1. Introduction to CFTR Modulators
1.1 Overview
1.2 Evolution of CFTR Modulators
1.3 CFTR Modulators Mechanism of Action

2. Global CFTR Modulator Market Overview
2.1 Current Market Scenario
2.2 Future Market Potential of CFTR Modulators

3. US CFTR Modulator Market Overview
3.1 Current Market Scenario
3.2 Future Market Potential of CFTR Modulators

4. ROW CFTR Modulator Market Overview
4.1 Current Market Scenario
4.2 Future Market Potential of CFTR Modulators

5. Ivacaftor (Kalydeco) - Clinical & Commercial Insight
5.1 Overview
5.2 Patents & Assignees
5.3 Price & Dosage Insight
5.4 Sales Analysis

6. Ivacaftor/Lumacaftor (Orkambi) - Clinical & Commercial Insight
6.1 Overview
6.2 Patents & Assignees
6.3 Price & Dosage Insight
6.4 Sales Analysis

7. Tezacaftor/Ivacaftor (Symdeko) - Clinical & Commercial Insight
7.1 Overview
7.2 Patent & Assignees
7.3 Price & Dosage Insight
7.4 Sales

8. Elexacaftor/Ivacaftor/Tezacaftor (Trikafta) - Clinical & Commercial Insight
8.1 Overview
8.2 Patent & Assignees
8.3 Price & Dosage Insight
8.4 Global Sales

9. Global CFTR Modulators Clinical Pipeline Overview
9.1 By Country
9.2 By Company
9.3 By Patient Segment
9.4 By Phase

10. Global CFTR Modulators Clinical Trials Insight
10.1 Research
10.2 Preclinical
10.3 Phase-I
10.4 Phase-I/II
10.5 Phase-II
10.6 Phase-III

11. Marketed CFTR Modulators Clinical Insights

12. CFTR Modulator Drugs Market Dynamics
12.1 Favorable Parameters
12.2 Market Restraints

13. CFTR Modulator Market Future Perspective

14. Competitive Landscape
14.1 Vertex Pharmaceuticals
14.2 Eloxx Pharma
14.3 ReCode Therapeutics
14.4 Arcturus Therapeutics
14.5 AbbVie
14.6 Spirovant Sciences
14.7 Translate Bio
14.8 ReAlta Life Sciences
14.9 Southern Research Institute
14.10 4D Molecular Therapeutics

List of Figures
Figure 1-1: Different Approaches for CFTR Modulators
Figure 1-2: Classes of CFTR Protein Mutations
Figure 1-3: History of CFTR Modulators
Figure 1-4: CFTR Modulators - Specific Target for Different Approaches

Figure 2-1: Global - CFTR Modulator Drugs Market Size (US$ Million), 2017-2021
Figure 2-2: Global - CFTR Modulator Drugs Market Size by Product (US$ Million),
2020 & 2021
Figure 2-3: Global - CFTR Modulator Drugs Market Size by Product (%), 2021
Figure 2-4: Global - CFTR Modulator Drugs Market Size by Product (%), 2020
Figure 2-5: Global - CFTR Modulator Drugs Market (US$ Billion), 2022-2028
Figure 2-6: Global - Cystic Fibrosis Incidence, 2020-2026

Figure 3-1: US - Incidence of Cystic Fibrosis, 2010-2020
Figure 3-2: Global - CFTR Modulator Market Size by Region (US$ Billion), 2021
Figure 3-3: Global - CFTR Modulator Market Size by Region (%), 2021
Figure 3-4: US - Expected CFTR Modulator Drugs Market Size (US$ Billion), 2022 -
2028
Figure 3-5: US - Cystic Fibrosis Incidence, 2021-2026

Figure 4-1: Global - CFTR Modulator Market Size by Region (US$ Billion), 2021
Figure 4-2: Global - CFTR Modulator Market Size by Region (%), 2021
Figure 4-3: ROW - Expected CFTR Modulator Drugs Market Size (US$ Billion), 2020 -
2028
Figure 4-4: ROW - Cystic Fibrosis Incidence, 2020-2026

