The number of prevalent tuberculosis cases in the US is projected to decrease from 5.74 thousand in 2024 to 3.3 thousand by 2028. This represents a year-on-year decrease of approximately 11% from 2024 to 2025, around 12% from 2025 to 2026, about 13.5% from 2026 to 2027, and roughly 15% from 2027 to 2028. The compound annual growth rate (CAGR) over this five-year period is expected to be approximately -13.5%, illustrating a steady decline in tuberculosis prevalence.

Future trends to watch for include:

Innovations in TB diagnostics and treatments that could further reduce case numbers.
Potential changes in immigration and public health policy that may impact TB exposure and management.
Continued public health campaigns and vaccination efforts to prevent the spread of TB.
Effects of social determinants of health, such as housing and healthcare access, on TB prevalence.