecule, Target Indication and Focus Area, till Q1 2020
Table 10.1 List of BBB-Related Technology Licensing Agreements, till Q1 2020
Table 10.2 Licensing Agreement Details: Sumitomo Dainippon Pharma and JCR Pharmaceuticals
Table 10.3 Licensing Agreement Details: Denali Therapeutics and Sanofi
Table 10.4 Licensing Agreement Details: biOasis Technologies and Prothena
Table 10.5 Licensing Agreement Details: Vect-Horus and Janssen Pharmaceuticals
Table 11.1 Non-Invasive BBB Penetration Technologies and Drugs: Funding and Investments, Information on Funding Type, Year, Amount and Investor, till Q1 2020
Table 11.2 Non-Invasive BBB Penetration Technologies and Drugs: Funding and Investments, Information on Type of Molecule, Target Indication and Focus Area, till Q1 2020
Table 12.1 Patent Portfolio: Definitions of CPC Symbols
Table 12.2 Patent Portfolio: Most Popular CPC Symbols
Table 14.1 Alzheimer's Disease: List of Marketed Drugs
Table 14.2 Alzheimer's Disease: List of BBB Penetrating Drugs
Table 14.3 Brain Cancer: List of Marketed Drugs
Table 14.4 Brain Cancer: List of BBB Penetrating Drugs
Table 14.5 Multiple Sclerosis: List of Marketed Drugs
Table 14.6 Multiple Sclerosis: List of BBB Penetrating Drugs
Table 14.7 Parkinson's Disease: List of Marketed Drugs
Table 14.8 Parkinson's Disease: List of BBB Penetrating Drugs
Table 15.1 Opportunities in North America: Most Likely Partners
Table 15.2 Opportunities in North America: Likely Partners

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