Figure 5-1: US - Kalydeco FDA Approval History
Figure 5-2: Europe - Kalydeco FDA Approval History
Figure 5-3: US- Kalydeco FDA Approval & Patent Expiration Year
Figure 5-4: Europe - Kalydeco FDA Approval & Patent Expiration Year
Figure 5-5: US - Kalydeco Patent Approval & Expiration Year
Figure 5-6: US - Cost of Supply of 56 Oral Granule & Per Unit Cost of Kalydeco Oral
Granule (US$), May'2022
Figure 5-7: US - Cost of Supply of 56 Oral Tablet & Per Unit Cost of 150mg Kalydeco
Oral Tablet (US$), May'2022
Figure 5-8: Europe - Cost of Supply of 28 Oral Tablet & Per Unit Cost of 150mg
Kalydeco Oral Tablet (Eur/US$), May'2022
Figure 5-9: Europe - Cost of Supply of 56 Oral Tablet & Per Unit Cost of 50mg, 75mg
& 150mg Kalydeco Oral Tablet (Eur/US$), May'2022
Figure 5-10: UK - Cost of Supply of 56 Oral Granules & Per Unit Cost of 25mg, 50mg
& 75mg Kalydeco Oral Granules (GBP/US$), May'2022
Figure 5-11: UK - Cost of Supply of 56 Oral Tablet & Per Unit Cost of 150mg
Kalydeco Oral Tablet (GBP/US$), May'2022
Figure 5-12: UK - Cost of Supply of 28 Oral Tablet & Per Unit Cost of 150mg
Kalydeco Oral Tablet (GBP/US$), May'2022
Figure 5-13: Kalydeco - Recommended Pediatric Dose of Oral Granules for Cystic
Fibrosis by Weight (mg/12hrs)
Figure 5-14: Kalydeco - Maximum Recommended Pediatric Dose for Cystic Fibrosis
by Type (mg/12hrs)
Figure 5-15: Global - Kalydeco Sales (US$ Million), Q1'2021 & Q1'2022
Figure 5-16: Global - Kalydeco Annual Sales (US$ Million), 2017-2021
Figure 5-17: Global - Kalydeco Quarterly Sales (US$ Million), 2021
Figure 5-18: Global - Kalydeco Quarterly Sales (US$ Million), 2020
Figure 5-19: Global - Kalydeco Quarterly Sales (US$ Million), 2019

Figure 6-1: US - Orkambi FDA Approval History by Age
Figure 6-2: Europe - Orkambi FDA Approval History by Age
Figure 6-3: US- Orkambi FDA Approval & Patent Expiration Year
Figure 6-4: Europe - Orkambi FDA Approval & Patent Expiration Year
Figure 6-5: US - Orkambi Patent Approval & Expiration Year
Figure 6-6: US - Cost of Supply of 56 Oral Granule & Per Unit Cost of Orkambi Oral
Granule (US$), May'2022
Figure 6-7: US - Cost of Supply of 112 Oral Tablet & Per Unit Cost of Orkambi Oral
Tablet (US$), May'2022
Figure 6-8: Europe - Cost of Supply of 112 Oral Tablet & Per Unit Cost of Orkambi
Oral Tablet (Euro/US$), May'2022
Figure 6-9: UK- Cost of Supply of 112 Oral Tablet & Per Unit Cost of Orkambi Oral
Tablet (GBP/US$), May'2022
Figure 6-10: UK- Cost of Supply of 56 Oral Granules & Per Unit Cost of Orkambi Oral
Granule (GBP/US$), May'2022

Figure 6-11: Orkambi - Recommended Dose by Age (mg/day)
Figure 6-12: Global - Orkambi Sales (US$ Million), Q1'2021 & Q1'2022
Figure 6-13: Global - Orkambi Annual Sales (US$ Million), 2017-2021
Figure 6-14: Global - Orkambi Quarterly Sales (US$ Million), 2021
Figure 6-15: Global - Orkambi Quarterly Sales (US$ Million), 2020
Figure 6-16: Global - Orkambi Quarterly Sales (US$ Million), 2019

Figure 7-1: US - Symdeko FDA Approval History by Age
Figure 7-2: Europe - Symdevi EU Approval History by Age
Figure 7-3: Europe - Symdevi Approval & Patent Expiration Year
Figure 7-4: US - Symdeko Approval & Patent Expiration Year
Figure 7-5: US - Symdeko Patent Approval & Expiration Year
Figure 7-6: US - Cost of Supply of 56 Oral Tablet & Per Unit Cost of Symdeko Oral
Tablet (US$), May'2022
Figure 7-7: Europe - Cost of Supply of 56 Oral Tablet & Per Unit Cost of Symdeko
Oral Tablet (Euro/US$), May'2022
Figure 7-8: Europe - Cost of Supply of 28 Oral Tablet & Per Unit Cost of Symkevi
Oral Tablet (GBP/US$), May'2022
Figure 7-9: Global - Symdeko/Symkevi Sales (US$ Million), Q1'2021 & Q1'2022
Figure 7-10: Global - Symdeko/Symkevi Annual Sales (US$ Million), 2018-2021
Figure 7-11: Global - Symdeko/Symkevi Quarterly Sales (US$ Million), 2021
Figure 7-12: Global - Symdeko/Symkevi Quarterly Sales (US$ Million), 2020
Figure 7-13: Global - Symdeko/Symkevi Quarterly Sales (US$ Million), 2019

Figure 8-1: US - Trikafta FDA Approval History by Mutation
Figure 8-2: Trikafta/Kaftrio - Initial Approval Year by Region
Figure 8-3: Europe - Kaftrio Approval & Patent Expiration Year
Figure 8-4: US - Trikafta Approval & Patent Expiration Year
Figure 8-5: US - Trikafta Patent Approval & Expiration Year
Figure 8-6: US - Cost of Supply of 84 Oral Tablet & Per Unit Cost of Trikafta Oral
Tablet (US$), May'2022
Figure 8-7: Europe - Cost of Supply of 56 Oral Tablet & Per Unit Cost of Kaftrio Oral
Tablet (Euro/US$), May'2022
Figure 8-8: UK - Cost of Supply of 56 Oral Tablet & Per Unit Cost of Kaftrio Oral
Tablet (GBP/US$), May'2022
Figure 8-9: Trikafta/Kaftrio - Recommended Initial & Reduced Dose (mg/day)
Figure 8-10: Global - Trikafta/Kaftrio Sales (US$ Million), Q1'2021 & Q1'2022
Figure 8-11: Global - Trikafta/Kaftrio Annual Sales (US$ Million), 2019 - 2021
Figure 8-12: Global - Trikafta/Kaftrio Quarterly Sales (US$ Million), 2021
Figure 8-13: Global - Trikafta/Kaftrio Quarterly Sales (US$ Million), 2020

Figure 9-1: Global - CFTR Modulators in Clinical Pipeline by Country, 2022 till 2028
Figure 9-2: Global - CFTR Modulators in Clinical Pipeline by Company, 2022 till 2028
Figure 9-3: Global - CFTR Modulators in Clinical Pipeline by Patient Segment, 2022
till 2028
Figure 9-4: Global - CFTR Modulators in Clinical Pipeline by Phase, 2022 till 2028
Figure 12-1: CFTR Modulator Market Favorable Parameters
Figure 12-2: Global - CFTR Modulator Annual Sales by Product (US$ Million), 2020
Figure 12-3: US - CFTR Modulator Annual WAC by Product (US$)
Figure 12-4: Stages of Drug Development

Companies Mentioned
. Vertex Pharmaceuticals
. Eloxx Pharma
. ReCode Therapeutics
. Arcturus Therapeutics
. AbbVie
. Spirovant Sciences
. Translate Bio
. ReAlta Life Sciences
. Southern Research Institute
. 4D Molecular Therapeutics
.